ENSMUSG00000002147


Mus musculus

Features
Gene ID: ENSMUSG00000002147
  
Biological name :Stat6
  
Synonyms : P52633 / Signal transducer and transcription activator 6 / Stat6
  
Possible biological names infered from orthology : P42226 / signal transducer and activator of transcription 6
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 127642986
Gene end: 127660957
  
Corresponding Affymetrix probe sets: 10366956 (MoGene1.0st)   1421708_a_at (Mouse Genome 430 2.0 Array)   1426353_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112722
Ensembl peptide - ENSMUSP00000089708
NCBI entrez gene - 20852     See in Manteia.
MGI - MGI:103034
RefSeq - NM_009284
RefSeq Peptide - NP_033310
swissprot - D3YU28
swissprot - P52633
Ensembl - ENSMUSG00000002147
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat6ENSDARG00000015902Danio rerio
 STAT6ENSG00000166888Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*ENSMUSG0000002091935
P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*ENSMUSG0000000404334
Stat4 / signal transducer and activator of transcription 4 / Q14765*ENSMUSG0000006293922
Stat1 / signal transducer and activator of transcription 1 / P42224*ENSMUSG0000002610422
Stat2 / signal transducer and activator of transcription 2 / P52630*ENSMUSG0000004003321
Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*ENSMUSG0000000404021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR028187  STAT6, C-terminal
 IPR035857  STAT6, SH2 domain
 IPR036535  STAT transcription factor, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0002296 T-helper 1 cell lineage commitment IGI
 biological_processGO:0002829 negative regulation of type 2 immune response IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IMP
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035771 interleukin-4-mediated signaling pathway IMP
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048295 positive regulation of isotype switching to IgE isotypes IGI
 biological_processGO:0060443 mammary gland morphogenesis IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:1902170 cellular response to reactive nitrogen species IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Downstream signal transduction
STAT6-mediated induction of chemokines
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
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Allelic Composition: Icostm1Flv/Icostm1Flv,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Pcsk4tm1Mbi/Pcsk4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Pcsk4tm1Mbi/Pcsk4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Mylktm1.1Bph/Mylktm1.2Bph,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0001573 abnormal circulating alanine transaminase level "aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fbn1Tsk/Fbn1+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/10 * DBA/2

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiz+,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: d-100H/Myo5ad
Genetic Background: involves: C3H/HeH

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pcsk4tm1Mbi/Pcsk4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pcsk4tm1Mbi/Pcsk4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru,Tg(Scgb1a1-Il13)2Eli/?,Tg(Scgb1a1-STAT6)1Erle/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcsk4tm1Mbi/Pcsk4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002334 abnormal airway responsiveness "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pcsk4tm1Mbi/Pcsk4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbn1Tsk/Fbn1+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/10 * DBA/2

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbn1Tsk/Fbn1+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/10 * DBA/2

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: 129S2/SvPas-Stat6tm1Gru

Allelic Composition: Il4tm1.1Wep/Il4+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Fbn1Tsk/Fbn1+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/10 * DBA/2

 MP:0002503 abnormal histamine physiology "functional anomaly of this amine that is involved in local immune response, in regulating physiological function in the gut, and that acts as a neurotransmitter" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3tm1Tch/Y,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Foxp3tm1Tch

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs1tm1Kish/Socs1tm1Kish,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0004481 abnormal conjunctival epithelium "any structural anomaly in the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxrgtm2Ysa/Rxrgtm2Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004881 abnormal lung size "anomaly in the size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcsk4tm1Mbi/Pcsk4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

Allelic Composition: Nfkbiztm1Aki/Nfkbiz+,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxp3tm1Tch/Y
Genetic Background: B6.129X1-Foxp3tm1Tch

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm1(Wnt1)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: 129S2/SvPas-Stat6tm1Gru

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008091 decreased T-helper 2 cell number "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: 129S2/SvPas-Stat6tm1Gru

Allelic Composition: Il4tm1.1Wep/Il4+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Stat4tm1Jni/Stat4tm1Jni,Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: 129S2/SvPas-Stat6tm1Gru

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Foxp3tm1Tch/Y,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Foxp3tm1Tch

 MP:0008588 abnormal circulating interleukin level "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0008601 abnormal circulating interleukin-4 level "anomaly in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0008625 abnormal circulating interleukin-5 level "anomaly in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: 129S2/SvPas-Stat6tm1Gru

Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Stat4tm1Jni/Stat4tm1Jni,Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Fbn1Tsk/Fbn1+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/10 * DBA/2

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: 129S2/SvPas-Stat6tm1Gru

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1.1Wep/Il4+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0008724 impaired eosinophil migration "defect in the ability of eosinophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Jni/Stat6tm1Jni
Genetic Background: involves: 129S/SvEv

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas

 MP:0010064 increased circulating creatine level "increase in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0010174 decreased mammary gland epithelium proliferation "decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas

 MP:0010942 abnormal respiratory epithelium morphology "any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129S2-Stat6tm1Gru

Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Foxp3tm1Tch/Y,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Foxp3tm1Tch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / complex / reaction
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / reaction / complex
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / reaction / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000017057 O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*  / reaction / complex
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / reaction / complex
 ENSMUSG00000020383 Il13 / P20109 / Interleukin-13 / P35225*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000024349 Q3TBT3 / Tmem173 / Stimulator of interferons protein / Q86WV6* / transmembrane protein 173*  / complex / reaction






 

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