ENSGALG00000010016


Gallus gallus

Features
Gene ID: ENSGALG00000010016
  
Biological name :SOCS5
  
Synonyms : SOCS5 / suppressor of cytokine signaling 5
  
Possible biological names infered from orthology : O54928 / O75159
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 26905251
Gene end: 26910789
  
Corresponding Affymetrix probe sets: GgaAffx.20787.1.S1_at (Chicken Array)   GgaAffx.6294.1.A1_at (Chicken Array)   GgaAffx.6294.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016250
NCBI entrez gene - 428570     See in Manteia.
RefSeq - NM_001127314
RefSeq - XM_015283738
RefSeq - XM_015283739
RefSeq Peptide - NP_001120786
swissprot - B2WUP1
Ensembl - ENSGALG00000010016
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs5aENSDARG00000100717Danio rerio
 socs5bENSDARG00000062745Danio rerio
 SOCS5ENSG00000171150Homo sapiens
 Socs5ENSMUSG00000037104Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOCS4 / suppressor of cytokine signaling 4 / Q8WXH5* / Q91ZA6*ENSGALG0000001217942
SOCS6 / suppressor of cytokine signaling 6 / O14544* / Q9JLY0*ENSGALG0000001373121
SOCS7* / O14512* / Q8VHQ2* / suppressor of cytokine signaling 7*ENSGALG0000004065815
CISH / cytokine-inducible SH2-containing protein / Q62225* / Q9NSE2*ENSGALG0000000226012
SOCS3 / suppressor of cytokine signaling 3 / O14543* / O35718*ENSGALG000000277869
SOCS1 / suppressor of cytokine signaling 1 / O15524* / O35716*ENSGALG000000071589
SOCS2 / suppressor of cytokine signaling 2 / O14508* / O35717*ENSGALG000000112959
SOCS1L / uncharacterized protein LOC417978 ENSGALG000000231937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR022252  SOCS4/SOCS5 domain
 IPR028420  Suppressor of cytokine signalling 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IEA
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:0097699 vascular endothelial cell response to fluid shear stress IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr