ENSDARG00000022712


Danio rerio

Features
Gene ID: ENSDARG00000022712
  
Biological name :stat3
  
Synonyms : signal transducer and activator of transcription 3 (acute-phase response factor) / stat3
  
Possible biological names infered from orthology : P40763 / P42227 / signal transducer and activator of transcription 3
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 17030665
Gene end: 17107445
  
Corresponding Affymetrix probe sets: Dr.8150.2.S1_a_at (Zebrafish Array)   NM_131479_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000075300
Ensembl peptide - ENSDARP00000144241
Ensembl peptide - ENSDARP00000134796
Ensembl peptide - ENSDARP00000095292
NCBI entrez gene - 30767     See in Manteia.
RefSeq - NM_131479
RefSeq - XM_005163794
RefSeq - XM_005163795
RefSeq - XM_005163796
RefSeq - XM_021469347
RefSeq Peptide - NP_571554
swissprot - O93599
swissprot - Q6NV46
swissprot - A0A286YAL2
swissprot - A0A1S6L757
swissprot - A0A1S6L752
swissprot - A0A0R4IGF2
ZFIN ID - ZDB-GENE-980526-68
Ensembl - ENSDARG00000022712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STAT3ENSGALG00000003267Gallus gallus
 STAT3ENSG00000168610Homo sapiens
 Stat3ENSMUSG00000004040Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
stat4 / signal transducer and activator of transcription 4 / Q14765*ENSDARG0000002873144
stat1a / signal transducer and activator of transcription 1a / STAT1* / P42224* / signal transducer and activator of transcription 1*ENSDARG0000000626644
stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*ENSDARG0000007618243
stat2 / signal transducer and activator of transcription 2 / P52630*ENSDARG0000003164741
stat5a / signal transducer and activator of transcription 5a / P42232* / P51692* / STAT5B* / P42229* / P42230* / signal transducer and activator of transcription 5B*ENSDARG0000001939228
stat5b / signal transducer and activator of transcription 5b / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*ENSDARG0000005558828
stat6 / signal transducer and activator of transcription 6, interleukin-4 induced / P42226* / P52633* / Signal transducer and transcription activator 6 * / signal transducer and activator o...ENSDARG0000001590223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0003401 axis elongation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007259 JAK-STAT cascade IMP
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0008361 regulation of cell size IMP
 biological_processGO:0030010 establishment of cell polarity IMP
 biological_processGO:0031099 regeneration IGI
 biological_processGO:0035677 posterior lateral line neuromast hair cell development IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0060119 inner ear receptor cell development IMP
 biological_processGO:0060252 positive regulation of glial cell proliferation IMP
 biological_processGO:0061026 cardiac muscle tissue regeneration IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
Signaling by SCF-KIT
Downstream signal transduction
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood macrophage increased amount , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
anatomical structure increased amount , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer Muller cell decreased amount , abnormal
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 ZFA:0000051 otic vesicle otic vesicle has fewer parts of type otolith , abnormal
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 ZFA:0000072 somite 1 somite 1 lateral region has fewer parts of type notochord cell, abnormal
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 ZFA:0000075 spinal cord spinal cord bent , abnormal
Show

 ZFA:0000093 blastomere blastomere decreased amount , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye apoptotic , abnormal
eye fused with eye , abnormal
eye adjacent to eye , abnormal
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 ZFA:0000135 notochord notochord decreased length , abnormal
notochord cell shape , abnormal
notochord cell decreased length , abnormal
notochord cell increased width , abnormal
notochord cell increased area , abnormal
notochord decreased length , exacerbated
Show

 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer retinal cone cell decreased amount , abnormal
Show

 ZFA:0000155 somite somite anterior-posterior axis decreased length , abnormal
somite adaxial cell decreased amount , abnormal
somite anterior-posterior axis decreased length , exacerbated
somite adaxial cell decreased amount , exacerbated
Show

 ZFA:0000168 anterior macula anterior macula has fewer parts of type hair cell anterior macula , abnormal
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 ZFA:0000243 neuromast neuromast has fewer parts of type hair cell , abnormal
neuromast decreased amount , abnormal
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 ZFA:0000728 somite 2 somite 2 lateral region has fewer parts of type notochord cell, abnormal
Show

 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism cell decreased distribution , abnormal
whole organism cell decreased amount , abnormal
whole organism decreased amount , abnormal
whole organism decreased life span , abnormal
Show

 ZFA:0001114 head head decreased amount , abnormal
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 ZFA:0005621 bone tissue bone tissue decreased volume , abnormal
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 ZFA:0009141 macrophage macrophage amount , ameliorated
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 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell apoptotic , abnormal
Show

 ZFA:0009280 Muller cell Muller cell proliferative , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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