ENSGALG00000008514


Gallus gallus

Features
Gene ID: ENSGALG00000008514
  
Biological name :DLL4
  
Synonyms : delta like canonical Notch ligand 4 / DLL4
  
Possible biological names infered from orthology : Delta-like protein 4 / Q9JI71 / Q9NR61
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 24405626
Gene end: 24413310
  
Corresponding Affymetrix probe sets: GgaAffx.22611.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013851
NCBI entrez gene - 423208     See in Manteia.
RefSeq - XM_004941616
RefSeq - XM_421132
swissprot - F1P0R6
Ensembl - ENSGALG00000008514
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dll4ENSDARG00000070425Danio rerio
 DLL4ENSG00000128917Homo sapiens
 Dll4ENSMUSG00000027314Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DLL1 / delta-like protein 1 precursor / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSGALG0000001118252
JAG2 / jagged 2 / Q9QYE5* / Q9Y219* / Protein jagged-2 *ENSGALG0000001169631
NOTCH2 / Q04721*ENSGALG0000000292228
NOTCH1 / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSGALG0000000237526
JAG1 / jagged 1 / P78504* / Q9QXX0* / Protein jagged-1 *ENSGALG0000000902024
SNED1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSGALG0000004359616
ENSGALG0000001618311
ENSGALG000000399979


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0003208 cardiac ventricle morphogenesis IEA
 biological_processGO:0003209 cardiac atrium morphogenesis IEA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0003344 pericardium morphogenesis IEA
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0035912 dorsal aorta morphogenesis IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0060579 ventral spinal cord interneuron fate commitment IEA
 biological_processGO:0061074 regulation of neural retina development IEA
 biological_processGO:0061314 Notch signaling involved in heart development IEA
 biological_processGO:0072554 blood vessel lumenization IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
NOTCH2 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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