ENSDARG00000038687


Danio rerio

Features
Gene ID: ENSDARG00000038687
  
Biological name :nfkb2
  
Synonyms : nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
  
Possible biological names infered from orthology : nuclear factor kappa B subunit 2 / Q00653 / Q9WTK5
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 22717366
Gene end: 22735547
  
Corresponding Affymetrix probe sets: Dr.13012.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000057671
Ensembl peptide - ENSDARP00000121285
Ensembl peptide - ENSDARP00000121718
Ensembl peptide - ENSDARP00000154151
NCBI entrez gene - 415100     See in Manteia.
RefSeq - NM_001001840
RefSeq - XM_005156814
RefSeq - XM_009307306
RefSeq Peptide - NP_001001840
swissprot - F1R3P4
swissprot - B8A4B4
swissprot - Q0II00
ZFIN ID - ZDB-GENE-030131-6701
Ensembl - ENSDARG00000038687
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NFKB2ENSGALG00000005653Gallus gallus
 NFKB2ENSG00000077150Homo sapiens
 Nfkb2ENSMUSG00000025225Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...ENSDARG0000010526126
rel / v-rel avian reticuloendotheliosis viral oncogene homolog / Q04864* / reticuloendotheliosis oncogene* / REL proto-oncogene, NF-kB subunit*ENSDARG0000005527618
rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*ENSDARG0000009869615
relb / v-rel avian reticuloendotheliosis viral oncogene homolog B / Q04863* / Q01201* / RELB proto-oncogene, NF-kB subunit* / avian reticuloendotheliosis viral (v-rel) oncogene related B*ENSDARG0000008617315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR000488  Death domain
 IPR002110  Ankyrin repeat
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011029  Death-like domain superfamily
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR020683  Ankyrin repeat-containing domain
 IPR030492  Rel homology domain, conserved site
 IPR032397  Rel homology dimerisation domain
 IPR033926  NFkappaB IPT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0038061 NIK/NF-kappaB signaling IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm hematopoietic cell decreased amount , abnormal
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 ZFA:0001115 trunk trunk intersegmental vessel branchiness , abnormal
trunk intersegmental vessel increased branchiness , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel immature , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSDARG00000104806 fbxw11a / F-box and WD repeat domain containing 11a / FBXW11* / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex
 ENSDARG00000017230 fbxw11b / F-box and WD repeat domain containing 11b / Q9UKB1* / FBXW11* / Q5SRY7* / F-box/WD repeat-containing protein 11 * / F-box and WD repeat domain containing 11*  / reaction / complex
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000030087 nfkbib / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta / Q15653* / Q60778* / NFKB inhibitor beta* / NF-kappa-B inhibitor beta *  / complex
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / reaction / complex
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / reaction






 

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