ENSMUSG00000022111


Mus musculus

Features
Gene ID: ENSMUSG00000022111
  
Biological name :Uchl3
  
Synonyms : Q9JKB1 / ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) / Uchl3
  
Possible biological names infered from orthology : P15374 / ubiquitin C-terminal hydrolase L3
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: E2.3
Gene start: 101653967
Gene end: 101696125
  
Corresponding Affymetrix probe sets: 10416793 (MoGene1.0st)   1449855_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002289
Ensembl peptide - ENSMUSP00000154032
NCBI entrez gene - 50933     See in Manteia.
MGI - MGI:1355274
RefSeq - XM_006519248
RefSeq - NM_016723
RefSeq - XM_006519246
RefSeq - XM_006519247
RefSeq Peptide - NP_057932
swissprot - Q9JKB1
Ensembl - ENSMUSG00000022111
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uchl3ENSDARG00000030177Danio rerio
 UCHL3ENSGALG00000016921Gallus gallus
 UCHL3ENSG00000118939Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Uchl4 / P58321 / ubiquitin carboxyl-terminal esterase L4 / UCHL3* / P15374* / ubiquitin C-terminal hydrolase L3*ENSMUSG0000003533797
Uchl1 / Q9R0P9 / ubiquitin carboxy-terminal hydrolase L1 / P09936* / ubiquitin C-terminal hydrolase L1*ENSMUSG0000002922353


Protein motifs (from Interpro)
Interpro ID Name
 IPR001578  Peptidase C12, ubiquitin carboxyl-terminal hydrolase
 IPR036959  Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007628 adult walking behavior IGI
 biological_processGO:0016579 protein deubiquitination ISA
 biological_processGO:0030163 protein catabolic process IDA
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0042755 eating behavior IGI
 biological_processGO:0045600 positive regulation of fat cell differentiation IDA
 biological_processGO:0060041 retina development in camera-type eye IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0043130 ubiquitin binding ISO
 molecular_functionGO:0101005 ubiquitinyl hydrolase activity IDA


Pathways (from Reactome)
Pathway description
UCH proteinases
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Uchl1gad/Uchl1gad,Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/Nga * RFM/Nga

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uchl1gad/Uchl1gad,Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/Nga * RFM/Nga

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uchl1gad/Uchl1gad,Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/Nga * RFM/Nga

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Terttm1Rdp/Terttm1Rdp
Genetic Background: B6.Cg-Terttm1Rdp

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Uchl1gad/Uchl1gad,Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/Nga * RFM/Nga

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Uchl1gad/Uchl1gad,Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/Nga * RFM/Nga

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp
Genetic Background: B6.Cg-Terttm1Rdp

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0003158 dysphagia "difficulty in swallowing food or liquid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Uchl1gad/Uchl1gad,Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/Nga * RFM/Nga

 MP:0003225 axonal dystrophy "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uchl1gad/Uchl1gad,Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/Nga * RFM/Nga

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003730 abnormal photoreceptor inner segments "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Uchl1gad/Uchl1gad,Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/Nga * RFM/Nga

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020460 P62983 / Rps27a / ribosomal protein S27A / P62979*  / reaction
 ENSMUSG00000068240 P62984 / Gm11808 / predicted gene 11808 / UBA52* / P62987* / ubiquitin A-52 residue ribosomal protein fusion product 1*  / reaction
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex






 

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