ENSG00000118939


Homo sapiens

Features
Gene ID: ENSG00000118939
  
Biological name :UCHL3
  
Synonyms : P15374 / ubiquitin C-terminal hydrolase L3 / UCHL3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q22.2
Gene start: 75549480
Gene end: 75606020
  
Corresponding Affymetrix probe sets: 204616_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398189
Ensembl peptide - ENSP00000477746
Ensembl peptide - ENSP00000366819
NCBI entrez gene - 7347     See in Manteia.
OMIM - 603090
RefSeq - XM_017020727
RefSeq - NM_006002
RefSeq - XM_011535212
RefSeq - XM_011535213
RefSeq - XM_011535214
RefSeq - XM_017020725
RefSeq - XM_017020726
RefSeq - NM_001270952
RefSeq Peptide - NP_001257881
RefSeq Peptide - NP_005993
swissprot - A0A140VJZ4
swissprot - Q5TBK7
swissprot - A0A087WTB8
swissprot - P15374
Ensembl - ENSG00000118939
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uchl3ENSDARG00000030177Danio rerio
 UCHL3ENSGALG00000016921Gallus gallus
 Uchl3ENSMUSG00000022111Mus musculus
 Uchl4ENSMUSG00000035337Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UCHL1 / P09936 / ubiquitin C-terminal hydrolase L1ENSG0000015427753


Protein motifs (from Interpro)
Interpro ID Name
 IPR001578  Peptidase C12, ubiquitin carboxyl-terminal hydrolase
 IPR036959  Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016579 protein deubiquitination IBA
 biological_processGO:0030163 protein catabolic process IDA
 biological_processGO:0043687 post-translational protein modification TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019784 NEDD8-specific protease activity TAS
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0043130 ubiquitin binding IDA


Pathways (from Reactome)
Pathway description
UCH proteinases
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / complex
 ENSG00000143947 P62979 / RPS27A / ribosomal protein S27a  / reaction
 ENSG00000221983 UBA52 / P62987 / ubiquitin A-52 residue ribosomal protein fusion product 1  / reaction






 

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