ENSDARG00000003151


Danio rerio

Features
Gene ID: ENSDARG00000003151
  
Biological name :skp1
  
Synonyms : skp1 / S-phase kinase-associated protein 1
  
Possible biological names infered from orthology : AC104109.3 / P63208 / Q9WTX5 / Skp1a / S-phase kinase-associated protein 1A
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 45341786
Gene end: 45349548
  
Corresponding Affymetrix probe sets: Dr.14551.1.S1_at (Zebrafish Array)   NM_200743_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000015887
Ensembl peptide - ENSDARP00000146397
NCBI entrez gene - 393716     See in Manteia.
RefSeq - NM_200743
RefSeq Peptide - NP_957037
swissprot - Q6PBY8
ZFIN ID - ZDB-GENE-040426-1707
Ensembl - ENSDARG00000003151
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SKP1ENSGALG00000006474Gallus gallus
 AC104109.3ENSG00000272772Homo sapiens
 SKP1ENSG00000113558Homo sapiens
 Skp1aENSMUSG00000036309Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001232  S-phase kinase-associated protein 1-like
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR016072  SKP1 component, dimerisation
 IPR016073  SKP1 component, POZ domain
 IPR016897  S-phase kinase-associated protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk circular , abnormal
yolk grey , abnormal
yolk quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye necrotic , abnormal
Show

 ZFA:0000112 gut gut hypoplastic , abnormal
gut quality , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000123 liver liver hypoplastic , abnormal
liver quality , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head necrotic , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / reaction / complex
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000015254 fzr1a / fizzy/cell division cycle 20 related 1a / FZR1* / Q9R1K5* / Q9UM11* / Fizzy-related protein homolog * / fizzy and cell division cycle 20 related 1*  / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / reaction / complex
 ENSDARG00000007989 nedd8 / neural precursor cell expressed, developmentally down-regulated 8 / P29595* / Q15843*  / complex / reaction
 ENSDARG00000038185 gh1 / growth hormone 1 / Gh* / GH2* / CSH2* / CSH1* / CSHL1* / P01242* / Q14406* / P0DML3* / P0DML2* / P01241* / P06880* / Somatotropin * / growth hormone 2* / chorionic somatomammotropin h...  / reaction / complex
 ENSDARG00000007971 cks1b / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / reaction / complex
 ENSDARG00000100741 cdc20 / cell division cycle 20 homolog / Q12834* / Q9JJ66* / Cell division cycle * / cell division cycle 20*  / complex
 ENSDARG00000011493 dcun1d3 / defective in cullin neddylation 1 domain containing 3 / Q8IWE4* / Q8K0V2* / DCN1-like protein 3 *  / reaction / complex
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / complex / reaction
 ENSDARG00000004937 skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase / Q9Z0Z3* / Q13309* / S-phase kinase associated protein 2* / S-phase kinase-associated protein 2 (p45)*  / complex
 ENSDARG00000017230 fbxw11b / F-box and WD repeat domain containing 11b / Q9UKB1* / FBXW11* / Q5SRY7* / F-box/WD repeat-containing protein 11 * / F-box and WD repeat domain containing 11*  / complex
 ENSDARG00000029018 cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / reaction / complex
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / complex / reaction
 ENSDARG00000030087 nfkbib / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta / Q15653* / Q60778* / NFKB inhibitor beta* / NF-kappa-B inhibitor beta *  / complex / reaction
 ENSDARG00000061710 map3k8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / reaction / complex
 ENSDARG00000045636 rbl2 / retinoblastoma-like 2 (p130) / Q64700* / Q08999* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*  / reaction / complex
 ENSDARG00000038687 nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*  / reaction / complex
 ENSDARG00000062251 fbxl7 / A1A5X2 / F-box and leucine-rich repeat protein 7 / Q9UJT9* / Q5BJ29* / F-box/LRR-repeat protein 7 *  / reaction / complex
 ENSDARG00000055276 rel / v-rel avian reticuloendotheliosis viral oncogene homolog / Q04864* / reticuloendotheliosis oncogene* / REL proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSDARG00000054271 cdkn1bb / cyclin-dependent kinase inhibitor 1Bb / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / reaction / complex
 ENSDARG00000042688 bora / bora, aurora kinase A activator / Q6PGQ7* / Q8BS90* / Protein aurora borealis *  / complex / reaction
 ENSDARG00000074501 tnip2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / complex / reaction
 ENSDARG00000040261 runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*  / reaction / complex
 ENSDARG00000043046 fbxl5 / F-box and leucine-rich repeat protein 5 / Q8C2S5* / Q9UKA1* / F-box/LRR-repeat protein 5 *  / reaction / complex
 ENSDARG00000031203 commd1 / copper metabolism (Murr1) domain containing 1 / Q8K4M5* / Q8N668* / Gm28048* / COMM domain-containing protein 1 * / copper metabolism domain containing 1*  / complex / reaction
 ENSDARG00000076554 cdkn1a / cyclin-dependent kinase inhibitor 1A / P38936* / P39689* / Cyclin-dependent kinase inhibitor 1 *  / reaction / complex
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / reaction / complex
 ENSDARG00000104806 fbxw11a / F-box and WD repeat domain containing 11a / FBXW11* / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr