ENSGALG00000045163


Gallus gallus

Features
Gene ID: ENSGALG00000045163
  
Biological name :APH1A
  
Synonyms : APH1A / aph-1 homolog A, gamma-secretase subunit
  
Possible biological names infered from orthology : Gamma-secretase subunit APH-1A / Q8BVF7 / Q96BI3
  
Species: Gallus gallus
  
Chr. number: 25
Strand: -1
Band:
Gene start: 2391546
Gene end: 2394670
  
Corresponding Affymetrix probe sets: Gga.15996.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000059742
NCBI entrez gene - 431243     See in Manteia.
RefSeq - XM_015298667
RefSeq - XM_428797
swissprot - A0A1L1RLV1
Ensembl - ENSGALG00000045163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APH1AENSG00000117362Homo sapiens
 Aph1aENSMUSG00000015750Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000000257857


Protein motifs (from Interpro)
Interpro ID Name
 IPR009294  Gamma-secretase subunit Aph-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0007220 Notch receptor processing IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis IEA
 biological_processGO:0034205 amyloid-beta formation IEA
 biological_processGO:0042982 amyloid precursor protein metabolic process IEA
 biological_processGO:0042987 amyloid precursor protein catabolic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070765 gamma-secretase complex IEA
 molecular_functionGO:0004175 endopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000009320 PSEN1 / Q4JIM4 / Presenilin-1 Presenilin-1 NTF subunit Presenilin-1 CTF subunit / P49768* / P49769* / presenilin 1*  / complex
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / reaction
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / reaction
 ENSGALG00000009073 PSEN2 / presenilin 2 / P49810*  / complex






 

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