ENSDARG00000068698


Danio rerio

Features
Gene ID: ENSDARG00000068698
  
Biological name :psenen
  
Synonyms : presenilin enhancer gamma secretase subunit / psenen / Q8JHF0
  
Possible biological names infered from orthology : AD000671.1 / Gamma-secretase subunit PEN-2 / Q9CQR7 / Q9NZ42
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 37545855
Gene end: 37550338
  
Corresponding Affymetrix probe sets: Dr.6334.1.S1_at (Zebrafish Array)   NM_205576_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000090230
Ensembl peptide - ENSDARP00000153835
NCBI entrez gene - 402810     See in Manteia.
RefSeq - NM_205576
RefSeq Peptide - NP_991139
swissprot - Q8JHF0
ZFIN ID - ZDB-GENE-040218-1
Ensembl - ENSDARG00000068698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AD000671.1ENSG00000188223Homo sapiens
 PSENENENSG00000205155Homo sapiens
 PsenenENSMUSG00000036835Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019379  Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007220 Notch receptor processing IBA
 biological_processGO:0034205 amyloid-beta formation ISS
 biological_processGO:0042982 amyloid precursor protein metabolic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0097324 melanocyte migration IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0070765 gamma-secretase complex ISS


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain lacks parts or has fewer parts of type ventricular system , abnormal
brain primary motor neuron spatial pattern , abnormal
brain primary motor neuron decreased amount , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary absent , abnormal
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 ZFA:0000075 spinal cord spinal cord has fewer parts of type primary motor neuron , abnormal
spinal cord primary motor neuron spatial pattern , abnormal
spinal cord primary motor neuron decreased amount , abnormal
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 ZFA:0000155 somite somite shape , abnormal
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 ZFA:0001058 caudal fin caudal fin increased pigmentation , abnormal
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 ZFA:0001071 presumptive neural retina presumptive neural retina molecular quality , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head apoptotic process increased occurrence , abnormal
head cell death increased occurrence , abnormal
head decreased pigmentation , abnormal
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 ZFA:0001115 trunk trunk apoptotic process increased occurrence , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
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 ZFA:0001462 somite border somite border amorphous , abnormal
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 ZFA:0009090 pigment cell pigment cell morphology , abnormal
pigment cell decreased amount , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron decreased amount , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron irregular spatial pattern , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / reaction
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / reaction
 ENSDARG00000004870 psen1 / presenilin 1 / P49768* / P49769*  / complex
 ENSDARG00000015540 psen2 / Q90ZE4 / presenilin 2 / P49810*  / complex
 ENSDARG00000005612 aph1b / Q8JHE9 / APH1B gamma secretase subunit / Aph1c* / Q9DCZ9* / Q8C7N7* / Q8WW43* / Gamma-secretase subunit APH-1B * / Putative gamma-secretase subunit APH-1C * / aph-1 homolog B, gamma...  / complex






 

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