ENSDARG00000007989


Danio rerio

Features
Gene ID: ENSDARG00000007989
  
Biological name :nedd8
  
Synonyms : nedd8 / neural precursor cell expressed, developmentally down-regulated 8
  
Possible biological names infered from orthology : P29595 / Q15843
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 24205034
Gene end: 24207788
  
Corresponding Affymetrix probe sets: Dr.8388.1.S1_at (Zebrafish Array)   NM_201321_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000021095
NCBI entrez gene - 368667     See in Manteia.
RefSeq - NM_201321
RefSeq Peptide - NP_958478
swissprot - F1QMF9
ZFIN ID - ZDB-GENE-030616-588
Ensembl - ENSDARG00000007989
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NEDD8ENSG00000129559Homo sapiens
 Nedd8ENSMUSG00000010376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nedd8l / neural precursor cell expressed, developmentally down-regulated 8, like / NEDD8* / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*ENSDARG0000010347285


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR019954  Ubiquitin conserved site
 IPR019956  Ubiquitin
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
No match


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling activates SMADs
UCH proteinases
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019595 senp8 / SUMO/sentrin peptidase family member, NEDD8 specific / Q96LD8* / Q9D2Z4* / Sentrin-specific protease 8 *  / complex
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSDARG00000096578 cul4a / cullin 4A / Q13619* / Q3TCH7*  / complex / reaction
 ENSDARG00000057987 uba3 / Q7ZVX6 / ubiquitin-like modifier activating enzyme 3 / Q8C878* / Q8TBC4*  / reaction / complex
 ENSDARG00000034541 tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*  / reaction / complex
 ENSDARG00000007989 nedd8 / neural precursor cell expressed, developmentally down-regulated 8 / P29595* / Q15843*  / reaction / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSDARG00000031203 commd1 / copper metabolism (Murr1) domain containing 1 / Q8K4M5* / Q8N668* / Gm28048* / COMM domain-containing protein 1 * / copper metabolism domain containing 1*  / complex / reaction
 ENSDARG00000025754 ube2f / Q6NY82 / ubiquitin-conjugating enzyme E2F (putative) / Q969M7* / Q9CY34* / UBE2F-SCLY* / UBE2F-SCLY readthrough (NMD candidate)*  / complex / reaction
 ENSDARG00000059363 tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*  / reaction / complex
 ENSDARG00000060510 cul4b / cullin 4B / A2A432* / Q13620*  / complex / reaction
 ENSDARG00000038967 cul3a / cullin 3a / CUL3* / Q13618* / Q9JLV5* / cullin 3*  / complex
 ENSDARG00000057624 cops5 / Q6PC30 / COP9 signalosome subunit 5 / O35864* / Q92905* / COP9 signalosome complex subunit 5 *  / reaction
 ENSDARG00000030177 uchl3 / ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) / Uchl4* / Q9JKB1* / P58321* / P15374* / ubiquitin C-terminal hydrolase L3* / ubiquitin carboxyl-terminal esterase L4*  / complex
 ENSDARG00000069742 cul5a / cullin 5a / CUL5* / Q93034* / cullin 5*  / complex
 ENSDARG00000043046 fbxl5 / F-box and leucine-rich repeat protein 5 / Q8C2S5* / Q9UKA1* / F-box/LRR-repeat protein 5 *  / reaction / complex
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000004260 cul5b / cullin 5b / CUL5* / Q93034* / cullin 5*  / complex
 ENSDARG00000013965 cul2 / cullin 2 / Q13617* / Q9D4H8*  / complex
 ENSDARG00000100108 cul3b / cullin 3b / CUL3* / Q13618* / Q9JLV5* / cullin 3*  / complex






 

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