ENSGALG00000009320


Gallus gallus

Features
Gene ID: ENSGALG00000009320
  
Biological name :PSEN1
  
Synonyms : Presenilin-1 Presenilin-1 NTF subunit Presenilin-1 CTF subunit / PSEN1 / Q4JIM4
  
Possible biological names infered from orthology : P49768 / P49769 / presenilin 1
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 26365084
Gene end: 26386235
  
Corresponding Affymetrix probe sets: Gga.14507.1.S1_at (Chicken Array)   Gga.3864.1.S1_at (Chicken Array)   Gga.3864.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000031992
NCBI entrez gene - 373977     See in Manteia.
RefSeq - XM_015286913
RefSeq - NM_204163
RefSeq - XM_015286914
RefSeq Peptide - NP_989494
swissprot - Q4JIM4
Ensembl - ENSGALG00000009320
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psen1ENSDARG00000004870Danio rerio
 PSEN1ENSG00000080815Homo sapiens
 Psen1ENSMUSG00000019969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PSEN2 / presenilin 2 / P49810*ENSGALG0000000907361


Protein motifs (from Interpro)
Interpro ID Name
 IPR001108  Peptidase A22A, presenilin
 IPR002031  Peptidase A22A, presenilin 1
 IPR006639  Presenilin/signal peptide peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001708 cell fate specification IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0002265 astrocyte activation involved in immune response IEA
 biological_processGO:0002286 T cell activation involved in immune response IEA
 biological_processGO:0002573 myeloid leukocyte differentiation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0006816 calcium ion transport IBA
 biological_processGO:0006839 mitochondrial transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0007176 regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007220 Notch receptor processing IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0015813 L-glutamate transmembrane transport IEA
 biological_processGO:0015871 choline transport IEA
 biological_processGO:0016080 synaptic vesicle targeting IEA
 biological_processGO:0016485 protein processing ISS
 biological_processGO:0021795 cerebral cortex cell migration IEA
 biological_processGO:0021870 Cajal-Retzius cell differentiation IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034205 amyloid-beta formation IEA
 biological_processGO:0035282 segmentation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040011 locomotion IEA
 biological_processGO:0042325 regulation of phosphorylation IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042982 amyloid precursor protein metabolic process IEA
 biological_processGO:0042987 amyloid precursor protein catabolic process IBA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043589 skin morphogenesis IEA
 biological_processGO:0044267 cellular protein metabolic process IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048143 astrocyte activation IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0050435 amyloid-beta metabolic process IEA
 biological_processGO:0050673 epithelial cell proliferation IEA
 biological_processGO:0050771 negative regulation of axonogenesis IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0050820 positive regulation of coagulation IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0051563 smooth endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0051604 protein maturation IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IBA
 biological_processGO:0060075 regulation of resting membrane potential IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0090647 modulation of age-related behavioral decline IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1904797 negative regulation of core promoter binding IEA
 biological_processGO:1905908 positive regulation of amyloid fibril formation IEA
 biological_processGO:1990535 neuron projection maintenance IEA
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process IEA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IBA
 cellular_componentGO:0005765 lysosomal membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0030018 Z disc IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031594 neuromuscular junction IBA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035253 ciliary rootlet IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0043227 membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IBA
 cellular_componentGO:0070765 gamma-secretase complex IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042500 aspartic endopeptidase activity, intramembrane cleaving ISS
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000009320 PSEN1 / Q4JIM4 / Presenilin-1 Presenilin-1 NTF subunit Presenilin-1 CTF subunit / P49768* / P49769* / presenilin 1*  / complex
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / reaction
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / reaction
 ENSGALG00000045163 APH1A / aph-1 homolog A, gamma-secretase subunit / Q8BVF7* / Q96BI3* / Gamma-secretase subunit APH-1A *  / complex






 

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