ENSMUSG00000024927


Mus musculus

Features
Gene ID: ENSMUSG00000024927
  
Biological name :Rela
  
Synonyms : Q04207 / Rela / v-rel reticuloendotheliosis viral oncogene homolog A (avian)
  
Possible biological names infered from orthology : Q04206 / RELA proto-oncogene, NF-kB subunit
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 5637483
Gene end: 5648130
  
Corresponding Affymetrix probe sets: 10460631 (MoGene1.0st)   1419536_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025867
NCBI entrez gene - 19697     See in Manteia.
MGI - MGI:103290
RefSeq - XM_006531695
RefSeq - NM_009045
RefSeq - XM_006531694
RefSeq Peptide - NP_033071
swissprot - Q548Y4
swissprot - Q04207
Ensembl - ENSMUSG00000024927
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 relaENSDARG00000098696Danio rerio
 RELAENSG00000173039Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*ENSMUSG0000002027540
Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*ENSMUSG0000000298333
Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*ENSMUSG0000002816330
Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*ENSMUSG0000002522529


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR030492  Rel homology domain, conserved site
 IPR030495  Transcription factor RelA (p65)
 IPR032397  Rel homology dimerisation domain
 IPR033926  NFkappaB IPT domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0006117 acetaldehyde metabolic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006952 defense response IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0010224 response to UV-B IEA
 biological_processGO:0014040 positive regulation of Schwann cell differentiation IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0032495 response to muramyl dipeptide IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0033234 negative regulation of protein sumoylation IDA
 biological_processGO:0033590 response to cobalamin IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0035994 response to muscle stretch IDA
 biological_processGO:0038061 NIK/NF-kappaB signaling IBA
 biological_processGO:0042177 negative regulation of protein catabolic process IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043620 regulation of DNA-templated transcription in response to stress IEA
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process IDA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0071224 cellular response to peptidoglycan IEA
 biological_processGO:0071316 cellular response to nicotine IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:2000630 positive regulation of miRNA metabolic process IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 cellular_componentGO:0035525 NF-kappaB p50/p65 complex NAS
 cellular_componentGO:0071159 NF-kappaB complex TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0042301 phosphate ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042805 actinin binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:0071532 ankyrin repeat binding IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
Interleukin-1 signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Olfr151tm25Mom/?,Olfr160tm6Mom/?,Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0000380 small hair follicles "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0000384 distorted hair follicle pattern "twisted or contorted configuration of the arrangement of hair follicles in the skin" [J:56777]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Cstbtm1Rm/Cstbtm1Rm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Relatm1Yuo/Relatm1Yuo,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S/SvEv * 129S1/SvEv

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0001220 epidermal necrosis "pathological cell death in the epidermal layer of the skin, usually due to irreversible damage" [J:65146]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp7Tg(BCL2)114Cro/Bmp7Tg(BCL2)114Cro
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scd1ab-J/Scd1ab-J
Genetic Background: B6.Cg-Ldlrtm1Her Scd1ab-J

Allelic Composition: Relatm1.1Gho/Relatm1.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scd1ab-J/Scd1ab-J
Genetic Background: B6.Cg-Ldlrtm1Her Scd1ab-J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scd1ab-J/Scd1ab-J
Genetic Background: B6.Cg-Ldlrtm1Her Scd1ab-J

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Tyrp1rgsc220/Tyrp1rgsc220
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S4-Relatm1Bal

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Relatm1.1Gho/Relatm1.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scd1ab-J/Scd1ab-J
Genetic Background: B6.Cg-Ldlrtm1Her Scd1ab-J

Allelic Composition: Relatm1.2Gho/Relatm1.2Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scd1ab-J/Scd1ab-J
Genetic Background: B6.Cg-Ldlrtm1Her Scd1ab-J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dsg4arm/Dsg4arm
Genetic Background: involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd

Allelic Composition: Relatm1Ukl/Relatm1Ukl
Genetic Background: B6.129S1-Relatm1Ukl/J

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: AK.MRL-Faslpr

Allelic Composition: Relatm1Rsch/Relatm1Rsch,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: ICR

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
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Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0002814 hyperchromasia "increased capacity of a cell to stain with dye; usually refers to staining of cell nuclei with hematoxylin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Tyrp1rgsc220/Tyrp1rgsc220
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Relatm2.1Gho/Relatm2.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0003380 abnormal intestine regeneration "deviation from the normal ability of the intestine to regenerate healthy tissue following injury" [J:93428, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Myo5argsc235/Myo5argsc235
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0003795 abnormal bone structure 
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Relatm1.1Gho/Relatm1.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S4-Relatm1Bal

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

Allelic Composition: Relatm1Bal/Relatm1Bal,Tg(SERPINA1-BCL2)1Pva/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cstbtm1Rm/Cstbtm1Rm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0008112 abnormal monocyte differentiation "atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008343 abnormal gamma-delta T cell morphology "any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Relatm1Rsch/Relatm1Rsch,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: ICR

Allelic Composition: Relatm1Rsch/Relatm1Rsch,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Relatm1Rsch/Relatm1Rsch,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: ICR

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S/SvEv * 129S1/SvEv

 MP:0009405 increased skeletal muscle fiber number "increased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm1Yuo/Relatm1Yuo,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S/SvEv * 129S1/SvEv

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Relatm1Asba/Relatm1Asba,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Relatm1Bal/Relatm1Bal,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Relatm1.1Gho/Relatm1.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S4-Relatm1Bal

Allelic Composition: Relatm1Yuo/Relatm1Yuo
Genetic Background: involves: 129S/SvEv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

Allelic Composition: Relatm1.1Gho/Relatm1.1Gho,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scd1ab-J/Scd1ab-J
Genetic Background: B6.Cg-Ldlrtm1Her Scd1ab-J

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0030582 abnormal hair follicle placode formation "any anomaly in the developmental process in which a hair placode forms; in mouse, hair placode formation is initiated at ~E13.5 in response to the first dermal signal originating from dermal fibroblasts; the resulting primary hair placode cells signal to the underlying dermis, triggering formation of dermal condensates that will coordinate further differentiation of hair-forming cells; hair placode formation progresses through 3 successive waves (1) primary hair placodes form at E14.5 and produce guard hair, (2) secondary hair placodes form at E16-17 and produce awl hair, and (3) the third wave of hair follicle induction produces tertiary placodes and generate zig-zag hair" [GO:0060789, https://discovery.lifemapsc.com/in-vivo-development/hair/hair-follicle/primary-hair-placode-cells]
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Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal,Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / complex / reaction
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / reaction
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction
 ENSMUSG00000023947 Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*  / complex
 ENSMUSG00000030595 Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*  / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000025225 Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*  / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000002983 Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / complex
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex
 ENSMUSG00000031671 Setd6 / Q9CWY3 / N-lysine methyltransferase SETD6 / Q8TBK2* / SET domain containing 6*  / reaction
 ENSMUSG00000021180 Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*  / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction






 

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