ENSDARG00000030177


Danio rerio

Features
Gene ID: ENSDARG00000030177
  
Biological name :uchl3
  
Synonyms : ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) / uchl3
  
Possible biological names infered from orthology : P15374 / P58321 / Q9JKB1 / ubiquitin carboxyl-terminal esterase L4 / ubiquitin C-terminal hydrolase L3 / Uchl4
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 21971260
Gene end: 21976670
  
Corresponding Affymetrix probe sets: Dr.16889.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000095097
NCBI entrez gene - 554104     See in Manteia.
swissprot - Q504C0
ZFIN ID - ZDB-GENE-050522-158
Ensembl - ENSDARG00000030177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UCHL3ENSGALG00000016921Gallus gallus
 UCHL3ENSG00000118939Homo sapiens
 Uchl3ENSMUSG00000022111Mus musculus
 Uchl4ENSMUSG00000035337Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
uchl1 / ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) / Q9R0P9* / P09936* / ubiquitin C-terminal hydrolase L1* / ubiquitin carboxy-terminal hydrolase L1*ENSDARG0000002687148


Protein motifs (from Interpro)
Interpro ID Name
 IPR001578  Peptidase C12, ubiquitin carboxyl-terminal hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007219 Notch signaling pathway IMP
 biological_processGO:0016579 protein deubiquitination IBA
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
UCH proteinases
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000135 notochord notochord malformed , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001115 trunk trunk necrotic , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch decreased distribution , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage absent , abnormal
ethmoid cartilage decreased distribution , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
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 ZFA:0009248 neuron neuron hyperplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000041435 uba52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSDARG00000007989 nedd8 / neural precursor cell expressed, developmentally down-regulated 8 / P29595* / Q15843*  / complex
 ENSDARG00000032725 rps27a / ribosomal protein S27a / P62979* / P62983* / AL136454.1*  / reaction






 

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