ENSMUSG00000027314


Mus musculus

Features
Gene ID: ENSMUSG00000027314
  
Biological name :Dll4
  
Synonyms : Delta-like protein 4 / Dll4 / Q9JI71
  
Possible biological names infered from orthology : delta like canonical Notch ligand 4 / Q9NR61
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119325784
Gene end: 119335962
  
Corresponding Affymetrix probe sets: 10474958 (MoGene1.0st)   1421826_at (Mouse Genome 430 2.0 Array)   1421827_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099575
NCBI entrez gene - 54485     See in Manteia.
MGI - MGI:1859388
RefSeq - NM_019454
RefSeq Peptide - NP_062327
swissprot - Q9JI71
Ensembl - ENSMUSG00000027314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dll4ENSDARG00000070425Danio rerio
 DLL4ENSGALG00000008514Gallus gallus
 DLL4ENSG00000128917Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dll1 / Q61483 / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / O00548* / delta like canonical Notch ligand 1*ENSMUSG0000001477349
Jag1 / Q9QXX0 / Protein jagged-1 / P78504* / jagged 1*ENSMUSG0000002727630
Jag2 / Q9QYE5 / Protein jagged-2 / Q9Y219* / jagged 2*ENSMUSG0000000279930
Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*ENSMUSG0000002692328
Notch2 / Q04721*ENSMUSG0000002787827
Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*ENSMUSG0000003814627
Notch4 / Q99466*ENSMUSG0000001546825
Sned1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSMUSG0000004779321


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0003208 cardiac ventricle morphogenesis IMP
 biological_processGO:0003209 cardiac atrium morphogenesis IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0003344 pericardium morphogenesis IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030217 T cell differentiation IDA
 biological_processGO:0035912 dorsal aorta morphogenesis IMP
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IDA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060579 ventral spinal cord interneuron fate commitment IEA
 biological_processGO:0061074 regulation of neural retina development IMP
 biological_processGO:0061314 Notch signaling involved in heart development IMP
 biological_processGO:0072554 blood vessel lumenization IMP
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005112 Notch binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000265 atretic vasculature "absence or disorganization of vasculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571]
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Allelic Composition: Dll4tm1Jrt/Dll4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Dll4tm1Grid/Dll4+
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Dll4tm2.1Vlcg/Dll4+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dll4tm1Frad/Dll4tm1Frad,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: B6.Cg-Dll4tm1Frad Foxn1tm3(cre)Nrm

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Olig3tm1Qiu/Olig3tm1Qiu
Genetic Background: Not Specified

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Olig3tm1Qiu/Olig3tm1Qiu
Genetic Background: Not Specified

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfe2l1tm1Mym/Nfe2l1tm1Mym,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

Allelic Composition: Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Dll4tm3.1Vlcg/Dll4+,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Olig3tm1Qiu/Olig3tm1Qiu
Genetic Background: Not Specified

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Dll4tm2.1Vlcg/Dll4tm2.1Vlcg,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0003228 abnormal sinus venosus "malformation in the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0003230 abnormal umbilical artery "malformation of the blood vessel of the umbilical cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0003410 abnormal artery development "anomaly in the process of forming the blood vessels that carry blood away from the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0003411 abnormal vein development "anomaly in the process of forming the blood vessels that carry blood to the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Dll4tm1Grid/Dll4+
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Dll4tm1Jrt/Dll4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Dll4tm1Grid/Dll4+
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Dll4tm1Grid/Dll4+
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll4tm1Jrt/Dll4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0004784 abnormal anterior cardinal vein morphology "any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Dll4tm1Grid/Dll4+
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0004786 abnormal common cardinal vein morphology "any structural anomaly of the anastomosis of the anterior and posterior cardinal veins that returns blood to the developing heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dll4tm1Grid/Dll4+
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Dll4tm1Jrt/Dll4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Dll4tm1Grid/Dll4+
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dll4tm1Frad/Dll4tm1Frad,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: B6.Cg-Dll4tm1Frad Foxn1tm3(cre)Nrm

Allelic Composition: Dll4tm1Kaho/Dll4tm1Kaho,Tg(Foxn1-cre)8Ghr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dll4tm1Jrt/Dll4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0006093 arteriovenous malformation "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125]
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Allelic Composition: Dll4tm1Grid/Dll4+
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll4tm1Frad/Dll4tm1Frad,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: B6.Cg-Dll4tm1Frad Foxn1tm3(cre)Nrm

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll4tm1Frad/Dll4tm1Frad,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: B6.Cg-Dll4tm1Frad Foxn1tm3(cre)Nrm

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll4tm1Frad/Dll4tm1Frad,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: B6.Cg-Dll4tm1Frad Foxn1tm3(cre)Nrm

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Dll4tm1Frad/Dll4tm1Frad,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: B6.Cg-Dll4tm1Frad Foxn1tm3(cre)Nrm

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Dll4tm2.1Vlcg/Dll4+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Nodaltm1Rob/Nodaltm5Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Dll4tm1Jrt/Dll4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dll4tm1Grid/Dll4+
Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dll4tm1Jrt/Dll4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac * ICR

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Dll4tm1Jrt/Dll4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0012730 abnormal internal carotid artery morphology "any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes" [MGI:anna]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Dll4tm1Nwg/Dll4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054693 Adam10 / O35598 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672* / ADAM metallopeptidase domain 10*  / reaction
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / complex / reaction
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / reaction / complex
 ENSMUSG00000027878 Notch2 / Q04721*  / complex / reaction






 

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