| MP:0000074 | abnormal neurocranium morphology | "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0000079 | abnormal basioccipital bone morphology | "malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0000136 | abnormal microglial cell morphology | "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688] |
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Allelic Composition: Cx3cl1tm1Lira/Cx3cl1tm1Lira
Genetic Background: involves: C57BL/6
|
| MP:0000137 | abnormal vertebrae morphology | "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000140 | absent pedicles | "loss of part of the posteriorlateral vertebral arch of a thoracic vertebrae" [J:62022, J:62023] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: Not Specified
|
| MP:0000141 | abnormal vertebral body morphology | "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: Not Specified
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: Not Specified
|
| MP:0000154 | rib fusion | "appearance of one or more ribs as a single structure" [J:62022, J:62023] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0000157 | abnormal sternum morphology | "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000259 | abnormal vascular development | "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0000260 | abnormal angiogenesis | "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0000269 | abnormal looping morphogenesis | "atypical bending of the primitive heart tube during early development" [J:27443] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw,Psen2tm1Ber/Psen2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
|
| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae
|
| MP:0000292 | distended pericardial sacs | "stretched outer parietal layer of the pericardium" [J:25248] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)
|
| MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
Show
Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
|
| MP:0000417 | short hair | "reduced average length of the hairs" [J:64948] |
Show
Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
|
| MP:0000418 | patchy hair | "uneven spots of hair growth on the body" [J:26975] |
Show
Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
|
| MP:0000556 | abnormal hindlimb morphology | "malformation of the entire posterior extremities" [MGI:tc] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0000585 | kinked tail | "a sharp bend or zig-zag in the tail" [J:61295] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Psen1tm4.1Shn/Psen1tm4.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Psen1tm5.1Shn/Psen1tm5.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
|
| MP:0000592 | short tail | "reduced length of tail compared to control " [J:55583] |
Show
Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Psen1tm1.1Tcs/Psen1tm1.1Tcs
Genetic Background: involves: C57BL/6J
Allelic Composition: Psen1tm1Shn/Psen1tm1.1Tcs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Psen1tm1Mpm/Psen1tm1Shn
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Psen1tm4.1Shn/Psen1tm4.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Psen1tm5.1Shn/Psen1tm5.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000780 | abnormal corpus callosum morphology | "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
Show
Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
Show
Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm2Shn/Psen1tm4.1Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA
|
| MP:0000790 | abnormal stratification in cerebral cortex | "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
|
| MP:0000792 | abnormal cortical marginal zone morphology | |
Show
Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0000798 | abnormal frontal lobe morphology | "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0000801 | abnormal temporal lobe morphology | "malformation or absence of the lower lateral part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
Show
Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0000808 | abnormal hippocampus development | "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0000812 | abnormal dentate gyrus morphology | "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0000826 | abnormal third ventricle morphology | "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0000830 | abnormal diencephalon morphology | "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0000832 | abnormal thalamus morphology | "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
Show
Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000936 | small telencephalic vesicles | "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0000955 | abnormal spinal cord morphology | "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000963 | fused dorsal root ganglia | "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001126 | abnormal ovary morphology | "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
Show
Allelic Composition: Bap1tm1.1Geno/Bap1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
|
| MP:0001191 | abnormal skin condition | "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
| MP:0001192 | scaly skin | "skin covered with shedding scales or flakes" [J:65146] |
Show
Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
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| MP:0001194 | dermatitis | "inflammation of the skin" [J:65146] |
Show
Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0001200 | thick skin | "greater depth of skin " [J:47225] |
Show
Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
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| MP:0001209 | spontaneous skin ulceration | "unpredictable appearance of skin lesions, usually with inflammation" [J:65302] |
Show
Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
Show
Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0001216 | abnormal epidermal layer morphology | "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
| MP:0001219 | thickened epidermis | "increase in the width of the epidermal cell layer in the skin" [J:65146] |
Show
Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
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| MP:0001222 | epidermal hyperplasia | "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
Show
Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0001242 | hyperkeratosis | "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001313 | increased incidence of corneal inflammation | "greater than average and persistent occurrence of corneal irritation" [J:4606] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001363 | increased anxiety-related response | "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060] |
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Allelic Composition: Apptm3.1Zhe/Apptm3.1Zhe,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
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| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
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| MP:0001458 | abnormal object recognition memory | "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA
Allelic Composition: Psen1tm2Shn/Psen1tm2.1Shn,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA
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| MP:0001469 | abnormal contextual conditioning | "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)
Allelic Composition: Psen1tm1Mpm/Psen1tm1Pcw
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001473 | reduced long term potentiation | "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3] |
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Allelic Composition: Psen1tm4.1Shn/Psen1+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2
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| MP:0001488 | increased startle reflex | "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Relbshep/Relbshep
Genetic Background: A;C-Relbshep/GrsrJ
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| MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J
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| MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
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| MP:0001648 | abnormal apoptosis | "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248] |
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0001688 | abnormal somite development | "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
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| MP:0001690 | failure of somite differentiation | "disorganized or absent somite tissue or somite pattern in development" [J:25248] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw,Psen2tm1Ber/Psen2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
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| MP:0001691 | abnormal somite shape | "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
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| MP:0001718 | abnormal yolk sac | "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001745 | increased circulating corticosterone level | "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931] |
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
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| MP:0001750 | increased circulating follicle stimulating hormone level | "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bap1tm1.1Geno/Bap1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J
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| MP:0001786 | skin edema | "accumulation of an excessive amount of fluid in the skin" [J:65039] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001844 | autoimmune response | "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001859 | kidney inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001900 | impaired synaptic plasticity | "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Psen1tm4.1Shn/Psen1+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1.1Tcs/Psen1tm1.1Tcs
Genetic Background: involves: C57BL/6J
Allelic Composition: Psen1tm1Shn/Psen1tm1.1Tcs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Psen1tm1Mpm/Psen1tm1Shn
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J
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| MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0001916 | intracerebral hemorrhage | "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001917 | intraventricular hemorrhage | "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Bap1tm1.1Geno/Bap1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0002063 | abnormal learning/memory/conditioning | "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002073 | abnormal hair growth | "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0002089 | abnormal postnatal growth/weight/body size | "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002109 | abnormal limb morphology | "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J
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| MP:0002111 | abnormal tail morphology | "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J
Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd
Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1+
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd
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| MP:0002114 | abnormal axial skeleton morphology | "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm1Psgh/Psen1tm1Psgh
Genetic Background: Not Specified
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0002128 | abnormal blood circulation | "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw,Psen2tm1Ber/Psen2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
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| MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Psen1tm1Tak/Psen1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
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| MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apptm1.1Cep/App+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0002188 | small heart | "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw,Psen2tm1Ber/Psen2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
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| MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd
Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1+
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd
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| MP:0002207 | abnormal long term potentiation | "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-APPLon)2Vln/0,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
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| MP:0002229 | CNS neurodegeneration | "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Psen1tm2Shn/Psen1tm4.1Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA
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| MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0002461 | increased circulating immunoglobulin concentration | "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002499 | chronic inflammation | "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0002607 | decreased basophil count | "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database] |
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1+
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd
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| MP:0002621 | delayed neural tube closure | "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw,Psen2tm1Ber/Psen2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
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| MP:0002743 | glomerulonephritis | "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0002823 | abnormal rib development | "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0002824 | abnormal chorioallantoic fusion | "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
|
| MP:0002882 | abnormal neuron | "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0002916 | increased synaptic depression | "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Psen1tm4.1Shn/Psen1+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2
|
| MP:0002920 | reduced paired-pulse facilitation | "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Psen1tm4.1Shn/Psen1+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2
|
| MP:0002962 | increased protein excretion | "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0003051 | curly tail | "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0003052 | omphalocele | "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: Not Specified
|
| MP:0003214 | neurofibrillary tangles | "dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Tak/Psen1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0003224 | neuron degeneration | "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
| MP:0003229 | abnormal vitelline vasculature | "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0003232 | abnormal forebrain development | "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0003329 | amyloid beta deposits | |
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Allelic Composition: Apptm1.1Cep/App+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Psen1tm1Vln/Psen1tm1Vln,Tg(Thy1-cre)1Vln/0
Genetic Background: involves: FVB/N
Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)
Allelic Composition: Apptm1.1Cep/Apptm1.1Cep,Psen1tm1Dgf/Psen1tm1Dgf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Psen1tm1Zhe/Psen1tm1Zhe,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA
Allelic Composition: Psen1tm2Shn/Psen1tm2.1Shn,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA
Allelic Composition: Apptm3.1Zhe/Apptm3.1Zhe,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
Allelic Composition: Psen1tm1.1Tcs/Psen1tm1.1Tcs,Tg(APPSWE)2576Kha/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL
Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
Allelic Composition: Psen1tm4.1Shn/Psen1+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2
|
| MP:0003345 | decreased number of ribs | "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Psen1tm1.1Tcs/Psen1tm1.1Tcs,Tg(APPSWE)2576Kha/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL
Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Psen1tm2Shn/Psen1tm4.1Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA
|
| MP:0003385 | abnormal body wall | "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0003400 | kinked neural tube | "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Allelic Composition: Psen1tm1Bdes/Psen1tm1Bdes,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0003413 | hair follicle degeneration | "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517] |
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Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
|
| MP:0003414 | epidermal cyst | "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0003424 | premature neuronal precursor differentiation | "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391] |
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Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
|
| MP:0003459 | increased fear-related response | "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University] |
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
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| MP:0003658 | abnormal capillaries | "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003691 | abnormal microglial cell function | "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
| MP:0003843 | abnormal sagittal suture morphology | "malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0003864 | abnormal midbrain development | "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
|
| MP:0003871 | abnormal myelin sheath morphology | "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0003944 | abnormal T cell subpopulation ratio | "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Bdes/Psen1tm1Bdes,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0004073 | caudal body truncation | "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Bdes/Psen1tm1Bdes,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0004076 | abnormal vitelline vascular remodelling | "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Bdes/Psen1tm1Bdes,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0004174 | abnormal spine curvature | "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Psen1tm1.1Tcs/Psen1tm1.1Tcs
Genetic Background: involves: C57BL/6J
Allelic Composition: Psen1tm1Shn/Psen1tm1.1Tcs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Psen1tm1Mpm/Psen1tm1Shn
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
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| MP:0004201 | fetal growth retardation | "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
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| MP:0004250 | tau protein deposits | "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
Allelic Composition: Psen1tm1Tak/Psen1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0004251 | failure of looping morphogenesis | "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
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| MP:0004277 | abnormal lateral ganglionic eminence morphology | "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm4.1Shn/Psen1tm4.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Psen1tm5.1Shn/Psen1tm5.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0004321 | short sternum | "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0004546 | esophagus hyperplasia | "overdevelopment or increased size, usually due an increased number of cells of the esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
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| MP:0004599 | abnormal vertebral arch morphology | "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp2tm4Ysa/Mesp2tm4Ysa,Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Mesp2tm5(Notch1)Ysa/Mesp2tm5(Notch1)Ysa,Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6 * CBA
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| MP:0004605 | abnormal vertebral lamina morphology | "any structural anomaly of two broad plates directed dorsomedially from the pedicles; these fuse at the dorsal midline, and complete the dorsal wall of the vertebral foramen
" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: Not Specified
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004609 | vertebral fusion | "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0004620 | cervical vertebral fusion | "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0004621 | lumbar vertebral fusion | "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0004622 | sacral vertebral fusion | "the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0004624 | abnormal thoracic cage | "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: Not Specified
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| MP:0004703 | abnormal vertebral column | "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: Not Specified
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004771 | increased anti-single stranded DNA antibody level | "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cul4atm1.1Pra/Cul4atm1.1Pra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6NTac * DBA
|
| MP:0004947 | skin inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0004948 | abnormal neuronal precursor proliferation | "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
|
| MP:0004950 | abnormal brain vasculature | "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0004980 | increased neuronal precursor cell number | "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
|
| MP:0004981 | decreased neuronal precursor cell number | "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0005161 | hematuria | "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0005223 | abnormal anterior-posterior polarity of the somites | "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body
" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325] |
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Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: Not Specified
|
| MP:0005225 | abnormal vertebrae development | "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0005350 | increased susceptibility to autoimmune disorders | "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0005388 | respiratory system phenotype | |
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd
|
| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0005412 | vascular stenosis | "narrowing or constriction of a blood vessel" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0005421 | loose skin | "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0005590 | increased vasodilation | "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0005623 | abnormal meninges | "anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, smb:Susan M. Bello , Mouse Genome Informatics Curator, J:48079] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0005650 | abnormal limb bud morphology | "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460] |
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd
Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1+
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd
|
| MP:0006000 | abnormal corneal epithelium | "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0006009 | abnormal neuronal migration | "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
|
| MP:0006029 | abnormal sclerotome | "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: Not Specified
|
| MP:0006054 | spinal hemorrhage | "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0006055 | abnormal vascular endothelial cell morphology | "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0006108 | abnormal hindbrain development | "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0006279 | abnormal limb development | "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1.1Tcs/Psen1tm1.1Tcs
Genetic Background: involves: C57BL/6J
Allelic Composition: Psen1tm1Shn/Psen1tm1.1Tcs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Psen1tm1Mpm/Psen1tm1Shn
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
|
| MP:0006344 | small second branchial arch | "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw,Psen2tm1Ber/Psen2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
|
| MP:0008029 | abnormal paraxial mesoderm | "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
|
| MP:0008031 | decreased Cajal-Retzius cell number | "reduced number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0008149 | abnormal rib-vertebral column attachment | "any anomaly in the in the normal joining of the ribs to the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0008235 | increased susceptibility to neuronal excitotoxicity | "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0008284 | abnormal hippocampus pyramidal cell layer | |
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)
|
| MP:0008286 | abnormal hippocampus molecular cell layer | |
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0008414 | abnormal spatial reference memory | "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm4.1Shn/Psen1+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2
|
| MP:0008415 | abnormal neurite morphology | "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572] |
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0008428 | abnormal spatial working memory | "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA
|
| MP:0008431 | abnormal short-term spatial reference memory | "anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encouter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1.1Tcs/Psen1tm1.1Tcs,Tg(APPSWE)2576Kha/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL
|
| MP:0008432 | abnormal long-term spatial reference memory | "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA
Allelic Composition: Psen1tm2Shn/Psen1tm2.1Shn,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA
|
| MP:0008441 | thin cortical plate | "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0008458 | abnormal cortical ventricular zone morphology | "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm4.1Shn/Psen1tm4.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Psen1tm5.1Shn/Psen1tm5.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
|
| MP:0008530 | abnormal rostral-caudal patterning of the somites | "anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0008535 | enlarged lateral ventricles | "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0008536 | enlarged third ventricle | "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt,Psen2tm1Ber/Psen2tm1Ber,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0008547 | abnormal neocortex morphology | "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420] |
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Allelic Composition: Psen1tm2Shn/Psen1tm4.1Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA
|
| MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Psen1tm2Shn/Psen1tm4.1Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA
|
| MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
Allelic Composition: Psen1tm2Shn/Psen1tm4.1Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Camk2a-cre)1Shn/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA
|
| MP:0009453 | enhanced contextual conditioning | "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
|
| MP:0009937 | abnormal neuron differentiation | "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
Allelic Composition: Psen1tm1Mpm/Psen1tm1Pcw
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
|
| MP:0009938 | abnormal hippocampus granule cell morphology | "any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0010052 | increased grip strength | "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0010138 | arteritis | "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Bdes/Psen1+,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae
|
| MP:0010459 | supravalvar pulmonary trunk stenosis | "diffuse constriction or narrowing of the pulmonary trunk distal to the pulmonary valve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae
|
| MP:0010685 | abnormal hair follicle inner root sheath morphology | "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055] |
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Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
|
| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Psen1tm4.1Shn/Psen1tm4.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Psen1tm5.1Shn/Psen1tm5.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6
Allelic Composition: Psen1tm1Bdes/Psen1tm1Bdes,Psen2tm1Bdes/Psen2tm1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1.1Tcs
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Psen1tm1Pcw/Psen1+,Psen2tm1Ber/Psen2tm1Ber
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Allelic Composition: Psen1tm1Pcw/Psen1tm1Pcw,Psen2tm1Ber/Psen2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Psen1tm1.1Tcs/Psen1tm1.1Tcs
Genetic Background: involves: C57BL/6J
Allelic Composition: Psen1tm1Mpm/Psen1tm1Shn
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J
Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0012173 | short rostral-caudal axis | "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Psen1tm4.1Shn/Psen1tm4.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Psen1tm5.1Shn/Psen1tm5.1Shn
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0013380 | absent sebocyte | "failure of formation or loss of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation" [MGI:Anna, PMID:19944183] |
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Allelic Composition: Psen1tm2Shn/Psen1tm2Shn,Psen2tm1Haa/Psen2tm1Haa,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae
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| MP:0020329 | decreased capillary density | "reduction in the number of capillaries in a given cross-sectional area of a tissue" [ORCID: orcid.org/0000-0003-4606-0597, PMID:20944627] |
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Allelic Composition: Psen1tm1Hko/Psen1tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0030286 | occipital bone hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the bone at the lower, posterior part of the skull" [MGI:anna] |
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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