MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
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MP:0000221 | decreased WBC count | "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0000222 | decreased neutrophil count | "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0000223 | decreased monocyte count | "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0000336 | decreased mast cell number | "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tbx21tm1Srnr/Tbx21+ Genetic Background: involves: C57BL/6
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MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer Genetic Background: involves: 129S6/SvEvTac
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MP:0000359 | abnormal mast cell morphology | "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tbx21tm1Srnr/Tbx21+ Genetic Background: involves: C57BL/6
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MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
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MP:0000628 | abnormal mammary gland development | "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Uoxin/Uoxin Genetic Background: involves: C57BL/6J * DBA/2J
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MP:0000662 | abnormal branching of the mammary ductal tree | "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Stat5atm1Jni/Stat5atm1Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
Allelic Composition: Stat5atm1Mam/Stat5atm1Mam Genetic Background: either: 129S6/SvEvTac-Stat5atm1Mam or (involves: 129S6/SvEvTac * NIH Black Swiss)
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MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr Genetic Background: C57BL/6J-Adam17m1Btlr
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MP:0001168 | prostate epithelial dysplasia | "abnormal development of the prostate epithelium" [J:63764] |
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Allelic Composition: Tbx21tm1Srnr/Tbx21+ Genetic Background: involves: C57BL/6
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MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0 Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N
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MP:0001261 | obese | "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Leprm5Btlr/Leprm5Btlr Genetic Background: C57BL/6-Leprm5Btlr
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0 Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N
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MP:0001433 | polyphagia | "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Adgra2tm1Cjku/Adgra2tm2Cjku,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129/Sv * C3H * C57BL/6
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MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer Genetic Background: involves: 129S6/SvEvTac
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MP:0001601 | abnormal myelopoiesis | "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
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MP:0001881 | abnormal mammary gland physiology | "aberrant function of of the milk-secreting gland that lies within the breast" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Adamts5tm1.1Eam/Adamts5+ Genetic Background: involves: 129S5/SvEvBrd
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MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
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MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+ Genetic Background: involves: BALB/c * C57BL/6
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0002401 | abnormal lymphopoiesis | "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tg(Mnx1-Zfp106,-EGFP)2Blk/0,Zfp106tm1b(KOMP)Wtsi/Zfp106tm1b(KOMP)Wtsi Genetic Background: involves: C57BL/6N
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MP:0002415 | abnormal neutrophil morphology/development | "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0002416 | abnormal proerythroblast morphology/development | "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0002423 | abnormal mast cell physiology | "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+ Genetic Background: involves: BALB/c * C57BL/6
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MP:0002463 | abnormal neutrophil physiology | "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0002498 | abnormal acute inflammation | "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr Genetic Background: C57BL/6J-Adam17m1Btlr
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MP:0002640 | reticulocytosis | "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0002642 | anisocytosis | "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0002643 | poikilocytosis | "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0002680 | decreased number of corpora lutea | "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
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MP:0002813 | microcytosis | "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0003059 | decreased insulin secretion | "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
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MP:0003607 | abnormal prostate physiology | "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tbx21tm1Srnr/Tbx21+ Genetic Background: involves: C57BL/6
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MP:0003838 | abnormal milk ejection | "impaired milk ejection reflex in response to suckling during lactation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36926] |
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0003944 | abnormal T cell subpopulation ratio | "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator] |
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr Genetic Background: C57BL/6J-Adam17m1Btlr
Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0003960 | increased lean body mass | "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0003961 | decreased lean body mass | "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0 Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N
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MP:0004701 | decreased circulating insulin-like growth factor I level | "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0 Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N
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MP:0004946 | abnormal regulatory T cell physiology | "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
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MP:0005070 | defective NK cell cytolysis | "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213] |
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Allelic Composition: Gbatm1.1Karl/Gba+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0005290 | decreased oxygen consumption | "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0005334 | abnormal fat pad | "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Adamts5tm1.1Eam/Adamts5+ Genetic Background: involves: 129S5/SvEvBrd
Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0005458 | increased percent body fat | "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0005460 | abnormal leukopoiesis | "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0005462 | abnormal mast cell morphology/development | "anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tbx21tm1Srnr/Tbx21+ Genetic Background: involves: C57BL/6
Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: involves: 129 * C57BL/6
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MP:0005559 | increased circulating glucose level | "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
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MP:0005562 | decreased mean corpuscular hemoglobin | "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0006269 | abnormal mammary gland growth during pregnancy | "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Stat5atm1Mam/Stat5atm1Mam Genetic Background: either: 129S6/SvEvTac-Stat5atm1Mam or (involves: 129S6/SvEvTac * NIH Black Swiss)
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MP:0006270 | abnormal mammary gland growth during lactation | "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Stat5atm1Mam/Stat5atm1Mam Genetic Background: either: 129S6/SvEvTac-Stat5atm1Mam or (involves: 129S6/SvEvTac * NIH Black Swiss)
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)1Mam/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0006413 | increased T cell apoptosis | "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0008045 | decreased NK cell number | "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"] |
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Allelic Composition: Gbatm1.1Karl/Gba+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0008076 | abnormal CD4-positive T cell differentiation | "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cishtm1.2Cdon/Cishtm1.2Cdon Genetic Background: B6.129S6(Cg)-Cishtm1.2Cdon
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MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR
Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0008246 | abnormal leukocyte morphology | "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637] |
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Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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MP:0008388 | hypochromic microcytic anemia | "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0008614 | increased circulating interleukin-17 level | "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008681 | increased interleukin-17 secretion | "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008807 | increased liver iron level | "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0008810 | increased circulating iron level | "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0008908 | increased total fat pad weight | "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0008973 | decreased erythroid progenitor cell number | "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0009254 | disorganized pancreatic islets | "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0009339 | decreased splenocyte number | "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gbatm1.1Karl/Gba+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0009506 | abnormal mammary gland alveolus morphology | "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)1Mam/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0009737 | prostate gland cysts | "benign epithelial growths, often fluid-filled, within the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tbx21tm1Srnr/Tbx21+ Genetic Background: involves: C57BL/6
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MP:0010024 | increased total body fat amount | "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0 Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0010067 | increased red blood cell distribution width | "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0010169 | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: involves: 129 * C57BL/6
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MP:0010172 | abnormal mammary gland epithelium physiology | "any functional anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0010249 | lactation failure | "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Stat5atm1Mam/Stat5atm1Mam Genetic Background: either: 129S6/SvEvTac-Stat5atm1Mam or (involves: 129S6/SvEvTac * NIH Black Swiss)
Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(MMTV-cre)1Mam/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0011049 | impaired adaptive thermogenesis | "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744] |
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Allelic Composition: Stat5atm2Mam/Stat5atm2Mam,Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL
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MP:0011696 | absent mast cells | "any structural anomaly of a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation; progenitors leave bone marrow and mature in connective and mucosal tissue; mature mast cells are found in all tissues, except the bloodstream." [CL:0000097] |
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Allelic Composition: Stat5atm1Jni/Stat5atm1Jni,Stat5btm2Jni/Stat5btm2Jni Genetic Background: involves: 129 * C57BL/6
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MP:0014126 | increased mammary gland apoptosis | "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna] |
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Allelic Composition: Cacna2d2tm1Svi/Cacna2d2tm1Svi Genetic Background: involves: 129S1/Sv * C57BL/6J
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