ENSGALG00000009073


Gallus gallus

Features
Gene ID: ENSGALG00000009073
  
Biological name :PSEN2
  
Synonyms : presenilin 2 / PSEN2
  
Possible biological names infered from orthology : P49810
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 12487853
Gene end: 12504334
  
Corresponding Affymetrix probe sets: Gga.2719.1.S2_at (Chicken Array)   Gga.2719.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014749
Ensembl peptide - ENSGALP00000058473
Ensembl peptide - ENSGALP00000045395
NCBI entrez gene - 374188     See in Manteia.
RefSeq - NM_204302
RefSeq - XM_015283432
RefSeq - XM_015283433
RefSeq Peptide - NP_989633
swissprot - A0A1D5PZQ7
swissprot - A0A1D5NYD7
swissprot - F1NGP7
Ensembl - ENSGALG00000009073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psen2ENSDARG00000015540Danio rerio
 PSEN2ENSG00000143801Homo sapiens
 Psen2ENSMUSG00000010609Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PSEN1 / Q4JIM4 / Presenilin-1 Presenilin-1 NTF subunit Presenilin-1 CTF subunit / P49768* / P49769* / presenilin 1*ENSGALG0000000932063


Protein motifs (from Interpro)
Interpro ID Name
 IPR001108  Peptidase A22A, presenilin
 IPR001493  Peptidase A22A, presenilin 2
 IPR006639  Presenilin/signal peptide peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042987 amyloid precursor protein catabolic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042500 aspartic endopeptidase activity, intramembrane cleaving IEA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000009073 PSEN2 / presenilin 2 / P49810*  / complex
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / reaction
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / reaction
 ENSGALG00000045163 APH1A / aph-1 homolog A, gamma-secretase subunit / Q8BVF7* / Q96BI3* / Gamma-secretase subunit APH-1A *  / complex






 

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