ENSGALG00000002375


Gallus gallus

Features
Gene ID: ENSGALG00000002375
  
Biological name :NOTCH1
  
Synonyms : NOTCH1
  
Possible biological names infered from orthology : Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531 / Q01705
  
Species: Gallus gallus
  
Chr. number: 17
Strand: 1
Band:
Gene start: 8295293
Gene end: 8329319
  
Corresponding Affymetrix probe sets: Gga.16356.1.S1_at (Chicken Array)   Gga.182.1.S1_at (Chicken Array)   Gga.3837.1.S1_at (Chicken Array)   Gga.9548.1.S1_at (Chicken Array)   GgaAffx.1586.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003746
NCBI entrez gene - 395655     See in Manteia.
RefSeq - NM_001030295
RefSeq - XM_015279324
RefSeq - XM_015279325
RefSeq Peptide - NP_001025466
swissprot - F1NZ70
Ensembl - ENSGALG00000002375
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 notch1aENSDARG00000103554Danio rerio
 notch1bENSDARG00000052094Danio rerio
 NOTCH1ENSG00000148400Homo sapiens
 Notch1ENSMUSG00000026923Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOTCH2 / Q04721*ENSGALG0000000292251
JAG2 / jagged 2 / Q9QYE5* / Q9Y219* / Protein jagged-2 *ENSGALG0000001169614
JAG1 / jagged 1 / P78504* / Q9QXX0* / Protein jagged-1 *ENSGALG0000000902013
SNED1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSGALG0000004359612
ENSGALG0000001618311
DLL1 / delta-like protein 1 precursor / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSGALG000000111828
DLL4 / delta like canonical Notch ligand 4 / Q9JI71* / Q9NR61* / Delta-like protein 4 *ENSGALG000000085147
ENSGALG000000399976


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR008297  Notch
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022362  Neurogenic locus Notch 1
 IPR024600  Domain of unknown function DUF3454, notch


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001708 cell fate specification IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0003157 endocardium development IEA
 biological_processGO:0003160 endocardium morphogenesis IEA
 biological_processGO:0003162 atrioventricular node development IEA
 biological_processGO:0003169 coronary vein morphogenesis IEA
 biological_processGO:0003180 aortic valve morphogenesis IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IEA
 biological_processGO:0003184 pulmonary valve morphogenesis IEA
 biological_processGO:0003192 mitral valve formation IEA
 biological_processGO:0003197 endocardial cushion development IEA
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0003207 cardiac chamber formation IEA
 biological_processGO:0003208 cardiac ventricle morphogenesis IEA
 biological_processGO:0003209 cardiac atrium morphogenesis IEA
 biological_processGO:0003213 cardiac right atrium morphogenesis IEA
 biological_processGO:0003214 cardiac left ventricle morphogenesis IEA
 biological_processGO:0003219 cardiac right ventricle formation IEA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0003241 growth involved in heart morphogenesis IEA
 biological_processGO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IEA
 biological_processGO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation IEA
 biological_processGO:0003273 cell migration involved in endocardial cushion formation IEA
 biological_processGO:0003344 pericardium morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006959 humoral immune response IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007386 compartment pattern specification IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007440 foregut morphogenesis IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IEA
 biological_processGO:0009912 auditory receptor cell fate commitment IEA
 biological_processGO:0010001 glial cell differentiation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IEA
 biological_processGO:0010832 negative regulation of myotube differentiation IEA
 biological_processGO:0014031 mesenchymal cell development IEA
 biological_processGO:0014807 regulation of somitogenesis IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0032495 response to muramyl dipeptide IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0035148 tube formation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045607 regulation of inner ear auditory receptor cell differentiation IEA
 biological_processGO:0045608 negative regulation of inner ear auditory receptor cell differentiation IEA
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045955 negative regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0045967 negative regulation of growth rate IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0048103 somatic stem cell division IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0048845 venous blood vessel morphogenesis IEA
 biological_processGO:0050678 regulation of epithelial cell proliferation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0050793 regulation of developmental process IEA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IEA
 biological_processGO:0060038 cardiac muscle cell proliferation IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IEA
 biological_processGO:0060411 cardiac septum morphogenesis IEA
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0060740 prostate gland epithelium morphogenesis IEA
 biological_processGO:0060768 regulation of epithelial cell proliferation involved in prostate gland development IEA
 biological_processGO:0060842 arterial endothelial cell differentiation IEA
 biological_processGO:0060843 venous endothelial cell differentiation IEA
 biological_processGO:0060948 cardiac vascular smooth muscle cell development IEA
 biological_processGO:0060956 endocardial cell differentiation IEA
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis IEA
 biological_processGO:0060982 coronary artery morphogenesis IEA
 biological_processGO:0061314 Notch signaling involved in heart development IEA
 biological_processGO:0061384 heart trabecula morphogenesis IEA
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070986 left/right axis specification IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0072017 distal tubule development IEA
 biological_processGO:0072044 collecting duct development IEA
 biological_processGO:0072144 glomerular mesangial cell development IEA
 biological_processGO:0072602 interleukin-4 secretion IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:1901201 regulation of extracellular matrix assembly IEA
 biological_processGO:1902263 apoptotic process involved in embryonic digit morphogenesis IEA
 biological_processGO:1903849 positive regulation of aorta morphogenesis IEA
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 biological_processGO:2000811 negative regulation of anoikis IEA
 biological_processGO:2000974 negative regulation of pro-B cell differentiation IEA
 biological_processGO:2001027 negative regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0002193 MAML1-RBP-Jkappa- ICN1 complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
Activated NOTCH1 Transmits Signal to the Nucleus
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010501 SNW1 / SNW domain containing 1 / Q13573*  / complex
 ENSGALG00000002375 NOTCH1 / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*  / complex
 ENSGALG00000011696 JAG2 / jagged 2 / Q9QYE5* / Q9Y219* / Protein jagged-2 *  / complex / reaction
 ENSGALG00000008341 FURIN / furin, paired basic amino acid cleaving enzyme / P09958* / P23188*  / reaction






 

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