ENSMUSG00000037104


Mus musculus

Features
Gene ID: ENSMUSG00000037104
  
Biological name :Socs5
  
Synonyms : O54928 / Socs5 / Suppressor of cytokine signaling 5
  
Possible biological names infered from orthology : O75159
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 87107679
Gene end: 87137583
  
Corresponding Affymetrix probe sets: 10447356 (MoGene1.0st)   1423349_at (Mouse Genome 430 2.0 Array)   1423350_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038591
NCBI entrez gene - 56468     See in Manteia.
MGI - MGI:2385459
RefSeq - XM_006524675
RefSeq - NM_019654
RefSeq - XM_006524672
RefSeq - XM_006524674
RefSeq - XM_006524671
RefSeq Peptide - NP_062628
swissprot - O54928
Ensembl - ENSMUSG00000037104
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs5aENSDARG00000100717Danio rerio
 socs5bENSDARG00000062745Danio rerio
 SOCS5ENSGALG00000010016Gallus gallus
 SOCS5ENSG00000171150Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Socs4 / Q91ZA6 / Suppressor of cytokine signaling 4 / Q8WXH5*ENSMUSG0000004837943
Socs6 / Q9JLY0 / Suppressor of cytokine signaling 6 / O14544*ENSMUSG0000005615320
Socs7 / Q8VHQ2 / Suppressor of cytokine signaling 7 / O14512*ENSMUSG0000003848517
Cish / Q62225 / Cytokine-inducible SH2-containing protein / Q9NSE2*ENSMUSG0000003257811
Socs2 / O35717 / suppressor of cytokine signaling 2 / O14508*ENSMUSG0000002002711
Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*ENSMUSG000000531139
Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*ENSMUSG000000380378


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR022252  SOCS4/SOCS5 domain
 IPR028420  Suppressor of cytokine signalling 5
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily
 IPR037343  SOCS5, SOCS box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0009968 negative regulation of signal transduction NAS
 biological_processGO:0016049 cell growth NAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IDA
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation IDA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IMP
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IMP
 biological_processGO:0097699 vascular endothelial cell response to fluid shear stress IMP
 biological_processGO:1904988 negative regulation of endothelial cell activation IC
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019210 kinase inhibitor activity NAS
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction / complex
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000017057 O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*  / reaction / complex
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / complex / reaction






 

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