ENSMUSG00000000120


Mus musculus

Features
Gene ID: ENSMUSG00000000120
  
Biological name :Ngfr
  
Synonyms : nerve growth factor receptor / Ngfr
  
Possible biological names infered from orthology : P08138
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 95568818
Gene end: 95587735
  
Corresponding Affymetrix probe sets: 10390175 (MoGene1.0st)   1421241_at (Mouse Genome 430 2.0 Array)   1450177_at (Mouse Genome 430 2.0 Array)   1454903_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000122
NCBI entrez gene - 18053     See in Manteia.
MGI - MGI:97323
RefSeq - NM_033217
RefSeq Peptide - NP_150086
swissprot - Q8CFT3
Ensembl - ENSMUSG00000000120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngfraENSDARG00000088708Danio rerio
 ngfrbENSDARG00000089223Danio rerio
 NGFRENSGALG00000035950Gallus gallus
 NGFRENSG00000064300Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nradd / Q8CJ26 / Death domain-containing membrane protein NRADD ENSMUSG0000003249118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR022325  Tumour necrosis factor receptor 16
 IPR034046  Tumor necrosis factor receptor 16, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005035 death receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0015026 coreceptor activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
Regulated proteolysis of p75NTR
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000378 absent hair follicles "missing epidermal invaginations from which the hair shaft develops" [J:65039]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000452 abnormal mouth morphology "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000578 ulcerated paws "inflammatory, often suppurating lesions on the paws; often become necrotic" [J:17194]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0000904 abnormal superior colliculus "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm1(GAP43)Gld/Gt(ROSA)26Sor+,Ngfrtm1Klee/Ngfrtm1Klee,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Mybtm1.1Jof/Mybtm1.1Jof
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001021 small L4 ganglion "reduced size of L4 ganglion" [J:17792]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001022 abnormal L5 ganglion morphology "malformation or absence of the L5 ganglion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Ngfrtm1Jae/Ngfr+
Genetic Background: B6.129S4-Ngfrtm1Jae

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ngfrtm1Jae/Ngfr+
Genetic Background: B6.129S4-Ngfrtm1Jae

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1.1Vk/Ngfrtm1.1Vk,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA/J * FVB/N

Allelic Composition: Ngfrtm1.2Vk/Ngfrtm1.2Vk
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ngfrtm1.2Vk/Ngfrtm1.2Vk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1.1Vk/Ngfrtm1.1Vk,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA/J * FVB/N

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sema3atm1Mcf/Sema3a+
Genetic Background: involves: 129S4/SvJae

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Ngfrtm1.1Vk/Ngfrtm1.1Vk,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA/J * FVB/N

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myoz1tm1a(EUCOMM)Hmgu/Myoz1tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003201 extremity edema "an accumulation of serous fluid in the limbs, paws and tail" [RGD:Rat Genome Database submission]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ngftm1Gne/Ngf+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Ngfrtm1Jae/Ngfr+
Genetic Background: B6.129S4-Ngfrtm1Jae

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003932 abnormal molar crown morphology "defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybtm1.1Jof/Mybtm1.1Jof
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0005236 abnormal olfactory nerve morphology "anomalous structure of the first cranial nerve, which conveys the sense of smell" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Omptm1(tTA)Gogo/Omp+,Tg(tetO-tetX,lacZ)2Gogo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ngfrtm1Jae/Ngfr+,Omptm1(tTA)Gogo/Omp+,Tg(tetO-tetX,lacZ)2Gogo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Omptm1(tTA)Gogo/Omp+,Tg(tetO-tetX,lacZ)1Gogo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0006070 increased retinal photoreceptor number "greater than the expected number of rods and/or cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0006258 abnormal circumvallate papillae "malformation, absence, or atypical size or shape of the large papillae, which have multiple taste buds in the trough surrounding the papillae, located near the base and on the dorsal side of the tongue" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:55127]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0006260 abnormal gustatory papillae taste buds "malformation, absence, or atypical size or shape of the taste buds located on the gustatory papillae, which includes the fungiform, foliate, and circumvallate papillae" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:55127]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm1(GAP43)Gld/Gt(ROSA)26Sor+,Ngfrtm1Klee/Ngfrtm1Klee,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0008468 absent muscle spindles "absence of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008486 decreased muscle spindle number "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0008960 abnormal axon pruning "defects in the developmental elimination of axons that fail to participate in an active neuronal circuit by retraction, degeneration, shedding or other mechanism" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Sema3atm1Mcf/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ngfrtm1Jae/Ngfr+
Genetic Background: B6.129S4-Ngfrtm1Jae

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction / complex
 ENSMUSG00000037643 Prkci / Q62074 / protein kinase C, iota / P41743*  / reaction / complex
 ENSMUSG00000049556 Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*  / complex / reaction
 ENSMUSG00000025132 Q99PT1 / Arhgdia / Rho GDP-dissociation inhibitor 1 / P52565* / Rho GDP dissociation inhibitor alpha*  / reaction / complex
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / complex / reaction
 ENSMUSG00000043811 Rtn4r / Q99PI8 / Reticulon-4 receptor / Q9BZR6*  / reaction / complex
 ENSMUSG00000028549 Q9CQ82 / Itgb3bp / integrin beta 3 binding protein (beta3-endonexin) / Q13352* / integrin subunit beta 3 binding protein*  / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex
 ENSMUSG00000003458 Ncstn / P57716 / Nicastrin / Q92542*  / reaction
 ENSMUSG00000015750 Aph1a / Q8BVF7 / Gamma-secretase subunit APH-1A / Q96BI3* / aph-1 homolog A, gamma-secretase subunit*  / reaction
 ENSMUSG00000010609 Psen2 / presenilin 2 / P49810*  / reaction
 ENSMUSG00000015837 Q64337 / Sqstm1 / Sequestosome-1 / Q13501*  / reaction / complex
 ENSMUSG00000032375 Aph1b / Q8C7N7 / Gamma-secretase subunit APH-1B / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*  / reaction
 ENSMUSG00000019969 Psen1 / P49769 / presenilin 1 / P49768*  / reaction
 ENSMUSG00000036835 Psenen / Q9CQR7 / Gamma-secretase subunit PEN-2 / Q9NZ42* / AD000671.1* / presenilin enhancer gamma-secretase subunit*  / reaction
 ENSMUSG00000036634 Mag / P20917 / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA. / P20916* / myelin associated glycoprotein*  / reaction / complex
 ENSMUSG00000046432 Bex3 / Q9WTZ9 / Protein BEX3 / Q00994* / brain expressed X-linked 3*  / complex / reaction
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / complex / reaction
 ENSMUSG00000053040 Aph1c / Q9DCZ9 / Putative gamma-secretase subunit APH-1C / APH1B* / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*  / reaction
 ENSMUSG00000020458 Rtn4 / Q99P72 / reticulon 4 / Q9NQC3*  / reaction / complex
 ENSMUSG00000052593 Adam17 / Q9Z0F8 / Disintegrin and metalloproteinase domain-containing protein 17 / P78536* / ADAM metallopeptidase domain 17*  / reaction
 ENSMUSG00000049612 Omg / oligodendrocyte myelin glycoprotein / P23515*  / reaction / complex






 

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