ENSMUSG00000030748


Mus musculus

Features
Gene ID: ENSMUSG00000030748
  
Biological name :Il4ra
  
Synonyms : Il4ra / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / P16382
  
Possible biological names infered from orthology : IL4R / interleukin 4 receptor / P24394
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 125552120
Gene end: 125579474
  
Corresponding Affymetrix probe sets: 10557326 (MoGene1.0st)   1421034_a_at (Mouse Genome 430 2.0 Array)   1423996_a_at (Mouse Genome 430 2.0 Array)   1447858_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145725
Ensembl peptide - ENSMUSP00000146185
Ensembl peptide - ENSMUSP00000145824
Ensembl peptide - ENSMUSP00000033004
NCBI entrez gene - 16190     See in Manteia.
MGI - MGI:105367
RefSeq - NM_001008700
RefSeq Peptide - NP_001008700
swissprot - A0A0U1RNW1
swissprot - A0A0U1RPZ6
swissprot - P16382
swissprot - Q3U905
Ensembl - ENSMUSG00000030748
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000035447Gallus gallus
 IL4RENSG00000077238Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015319  Interleukin-4 receptor alpha, N-terminal
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002532 production of molecular mediator involved in inflammatory response IEA
 biological_processGO:0002639 positive regulation of immunoglobulin production IMP
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0043032 positive regulation of macrophage activation IMP
 biological_processGO:0043306 positive regulation of mast cell degranulation IMP
 biological_processGO:0045626 negative regulation of T-helper 1 cell differentiation IGI
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IGI
 biological_processGO:0090197 positive regulation of chemokine secretion IMP
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4ratm2Tch/Il4ratm2Tch
Genetic Background: C.129X1-Il4ratm2Tch

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
Show

Allelic Composition: Fbn1Tsk/Fbn1+,Il4ratm1Sz/Il4ratm1Sz
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2

Allelic Composition: Fbn1Tsk/Fbn1+,Il4ratm1Sz/Il4ra+
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Fbn1Tsk/Fbn1+,Il4ratm1Sz/Il4ra+
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Cacna2d4lob/Cacna2d4lob
Genetic Background: involves: A/J * C57BL/10

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacna2d4lob/Cacna2d4lob
Genetic Background: involves: A/J * C57BL/10

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Il4ratm2Tch/Il4ratm2Tch
Genetic Background: C.129X1-Il4ratm2Tch

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna2d4lob/Cacna2d4lob
Genetic Background: involves: A/J * C57BL/10

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Shc1tm6Paw/Shc1tm6Paw,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Il4ratm2Tch/Il4ratm2Tch
Genetic Background: C.129X1-Il4ratm2Tch

Allelic Composition: Il4ratm2Tch/Il4ratm2Tch,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/?
Genetic Background: B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0002434 abnormal T helper 2 morphology/development "anomalous structure, formation, or numbers of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses. These cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Il4ratm2Tch/Il4ratm2Tch
Genetic Background: C.129X1-Il4ratm2Tch

Allelic Composition: Il4ratm3.1Tch/Il4ratm3.1Tch
Genetic Background: C.129X1-Il4ratm3.1Tch

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Fbn1Tsk/Fbn1+,Il4ratm1Sz/Il4ra+
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm2Tch/Il4ratm2Tch
Genetic Background: C.129X1-Il4ratm2Tch

Allelic Composition: Il4ratm2Tch/Il4ratm2Tch,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/?
Genetic Background: B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

Allelic Composition: Il4ratm1Sz/Il4ratm1Sz
Genetic Background: BALB/c-Il4ratm1Sz

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il4ratm2Tch/Il4ratm2Tch
Genetic Background: C.129X1-Il4ratm2Tch

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4ratm2Tch/Il4ratm2Tch
Genetic Background: C.129X1-Il4ratm2Tch

Allelic Composition: Il4ratm3.1Tch/Il4ratm3.1Tch
Genetic Background: C.129X1-Il4ratm3.1Tch

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il7rtm1.1Asin/Il7rtm1Imx,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008091 decreased T-helper 2 cell number "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbn1Tsk/Fbn1+,Il4ratm1Sz/Il4ratm1Sz
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il4ratm1Sz/Il4ratm1Sz
Genetic Background: BALB/c-Il4ratm1Sz

 MP:0008551 abnormal circulating interferon-gamma level "anomaly in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

Allelic Composition: Il4ratm2Tch/Il4ratm2Tch
Genetic Background: C.129X1-Il4ratm2Tch

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Il4ratm3.1Tch/Il4ratm3.1Tch
Genetic Background: C.129X1-Il4ratm3.1Tch

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008837 increased transforming growth factor level "greater concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/cJ

 MP:0010861 increased respiratory mucosa goblet cell number "greater number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4ratm2Tch/Il4ratm2Tch
Genetic Background: C.129X1-Il4ratm2Tch

Allelic Composition: Il4ratm2Tch/Il4ratm2Tch,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/?
Genetic Background: B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0011075 abnormal macrophage activation involved in immune response "anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281]
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Allelic Composition: Il4ratm3.1Tch/Il4ratm3.1Tch
Genetic Background: C.129X1-Il4ratm3.1Tch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / reaction / complex
 ENSMUSG00000020383 Il13 / P20109 / Interleukin-13 / P35225*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000017057 O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*  / reaction / complex
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / reaction / complex
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / reaction / complex
 ENSMUSG00000037104 Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*  / complex / reaction






 

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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr