ENSMUSG00000025225


Mus musculus

Features
Gene ID: ENSMUSG00000025225
  
Biological name :Nfkb2
  
Synonyms : Nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q9WTK5
  
Possible biological names infered from orthology : nuclear factor kappa B subunit 2 / Q00653
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 46304737
Gene end: 46312090
  
Corresponding Affymetrix probe sets: 10463599 (MoGene1.0st)   1425902_a_at (Mouse Genome 430 2.0 Array)   1429128_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072859
Ensembl peptide - ENSMUSP00000107512
NCBI entrez gene - 18034     See in Manteia.
MGI - MGI:1099800
RefSeq - XM_006526743
RefSeq - NM_001177369
RefSeq - NM_001177370
RefSeq - NM_019408
RefSeq Peptide - NP_001170841
RefSeq Peptide - NP_062281
RefSeq Peptide - NP_001170840
swissprot - Q3UG25
swissprot - Q9WTK5
Ensembl - ENSMUSG00000025225
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfkb2ENSDARG00000038687Danio rerio
 NFKB2ENSGALG00000005653Gallus gallus
 NFKB2ENSG00000077150Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*ENSMUSG0000002816344
Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*ENSMUSG0000002027520
Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*ENSMUSG0000002492718
Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*ENSMUSG0000000298317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR000488  Death domain
 IPR002110  Ankyrin repeat
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011029  Death-like domain superfamily
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR020683  Ankyrin repeat-containing domain
 IPR030492  Rel homology domain, conserved site
 IPR032397  Rel homology dimerisation domain
 IPR033926  NFkappaB IPT domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0002268 follicular dendritic cell differentiation IMP
 biological_processGO:0002467 germinal center formation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IDA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048535 lymph node development TAS
 biological_processGO:0048536 spleen development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 cellular_componentGO:0033257 Bcl3/NF-kappaB2 complex ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf6tm1Jino/Traf6tm1Jino
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Map3k14tm1Rds/Map3k14tm1Rds
Genetic Background: involves: 129/Sv

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002219 decreased lymph node number "fewer than the normal number of lymph nodes " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2m1/Il2m1
Genetic Background: MRL/MpJ

Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002343 abnormal lymph node cortex "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002364 abnormal thymus size "deviation from the normal size of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Traf6tm1Jino/Traf6tm1Jino
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Traf6tm1Jino/Traf6tm1Jino
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002392 abnormal Peyer s patch T cell area "anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf6tm1Jino/Traf6tm1Jino
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0003795 abnormal bone structure 
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Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005046 failure of spleen white pulp formation "lack of development of the lymphoid area of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0005493 stomach epithelial hyperplasia 
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

Allelic Composition: Nfkb2tm1Brv/Nfkb2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006173 abnormal Langerhans cell morphology/development "anomaly in the formation or structure of phagocytic dendritic cells principally found in the epidemis and mucosal epithelium" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95147]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008122 decreased myeloid dendritic cell number "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Malt1m1Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m1Btlr

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Nfkb2tm2Brv Tg(Tnfsf13b)1Fma

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Nfkb2tm2Brv Tg(Tnfsf13b)1Fma

 MP:0008234 absent spleen marginal zone "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Nfkb2tm2Brv Tg(Tnfsf13b)1Fma

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008240 abnormal spleen marginal zone macrophage morphology "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008241 abnormal metallophilic macrophage morphology "any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008343 abnormal gamma-delta T cell morphology "any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Relatm1Rsch/Relatm1Rsch,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Relatm1Rsch/Relatm1Rsch,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008463 abnormal peripheral lymph node morphology "any structural anomaly of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008465 absent mesenteric lymph nodes "absence of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008471 abnormal spleen primary B follicle morphology "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008472 abnormal spleen secondary B follicle morphology "any strucutral anomaly of the nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

 MP:0008473 abnormal spleen follicular dendritic cell network "any structural anomaly of the enmeshed group of antigen presenting cells with extensive dendritic processes in the spleen B cell follicle that present antigen to B cells during an immune response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Nfkb2tm1Rsch/Nfkb2tm1Rsch
Genetic Background: involves: 129P2/OlaHsd

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0009322 increased splenocyte apoptosis "increase in the number of spleen cells undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0009628 absent brachial lymph nodes "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0009633 absent cervical lymph nodes "absence of the lymph nodes normally found near the neck and shoulders" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb2Lym1/Nfkb2+
Genetic Background: BALB/c-Nfkb2Lym1

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10

 MP:0010798 abnormal stomach cardiac region morphology "any structural anomaly of the stomach region where the esophagus empties into the stomach" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2+,Traf3tm1Bal/Traf3tm1Bal
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

 MP:0020416 decreased fibroblast chemotaxis "reduction in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna, PMID:20231695]
Show

Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / complex
 ENSMUSG00000031671 Setd6 / Q9CWY3 / N-lysine methyltransferase SETD6 / Q8TBK2* / SET domain containing 6*  / reaction
 ENSMUSG00000030595 Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*  / complex
 ENSMUSG00000002983 Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*  / complex
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex / reaction
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / reaction / complex






 

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