ENSMUSG00000026104


Mus musculus

Features
Gene ID: ENSMUSG00000026104
  
Biological name :Stat1
  
Synonyms : signal transducer and activator of transcription 1 / Stat1
  
Possible biological names infered from orthology : P42224
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.1
Gene start: 52119440
Gene end: 52161865
  
Corresponding Affymetrix probe sets: 10346191 (MoGene1.0st)   1420915_at (Mouse Genome 430 2.0 Array)   1440481_at (Mouse Genome 430 2.0 Array)   1450033_a_at (Mouse Genome 430 2.0 Array)   1450034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141125
Ensembl peptide - ENSMUSP00000140875
Ensembl peptide - ENSMUSP00000141132
Ensembl peptide - ENSMUSP00000141144
Ensembl peptide - ENSMUSP00000066743
Ensembl peptide - ENSMUSP00000139746
Ensembl peptide - ENSMUSP00000140482
Ensembl peptide - ENSMUSP00000140518
Ensembl peptide - ENSMUSP00000140643
NCBI entrez gene - 20846     See in Manteia.
MGI - MGI:103063
RefSeq - XM_017319464
RefSeq - NM_001205313
RefSeq - NM_001205314
RefSeq - NM_001357627
RefSeq - NM_009283
RefSeq - XM_006495811
RefSeq - XM_017319463
RefSeq Peptide - NP_001192242
RefSeq Peptide - NP_001192243
RefSeq Peptide - NP_001344556
RefSeq Peptide - NP_033309
swissprot - A0A087WSQ5
swissprot - A0A087WSP5
swissprot - Q8C3V4
swissprot - Q8CFQ1
swissprot - Q99K94
swissprot - A0A087WRI1
Ensembl - ENSMUSG00000026104
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat1aENSDARG00000006266Danio rerio
 stat1bENSDARG00000076182Danio rerio
 STAT1ENSGALG00000007651Gallus gallus
 STAT1ENSG00000115415Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*ENSMUSG0000000404053
Stat4 / signal transducer and activator of transcription 4 / Q14765*ENSMUSG0000006293952
Stat2 / signal transducer and activator of transcription 2 / P52630*ENSMUSG0000004003340
P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*ENSMUSG0000002091929
P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*ENSMUSG0000000404328
Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*ENSMUSG0000000214724


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR022752  Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
 IPR035859  STAT1, SH2 domain
 IPR036535  STAT transcription factor, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0010742 macrophage derived foam cell differentiation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0035456 response to interferon-beta IEA
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046725 negative regulation by virus of viral protein levels in host cell IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060337 type I interferon signaling pathway IEA
 biological_processGO:0061326 renal tubule development IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0000578 ulcerated paws "inflammatory, often suppurating lesions on the paws; often become necrotic" [J:17194]
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Allelic Composition: Ptpn6m1Btlr/Ptpn6m1Btlr,Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ptpn6m1Btlr Ticam1Lps2

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0001655 multifocal hepatic necrosis "multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Jak3wil/Jak3wil
Genetic Background: C57BL/6JSfdAnu-Jak3wil/Anu

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: involves: 129S/SvEv

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S1/Sv

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish
Genetic Background: B6.129P2-Socs1tm1Kish

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129S-Stat1tm1Dlv

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbxa2rtm1Cof/Tbxa2rtm1Cof
Genetic Background: involves: 129P2/OlaHsd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

Allelic Composition: Stat1m2Btlr/Stat1m2Btlr
Genetic Background: C57BL/6J-Stat1m2Btlr

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat2tm1Shnd/Stat2tm1Shnd
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1m1Btlr/Stat1m1Btlr
Genetic Background: C57BL/6J-Stat1m1Btlr

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3wil/Jak3wil
Genetic Background: C57BL/6JSfdAnu-Jak3wil/Anu

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0003062 abnormal coping response "altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:Rat Genome Database submission]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clcn1m1Anu/Clcn1m1Anu
Genetic Background: involves: C57BL/6 * CBA/H

 MP:0005040 abnormal MHC II cell surface expression on macrophages "anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31326]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Stat1m2Btlr/Stat1m2Btlr
Genetic Background: C57BL/6J-Stat1m2Btlr

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129S-Stat1tm1Dlv

Allelic Composition: Stat1m3Btlr/Stat1m3Btlr
Genetic Background: C57BL/6J-Stat1m3Btlr

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3wil/Jak3wil
Genetic Background: C57BL/6JSfdAnu-Jak3wil/Anu

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stat1m2Btlr/Stat1m2Btlr
Genetic Background: C57BL/6J-Stat1m2Btlr

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129S-Stat1tm1Dlv

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129S-Stat1tm1Dlv

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

 MP:0008791 decreased NK cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1m2Btlr/Stat1m2Btlr
Genetic Background: C57BL/6J-Stat1m2Btlr

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129/Sv

 MP:0009785 altered susceptibility to infection induced morbidity/mortality "differences from the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0010537 tumor regression "a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrp1B-w/Tyrp1B-w
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129S-Stat1tm1Dlv

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0010964 increased compact bone volume 
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds
Genetic Background: 129S6/SvEv-Stat1tm1Rds/Tac

 MP:0011076 increased macrophage nitric oxide production "greater production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Etv6tm1.1(RUNX1,hsb5)Lvdw/Etv6+,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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