Manteia

ENSMUSG00000036835

Mus musculus

Features

Gene ID:	ENSMUSG00000036835

Biological name :	Psenen

Synonyms :	Gamma-secretase subunit PEN-2 / Psenen / Q9CQR7

Possible biological names infered from orthology :	AD000671.1 / presenilin enhancer gamma-secretase subunit / Q9NZ42

Species:	Mus musculus

Chr. number:	7
Strand:	-1
Band:	B1
Gene start:	30561863
Gene end:	30563627

Corresponding Affymetrix probe sets:	10512125 (MoGene1.0st) 10562000 (MoGene1.0st) 10339165 (MoGene1.0st) 10340558 (MoGene1.0st) 10340654 (MoGene1.0st) 10342896 (MoGene1.0st) 10343271 (MoGene1.0st) 1415679_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000146469 Ensembl peptide - ENSMUSP00000147160 Ensembl peptide - ENSMUSP00000146675 Ensembl peptide - ENSMUSP00000146499 Ensembl peptide - ENSMUSP00000044682 NCBI entrez gene - 66340 See in Manteia. MGI - MGI:1913590 RefSeq - NM_025498 RefSeq Peptide - NP_079774 swissprot - A0A140LHQ1 swissprot - A0A140LHM2 swissprot - A0A140LJC5 swissprot - Q9CQR7 Ensembl - ENSMUSG00000036835

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR019379	Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006509	membrane protein ectodomain proteolysis	ISS
biological_process	GO:0007219	Notch signaling pathway	IEA
biological_process	GO:0007220	Notch receptor processing	IMP
biological_process	GO:0016485	protein processing	ISS
biological_process	GO:0034205	amyloid-beta formation	ISO
biological_process	GO:0042982	amyloid precursor protein metabolic process	ISS
biological_process	GO:0043085	positive regulation of catalytic activity	ISS
cellular_component	GO:0005783	endoplasmic reticulum	ISS
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0005794	Golgi apparatus	ISS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	ISS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0032580	Golgi cisterna membrane	IEA
cellular_component	GO:0070765	gamma-secretase complex	IBA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Nuclear signaling by ERBB4

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Slc12a6^{Gt(OST458419)Lex}/Slc12a6^{Gt(OST458419)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000003458	Ncstn / P57716 / Nicastrin / Q92542*	/ complex
ENSMUSG00000015750	Aph1a / Q8BVF7 / Gamma-secretase subunit APH-1A / Q96BI3* / aph-1 homolog A, gamma-secretase subunit*	/ complex
ENSMUSG00000032375	Aph1b / Q8C7N7 / Gamma-secretase subunit APH-1B / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*	/ complex
ENSMUSG00000019969	Psen1 / P49769 / presenilin 1 / P49768*	/ complex
ENSMUSG00000027164	Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*	/ reaction
ENSMUSG00000028549	Q9CQ82 / Itgb3bp / integrin beta 3 binding protein (beta3-endonexin) / Q13352* / integrin subunit beta 3 binding protein*	/ reaction
ENSMUSG00000026923	Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*	/ reaction
ENSMUSG00000010609	Psen2 / presenilin 2 / P49810*	/ complex
ENSMUSG00000027859	Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*	/ reaction
ENSMUSG00000000120	Ngfr / nerve growth factor receptor / P08138*	/ reaction
ENSMUSG00000062209	Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*	/ reaction
ENSMUSG00000053040	Aph1c / Q9DCZ9 / Putative gamma-secretase subunit APH-1C / APH1B* / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr