ENSGALG00000007158


Gallus gallus

Features
Gene ID: ENSGALG00000007158
  
Biological name :SOCS1
  
Synonyms : SOCS1 / suppressor of cytokine signaling 1
  
Possible biological names infered from orthology : O15524 / O35716
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 8984236
Gene end: 8984944
  
Corresponding Affymetrix probe sets: Gga.10606.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011581
NCBI entrez gene - 416630     See in Manteia.
RefSeq - NM_001137648
RefSeq - XM_015294233
RefSeq Peptide - NP_001131120
swissprot - B6RCQ2
Ensembl - ENSGALG00000007158
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs1aENSDARG00000038095Danio rerio
 SOCS1ENSG00000185338Homo sapiens
 Socs1ENSMUSG00000038037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOCS3 / suppressor of cytokine signaling 3 / O14543* / O35718*ENSGALG0000002778630
CISH / cytokine-inducible SH2-containing protein / Q62225* / Q9NSE2*ENSGALG0000000226030
SOCS1L / uncharacterized protein LOC417978 ENSGALG0000002319330
SOCS2 / suppressor of cytokine signaling 2 / O14508* / O35717*ENSGALG0000001129527
SOCS5 / suppressor of cytokine signaling 5 / O54928* / O75159*ENSGALG0000001001624
SOCS6 / suppressor of cytokine signaling 6 / O14544* / Q9JLY0*ENSGALG0000001373124
SOCS4 / suppressor of cytokine signaling 4 / Q8WXH5* / Q91ZA6*ENSGALG0000001217924
SOCS7* / O14512* / Q8VHQ2* / suppressor of cytokine signaling 7*ENSGALG0000004065820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028411  Suppressor of cytokine signalling 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / complex / reaction
 ENSGALG00000030661 STAT2 / signal transducer and activator of transcription 2 / P52630*  / complex
 ENSGALG00000015062 IFNK* / IFNA6* / IFNA7* / IFNA8* / Ifna9* / Ifnab* / IFNW1* / IFNA2* / IFNA4* / IFNA1* / IFNA5* / Q9P0W0* / IFNA10* / Ifna11* / Ifna12* / IFNA13* / IFNA14* / Ifna15* / IFNA16* / IFNA17* / I...  / complex
 ENSGALG00000009903 IFNG / P49708 / Interferon gamma / P01579* / P01580*  / reaction / complex
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / reaction / complex






 

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