ENSDARG00000069742


Danio rerio

Features
Gene ID: ENSDARG00000069742
  
Biological name :cul5a
  
Synonyms : cul5a / cullin 5a
  
Possible biological names infered from orthology : CUL5 / cullin 5 / Q93034
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 17147002
Gene end: 17169935
  
Corresponding Affymetrix probe sets: Dr.10370.1.S1_at (Zebrafish Array)   Dr.6630.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000100474
NCBI entrez gene - 327215     See in Manteia.
swissprot - F1REN0
ZFIN ID - ZDB-GENE-030131-5426
Ensembl - ENSDARG00000069742
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CUL5ENSGALG00000017165Gallus gallus
 CUL5ENSG00000166266Homo sapiens
 Cul5ENSMUSG00000032030Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cul5b / cullin 5b / CUL5* / Q93034* / cullin 5*ENSDARG0000000426095
cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*ENSDARG0000001923929
cul1b / cullin 1b / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*ENSDARG0000000769129
cul4b / cullin 4B / A2A432* / Q13620*ENSDARG0000006051026
cul2 / cullin 2 / Q13617* / Q9D4H8*ENSDARG0000001396526
cul3b / cullin 3b / CUL3* / Q13618* / Q9JLV5* / cullin 3*ENSDARG0000010010823
cul3a / cullin 3a / CUL3* / Q13618* / Q9JLV5* / cullin 3*ENSDARG0000003896723
cul4a / cullin 4A / Q13619* / Q3TCH7*ENSDARG0000009657821


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR011991  ArsR-like helix-turn-helix domain
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex IBA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2 signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037980 elob / elongin B / Elobl* / P62869* / Q15370*  / complex
 ENSDARG00000045359 elocb / elongin C paralog b / ELOC* / P83940* / Q15369* / elongin C*  / complex
 ENSDARG00000038095 socs1a / suppressor of cytokine signaling 1a / SOCS1* / O35716* / O15524* / suppressor of cytokine signaling 1*  / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSDARG00000026611 socs3b / suppressor of cytokine signaling 3b / SOCS3* / O35718* / O14543* / suppressor of cytokine signaling 3*  / complex
 ENSDARG00000025428 socs3a / suppressor of cytokine signaling 3a / SOCS3* / O14543* / suppressor of cytokine signaling 3*  / complex
 ENSDARG00000096306 si:ch1073-342h5.2 / LRRC41* / Q15345* / Q8K1C9* / leucine rich repeat containing 41* / Leucine-rich repeat-containing protein 41 *  / complex
 ENSDARG00000007989 nedd8 / neural precursor cell expressed, developmentally down-regulated 8 / P29595* / Q15843*  / complex






 

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