ENSDARG00000015540


Danio rerio

Features
Gene ID: ENSDARG00000015540
  
Biological name :psen2
  
Synonyms : presenilin 2 / psen2 / Q90ZE4
  
Possible biological names infered from orthology : P49810
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 51048975
Gene end: 51062405
  
Corresponding Affymetrix probe sets: Dr.8171.1.S1_at (Zebrafish Array)   NM_131514_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000011791
NCBI entrez gene - 58026     See in Manteia.
RefSeq - NM_131514
RefSeq Peptide - NP_571589
swissprot - Q90ZE4
ZFIN ID - ZDB-GENE-000330-9
Ensembl - ENSDARG00000015540
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSEN2ENSGALG00000009073Gallus gallus
 PSEN2ENSG00000143801Homo sapiens
 Psen2ENSMUSG00000010609Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
psen1 / presenilin 1 / P49768* / P49769*ENSDARG0000000487063


Protein motifs (from Interpro)
Interpro ID Name
 IPR001108  Peptidase A22A, presenilin
 IPR001493  Peptidase A22A, presenilin 2
 IPR006639  Presenilin/signal peptide peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IBA
 biological_processGO:0006816 calcium ion transport IBA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007220 Notch receptor processing IBA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0034205 amyloid-beta formation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0061053 somite development IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005743 mitochondrial inner membrane IBA
 cellular_componentGO:0005765 lysosomal membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005938 cell cortex IBA
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030018 Z disc IBA
 cellular_componentGO:0030424 axon IBA
 cellular_componentGO:0030426 growth cone IBA
 cellular_componentGO:0031594 neuromuscular junction IBA
 cellular_componentGO:0035253 ciliary rootlet IBA
 cellular_componentGO:0043025 neuronal cell body IBA
 cellular_componentGO:0043198 dendritic shaft IBA
 cellular_componentGO:0045121 membrane raft IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IBA
 molecular_functionGO:0004175 endopeptidase activity IBA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
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 ZFA:0000029 hindbrain hindbrain hydrocephalic , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
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 ZFA:0000128 midbrain midbrain hydrocephalic , abnormal
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 ZFA:0000159 tectal ventricle tectal ventricle increased size , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001115 trunk trunk melanocyte decreased amount , abnormal
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 ZFA:0001117 post-vent region post-vent region melanocyte decreased amount , abnormal
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 ZFA:0005178 DoLA DoLA increased amount , abnormal
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 ZFA:0009091 melanocyte melanocyte spatial pattern , abnormal
melanocyte decreased amount , abnormal
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 ZFA:0009165 neural crest cell neural crest cell decreased amount , abnormal
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 ZFA:0009248 neuron neuron increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000015540 psen2 / Q90ZE4 / presenilin 2 / P49810*  / complex
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / reaction
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / reaction
 ENSDARG00000005612 aph1b / Q8JHE9 / APH1B gamma secretase subunit / Aph1c* / Q9DCZ9* / Q8C7N7* / Q8WW43* / Gamma-secretase subunit APH-1B * / Putative gamma-secretase subunit APH-1C * / aph-1 homolog B, gamma...  / complex
 ENSDARG00000068698 psenen / Q8JHF0 / presenilin enhancer gamma secretase subunit / Q9NZ42* / Q9CQR7* / AD000671.1* / Gamma-secretase subunit PEN-2 *  / complex






 

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