ENSDARG00000038095


Danio rerio

Features
Gene ID: ENSDARG00000038095
  
Biological name :socs1a
  
Synonyms : socs1a / suppressor of cytokine signaling 1a
  
Possible biological names infered from orthology : O15524 / O35716 / SOCS1 / suppressor of cytokine signaling 1
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 26813058
Gene end: 26814953
  
Corresponding Affymetrix probe sets: Dr.6531.1.A1_at (Zebrafish Array)   Dr.6531.2.S1_at (Zebrafish Array)   NM_001003467_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000055536
Ensembl peptide - ENSDARP00000157344
NCBI entrez gene - 445073     See in Manteia.
RefSeq - NM_001003467
RefSeq Peptide - NP_001003467
swissprot - Q6DEF9
ZFIN ID - ZDB-GENE-040801-205
Ensembl - ENSDARG00000038095
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOCS1ENSGALG00000007158Gallus gallus
 SOCS1ENSG00000185338Homo sapiens
 Socs1ENSMUSG00000038037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
socs1b / suppressor of cytokine signaling 1bENSDARG0000008987339
socs3a / suppressor of cytokine signaling 3a / SOCS3* / O14543* / suppressor of cytokine signaling 3*ENSDARG0000002542832
socs3b / suppressor of cytokine signaling 3b / SOCS3* / O35718* / O14543* / suppressor of cytokine signaling 3*ENSDARG0000002661130
cishb / cytokine inducible SH2-containing protein b / CISH* / Q62225* / Q9NSE2* / cytokine inducible SH2 containing protein*ENSDARG0000001677327
socs2 / suppressor of cytokine signaling 2 / O14508* / O35717*ENSDARG0000004555727
cish / cytokine inducible SH2-containing protein / Q62225* / Q9NSE2*ENSDARG0000006031626
socs6a / suppressor of cytokine signaling 6a / SOCS6* / O14544* / suppressor of cytokine signaling 6*ENSDARG0000005856525
socs9 / suppressor of cytokine signaling 9ENSDARG0000010198525
socs5b / suppressor of cytokine signaling 5b / SOCS5* / O75159* / O54928* / suppressor of cytokine signaling 5*ENSDARG0000006274525
socs7 / suppressor of cytokine signaling 7 / O14512*ENSDARG0000007701825
socs5a / suppressor of cytokine signaling 5a / SOCS5* / O75159* / O54928* / suppressor of cytokine signaling 5*ENSDARG0000010071724
socs4 / suppressor of cytokine signaling 4ENSDARG0000007850922
socs6b / suppressor of cytokine signaling 6bENSDARG0000001586322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028411  Suppressor of cytokine signalling 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:0051896 regulation of protein kinase B signaling IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hemorrhagic , abnormal
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 ZFA:0000094 blood island blood island distended , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye apoptotic , abnormal
eye hemorrhagic , abnormal
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 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm increased amount , abnormal
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 ZFA:0000123 liver liver increased amount , abnormal
liver decreased amount , abnormal
liver regulation of tyrosine phosphorylation of STAT protein disrupted , abnormal
liver lipid droplet increased amount , abnormal
liver cellular response to insulin stimulus decreased process quality , abnormal
liver cellular response to glucagon stimulus decreased process quality , abnormal
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 ZFA:0000242 male organism male organism has extra parts of type liver lipid droplet, abnormal
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 ZFA:0000303 female organism female organism has extra parts of type liver lipid droplet, abnormal
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 ZFA:0001078 thymus thymus decreased size , abnormal
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 ZFA:0001094 whole organism whole organism increased length , abnormal
whole organism increased weight , abnormal
whole organism increased size , abnormal
whole organism growth increased rate , abnormal
whole organism amount , ameliorated
whole organism increased amount , abnormal
whole organism decreased amount , abnormal
whole organism decreased weight , abnormal
whole organism decreased size , abnormal
whole organism morbidity , abnormal
whole organism growth decreased rate , abnormal
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 ZFA:0005654 blood plasma blood plasma increased amount , abnormal
blood plasma response to insulin decreased process quality , abnormal
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 ZFA:0005762 subcutaneous fat subcutaneous fat decreased amount , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell increased amount , abnormal
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 ZFA:0009141 macrophage macrophage increased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte morphology , abnormal
nucleate erythrocyte increased amount , abnormal
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 ZFA:0009265 monocyte monocyte increased amount , abnormal
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 ZFA:0009309 leukocyte leukocyte proportionality to nucleate erythrocyte , abnormal
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 ZFA:0009327 neutrophil neutrophil increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037980 elob / elongin B / Elobl* / P62869* / Q15370*  / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSDARG00000045359 elocb / elongin C paralog b / ELOC* / P83940* / Q15369* / elongin C*  / complex
 ENSDARG00000069742 cul5a / cullin 5a / CUL5* / Q93034* / cullin 5*  / complex
 ENSDARG00000004260 cul5b / cullin 5b / CUL5* / Q93034* / cullin 5*  / complex






 

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