ENSGALG00000005653


Gallus gallus

Features
Gene ID: ENSGALG00000005653
  
Biological name :NFKB2
  
Synonyms : NFKB2 / nuclear factor NF-kappa-B p100 subunit
  
Possible biological names infered from orthology : nuclear factor kappa B subunit 2 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653 / Q9WTK5
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 16936051
Gene end: 16944525
  
Corresponding Affymetrix probe sets: Gga.1057.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000042025
Ensembl peptide - ENSGALP00000062848
Ensembl peptide - ENSGALP00000046812
Ensembl peptide - ENSGALP00000009054
NCBI entrez gene - 386574     See in Manteia.
RefSeq - NM_204413
RefSeq Peptide - NP_989744
swissprot - A0A1L1RVJ0
swissprot - A0A1D5P2B7
swissprot - F1NGH3
swissprot - R4GIS9
Ensembl - ENSGALG00000005653
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfkb2ENSDARG00000038687Danio rerio
 NFKB2ENSG00000077150Homo sapiens
 Nfkb2ENSMUSG00000025225Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*ENSGALG0000001230442
REL / REL proto-oncogene, NF-kB subunit / Q04864* / reticuloendotheliosis oncogene*ENSGALG0000000784517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR000488  Death domain
 IPR002110  Ankyrin repeat
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011029  Death-like domain superfamily
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR020683  Ankyrin repeat-containing domain
 IPR030492  Rel homology domain, conserved site
 IPR032397  Rel homology dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002268 follicular dendritic cell differentiation IEA
 biological_processGO:0002467 germinal center formation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048536 spleen development IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0033257 Bcl3/NF-kappaB2 complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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