ENSMUSG00000026923


Mus musculus

Features
Gene ID: ENSMUSG00000026923
  
Biological name :Notch1
  
Synonyms : Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / Notch1 / Q01705
  
Possible biological names infered from orthology : P46531
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 26457903
Gene end: 26516663
  
Corresponding Affymetrix probe sets: 10481056 (MoGene1.0st)   1418633_at (Mouse Genome 430 2.0 Array)   1418634_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115258
Ensembl peptide - ENSMUSP00000028288
NCBI entrez gene - 18128     See in Manteia.
MGI - MGI:97363
RefSeq - NM_008714
RefSeq Peptide - NP_032740
swissprot - A2AIX5
swissprot - Q01705
Ensembl - ENSMUSG00000026923
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 notch1aENSDARG00000103554Danio rerio
 notch1bENSDARG00000052094Danio rerio
 NOTCH1ENSGALG00000002375Gallus gallus
 NOTCH1ENSG00000148400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Notch2 / Q04721*ENSMUSG0000002787853
Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*ENSMUSG0000003814647
Notch4 / Q99466*ENSMUSG0000001546833
Sned1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSMUSG0000004779315
Jag2 / Q9QYE5 / Protein jagged-2 / Q9Y219* / jagged 2*ENSMUSG0000000279914
Jag1 / Q9QXX0 / Protein jagged-1 / P78504* / jagged 1*ENSMUSG0000002727613
Dll1 / Q61483 / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / O00548* / delta like canonical Notch ligand 1*ENSMUSG000000147738
Dll4 / Q9JI71 / Delta-like protein 4 / Q9NR61* / delta like canonical Notch ligand 4*ENSMUSG000000273148


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR008297  Notch
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022362  Neurogenic locus Notch 1
 IPR024600  Domain of unknown function DUF3454, notch
 IPR035993  Notch-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001947 heart looping IGI
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002051 osteoblast fate commitment NAS
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IGI
 biological_processGO:0003157 endocardium development IMP
 biological_processGO:0003160 endocardium morphogenesis IMP
 biological_processGO:0003162 atrioventricular node development IMP
 biological_processGO:0003169 coronary vein morphogenesis IMP
 biological_processGO:0003180 aortic valve morphogenesis IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0003184 pulmonary valve morphogenesis IEA
 biological_processGO:0003192 mitral valve formation IEA
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:0003203 endocardial cushion morphogenesis IMP
 biological_processGO:0003207 cardiac chamber formation IMP
 biological_processGO:0003208 cardiac ventricle morphogenesis IMP
 biological_processGO:0003209 cardiac atrium morphogenesis IMP
 biological_processGO:0003213 cardiac right atrium morphogenesis IMP
 biological_processGO:0003214 cardiac left ventricle morphogenesis IMP
 biological_processGO:0003219 cardiac right ventricle formation IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0003241 growth involved in heart morphogenesis IMP
 biological_processGO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IMP
 biological_processGO:0003264 regulation of cardioblast proliferation IEA
 biological_processGO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation IMP
 biological_processGO:0003273 cell migration involved in endocardial cushion formation IMP
 biological_processGO:0003344 pericardium morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006959 humoral immune response IGI
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007219 Notch signaling pathway ISO
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007386 compartment pattern specification IMP
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007440 foregut morphogenesis IMP
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008544 epidermis development IGI
 biological_processGO:0008593 regulation of Notch signaling pathway IGI
 biological_processGO:0009912 auditory receptor cell fate commitment IMP
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IEA
 biological_processGO:0010832 negative regulation of myotube differentiation IDA
 biological_processGO:0014031 mesenchymal cell development IMP
 biological_processGO:0014807 regulation of somitogenesis IMP
 biological_processGO:0021515 cell differentiation in spinal cord IEA
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0030279 negative regulation of ossification IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IDA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031960 response to corticosteroid IEA
 biological_processGO:0032495 response to muramyl dipeptide IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0035148 tube formation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IEA
 biological_processGO:0045607 regulation of inner ear auditory receptor cell differentiation IMP
 biological_processGO:0045608 negative regulation of inner ear auditory receptor cell differentiation IMP
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IGI
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045687 positive regulation of glial cell differentiation IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045955 negative regulation of calcium ion-dependent exocytosis IMP
 biological_processGO:0045967 negative regulation of growth rate IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IDA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IMP
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0048103 somatic stem cell division IGI
 biological_processGO:0048663 neuron fate commitment IGI
 biological_processGO:0048708 astrocyte differentiation IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IDA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IDA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 biological_processGO:0050678 regulation of epithelial cell proliferation IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IGI
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0050768 negative regulation of neurogenesis IDA
 biological_processGO:0050793 regulation of developmental process IEA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060038 cardiac muscle cell proliferation IMP
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060253 negative regulation of glial cell proliferation IDA
 biological_processGO:0060271 cilium assembly ISS
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IMP
 biological_processGO:0060411 cardiac septum morphogenesis IMP
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IMP
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0060740 prostate gland epithelium morphogenesis IMP
 biological_processGO:0060768 regulation of epithelial cell proliferation involved in prostate gland development IMP
 biological_processGO:0060842 arterial endothelial cell differentiation IMP
 biological_processGO:0060843 venous endothelial cell differentiation IMP
 biological_processGO:0060948 cardiac vascular smooth muscle cell development IMP
 biological_processGO:0060956 endocardial cell differentiation IMP
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis IMP
 biological_processGO:0060982 coronary artery morphogenesis IMP
 biological_processGO:0061314 Notch signaling involved in heart development IMP
 biological_processGO:0061344 regulation of cell adhesion involved in heart morphogenesis IC
 biological_processGO:0061384 heart trabecula morphogenesis IMP
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070986 left/right axis specification IGI
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0072017 distal tubule development IEP
 biological_processGO:0072044 collecting duct development IEP
 biological_processGO:0072144 glomerular mesangial cell development IEP
 biological_processGO:0072602 interleukin-4 secretion IGI
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:1901189 positive regulation of ephrin receptor signaling pathway IC
 biological_processGO:1901201 regulation of extracellular matrix assembly IMP
 biological_processGO:1902263 apoptotic process involved in embryonic digit morphogenesis IMP
 biological_processGO:1903849 positive regulation of aorta morphogenesis IMP
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 biological_processGO:2000811 negative regulation of anoikis IEA
 biological_processGO:2000974 negative regulation of pro-B cell differentiation IMP
 biological_processGO:2001027 negative regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0002193 MAML1-RBP-Jkappa- ICN1 complex IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0004857 enzyme inhibitor activity IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005112 Notch binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agpat2Gt(OST438470)Lex/Agpat2Gt(OST438470)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Notch1tm2.1Pst/Notch1tm2.1Pst
Genetic Background: B6.Cg-Notch1tm2.1Pst

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Cdh5-cre)7Mlia/0,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gusbmps/Gusbmps
Genetic Background: B6.C-H2-Kbm1/ByBir-Gusbmps/J

Allelic Composition: Notch1tm1Agt/Notch1+,Notch2tm1Frad/Notch2tm1Frad,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2+,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0000387 disorganized inner root sheath cells "disordered enveloping layer of cells of the hair follicle; comprises the cuticle of the inner roots" [J:56777]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0000388 absent inner root sheath "missing epidermally derived layer surrounding the hair follicle; innermost of two layers" [J:65047]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0000417 short hair "reduced average length of the hairs" [J:64948]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Cdh23v-bus/Cdh23v-bus
Genetic Background: KYF/MsIdr

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000648 absent sebaceous gland "missing the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Notch1tm2Pst/Notch1tm2Pst
Genetic Background: B6.Cg-Notch1tm2Pst

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Notch1tm2.1Pst/Notch1tm2.1Pst
Genetic Background: B6.Cg-Notch1tm2.1Pst

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm2.1Pst/Notch1tm2.1Pst
Genetic Background: B6.Cg-Notch1tm2.1Pst

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm2Pst/Notch1tm2.1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grm1rcw-3J/Grm1rcw-3J
Genetic Background: C57BL/6J-Grm1rcw-3J/GrsrJ

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Aestm1Grid/Aestm1Grid,Notch1tm1Grid/Notch1+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Notch1tm2Pst/Notch1tm2Pst
Genetic Background: B6.Cg-Notch1tm2Pst

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch1tm1Pst/Notch1tm1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA

Allelic Composition: Notch1tm2Pst/Notch1tm2Pst
Genetic Background: B6.Cg-Notch1tm2Pst

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1.1(cre/ERT2)Sat/Notch1+
Genetic Background: C57BL/6-Notch1tm1.1(cre/ERT2)Sat

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003044 impaired basement membrane formation "defect in the organization and/or placement of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Cd79am1Anu/Cd79am1Anu
Genetic Background: C57BL/6-Cd79am1Anu

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm6.1Rko/Notch1+,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Notch1tm2Rko/Notch1tm2Rko,Tg(SFTPC-rtTA)5Jaw/?,Tg(tetO-cre)1Jaw/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch3tm1Grid/Notch3tm1Grid
Genetic Background: Not Specified

Allelic Composition: Notch1tm1Pst/Notch1tm1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Notch1tm2.1Pst/Notch1tm2.1Pst
Genetic Background: B6.Cg-Notch1tm2.1Pst

Allelic Composition: Notch1tm2Pst/Notch1tm2.1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0004125 abnormal venule morphology "any structural anomaly in the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm1rcw-3J/Grm1rcw-3J
Genetic Background: C57BL/6J-Grm1rcw-3J/GrsrJ

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm2Pst/Notch1tm2.1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004381 abnormal hair follicle melanocyte morphology "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1+,Notch2tm1Frad/Notch2tm1Frad,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Grid/Notch1tm2Rko,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6J * Swiss Webster

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm2Gsv/Gata3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0004497 decreased supporting cell number "decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Grid/Notch1tm2Rko,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * C57BL/6J * Swiss Webster

 MP:0004712 notochord degeneration "retrogressive pathologic change of the axial fibrocellular cord in embryos around which develops the vertebral primordia (prior to normal differentiation of this tissue into the vertebral column tissues)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0004784 abnormal anterior cardinal vein morphology "any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm2Pst/Notch1tm2Pst
Genetic Background: B6.Cg-Notch1tm2Pst

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Notch1tm2Pst/Notch1tm2Pst
Genetic Background: B6.Cg-Notch1tm2Pst

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0005222 abnormal somite size "atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0005224 abnormal left-right axis symmetry of the somites "anomaly in the formation or development of the somites in relation to the left and right sides of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005544 corneal deposits "accumulation of minerals, proteins, or other anomalous substances on the cornea" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0006093 arteriovenous malformation "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129

Allelic Composition: Notch1tm5(cre/ERT2)Rko/Notch1tm5(cre/ERT2)Rko
Genetic Background: involves: C57BL/6NTac

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya1tm1Rilm/Eya1tm1Rilm,Notch1tm2Rko/Notch1tm2Rko,Tg(SFTPC-rtTA)5Jaw/?,Tg(tetO-cre)1Jaw/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm2Pst/Notch1tm2Pst
Genetic Background: B6.Cg-Notch1tm2Pst

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Cdh5-cre)7Mlia/0,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He

 MP:0008986 abnormal liver parenchyma morphology "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008987 abnormal liver lobule morphology "any structural anomaly of the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009165 abnormal endocrine pancreas morphology "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009328 delayed heart looping "late onset of the initiation and/or completion of cardiac looping" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Notch1tm1Agt/Notch1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm2Gsv/Gata3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Notch1tm1Grid/Notch1+,Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010500 myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129

 MP:0010561 absent coronary vessels "absence of the arteries and veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Notch1tm1Pst/Notch1tm1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

Allelic Composition: Notch1tm1Con/Notch1tm1Grid,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Notch1tm2.1Pst/Notch1tm2.1Pst
Genetic Background: B6.Cg-Notch1tm2.1Pst

Allelic Composition: Notch1tm2Pst/Notch1tm2.1Pst
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Notch1tm2Rko/Notch1tm4(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nek7tm1b(EUCOMM)Hmgu/Nek7tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nek7tm1b(EUCOMM)Hmgu/J

 MP:0011181 increased hematopoietic cell number "greater than expected number of cells of the hematopoietic lineage" [MGI:csmith]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0011934 abnormal branching involved in pancreas development "any anomaly in the process in which the branches of the developing pancreas are generated and organized" [GO:0061114]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0011935 abnormal pancreatic bud formation "any anomaly in the process in which the foregut region specified to become the pancreas forms a bud" [GO:0061130]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0012246 abnormal hepatic cord morphology "any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [MGI:anna]
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Allelic Composition: Notch1tm2Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0012509 neural tube degeneration "a retrogressive impairment of function or destruction of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord)" [MGI:anna]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0012725 small sebaceous gland "decreased size of the sebum secreting glands of the hair shaft" [MGI:mnk]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0013464 decreased conjunctiva goblet cell number "fewer than normal numbers of the mucin-secreting cells found on the conjunctival epithelium; goblet cell loss has been reported in several inflammatory diseases of the ocular surface, including Stevens-Johnson syndrome, ocular mucous membrane pemphigoid, alkali burn, neutrophilic keratitis, graft-versus-host-disease, and Sjogrens s syndrome" [MGI:Anna]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0013925 abnormal vascular plexus formation 
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch3tm1Grid/Notch3tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0014148 lacrimal gland degeneration "a retrogressive impairment of function or destruction of the tubuloacinar exocrine glands that secrete the aqueous layer of the tear film (tears); mice have two lacrimal glands (intra- and exorbital)" [MGI:Anna]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0014154 Meibomian gland degeneration "a retrogressive impairment of function or destruction of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate" [ISBN:0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055022 Cntn1 / P12960 / Mus musculus contactin 1 (Cntn1), transcript variant 4, mRNA. / Q12860* / contactin 1*  / complex
 ENSMUSG00000003458 Ncstn / P57716 / Nicastrin / Q92542*  / reaction
 ENSMUSG00000015750 Aph1a / Q8BVF7 / Gamma-secretase subunit APH-1A / Q96BI3* / aph-1 homolog A, gamma-secretase subunit*  / reaction
 ENSMUSG00000054693 Adam10 / O35598 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672* / ADAM metallopeptidase domain 10*  / complex
 ENSMUSG00000027276 Jag1 / Q9QXX0 / Protein jagged-1 / P78504* / jagged 1*  / complex / reaction
 ENSMUSG00000029603 Dtx1 / Q61010 / E3 ubiquitin-protein ligase DTX1 / Q86Y01* / deltex E3 ubiquitin ligase 1*  / reaction / complex
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / complex
 ENSMUSG00000036766 Dner / Q8JZM4 / Delta and Notch-like epidermal growth factor-related receptor / Q8NFT8* / delta/notch like EGF repeat containing*  / complex / reaction
 ENSMUSG00000002799 Jag2 / Q9QYE5 / Protein jagged-2 / Q9Y219* / jagged 2*  / complex / reaction
 ENSMUSG00000021039 Snw1 / SNW domain containing 1 / Q13573*  / complex
 ENSMUSG00000021224 Numb / Q9QZS3 / NUMB, endocytic adaptor protein / P49757*  / complex / reaction
 ENSMUSG00000032375 Aph1b / Q8C7N7 / Gamma-secretase subunit APH-1B / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*  / reaction
 ENSMUSG00000027598 Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*  / complex / reaction
 ENSMUSG00000034064 Q8BYB9 / Poglut1 / protein O-glucosyltransferase 1 / Q8NBL1*  / reaction
 ENSMUSG00000029570 Lfng / O09010 / Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe / Q8NES3* / LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase*  / reaction
 ENSMUSG00000019969 Psen1 / P49769 / presenilin 1 / P49768*  / reaction
 ENSMUSG00000036835 Psenen / Q9CQR7 / Gamma-secretase subunit PEN-2 / Q9NZ42* / AD000671.1* / presenilin enhancer gamma-secretase subunit*  / reaction
 ENSMUSG00000039191 Rbpj / P31266 / Recombining binding protein suppressor of hairless / Q06330* / recombination signal binding protein for immunoglobulin kappa J region*  / complex
 ENSMUSG00000053040 Aph1c / Q9DCZ9 / Putative gamma-secretase subunit APH-1C / APH1B* / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*  / reaction
 ENSMUSG00000027314 Dll4 / Q9JI71 / Delta-like protein 4 / Q9NR61* / delta like canonical Notch ligand 4*  / complex / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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