ENSMUSG00000027878


Mus musculus

Features
Gene ID: ENSMUSG00000027878
  
Biological name :Notch2
  
Synonyms : Notch2
  
Possible biological names infered from orthology : Q04721
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 98013527
Gene end: 98150361
  
Corresponding Affymetrix probe sets: 10494595 (MoGene1.0st)   1451889_at (Mouse Genome 430 2.0 Array)   1455556_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078741
NCBI entrez gene - 18129     See in Manteia.
MGI - MGI:97364
RefSeq - NM_010928
RefSeq Peptide - NP_035058
swissprot - G5E8J0
Ensembl - ENSMUSG00000027878
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 notch2ENSDARG00000043130Danio rerio
 si:ch73-281k2.5ENSDARG00000104329Danio rerio
 NOTCH2ENSGALG00000002922Gallus gallus
 NOTCH2ENSG00000134250Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*ENSMUSG0000002692354
Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*ENSMUSG0000003814648
Notch4 / Q99466*ENSMUSG0000001546833
Jag2 / Q9QYE5 / Protein jagged-2 / Q9Y219* / jagged 2*ENSMUSG0000000279915
Sned1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSMUSG0000004779315
Jag1 / Q9QXX0 / Protein jagged-1 / P78504* / jagged 1*ENSMUSG0000002727615
Dll1 / Q61483 / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / O00548* / delta like canonical Notch ligand 1*ENSMUSG000000147738
Dll4 / Q9JI71 / Delta-like protein 4 / Q9NR61* / delta like canonical Notch ligand 4*ENSMUSG000000273148


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR008297  Notch
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022336  Neurogenic locus Notch 2
 IPR024600  Domain of unknown function DUF3454, notch
 IPR035993  Notch-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003184 pulmonary valve morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045967 negative regulation of growth rate IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0050793 regulation of developmental process IEA
 biological_processGO:0060413 atrial septum morphogenesis IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:2001204 regulation of osteoclast development IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
NOTCH2 intracellular domain regulates transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus
Notch-HLH transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Klhl3tm2.1Esoh/Klhl3tm2.1Esoh
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2Gt(AG0498)Wtsi/Notch2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gusbmps/Gusbmps
Genetic Background: B6.C-H2-Kbm1/ByBir-Gusbmps/J

Allelic Composition: Notch1tm1Agt/Notch1+,Notch2tm1Frad/Notch2tm1Frad,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2+,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Notch2tm1Frad/Notch2tm1Frad,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * DBA/2

 MP:0000388 absent inner root sheath "missing epidermally derived layer surrounding the hair follicle; innermost of two layers" [J:65047]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Klhl3tm2.1Esoh/Klhl3tm2.1Esoh
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0000610 cholestasis "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0000648 absent sebaceous gland "missing the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: CbfbTgTn(sb-cHS4,Tyr)2512E-2Ove/CbfbTgTn(sb-cHS4,Tyr)2512E-2Ove
Genetic Background: FVB/N-CbfbTgTn(sb-cHS4,Tyr)2512E-2Ove

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: FVB.129-Lfngtm1.2Egan

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

Allelic Composition: Notch2tm2Grid/Notch2tm3Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Jag1tm1Grid/Jag1+,Notch2tm1Grid/Notch2+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Notch2tm2Grid/Notch2tm3Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Notch2tm3.1Grid/Notch2tm3.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Notch2Gt(AG0498)Wtsi/Notch2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

Allelic Composition: Notch2tm2Grid/Notch2tm3Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grm1rcw-3J/Grm1rcw-3J
Genetic Background: C57BL/6J-Grm1rcw-3J/GrsrJ

 MP:0001711 abnormal placenta 
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Notch2tm3.1Grid/Notch2tm3.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129 * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-13H/Y
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Frad/Notch2tm1Frad,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Notch2tm1Bmc/Notch2tm1Bmc
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Notch2Gt(AG0498)Wtsi/Notch2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Jag1tm1.1Loo/Jag1+,Notch2tm1Grid/Notch2+,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Notch2tm1.1(cre/ERT2)Sat/Notch2+
Genetic Background: C57BL/6-Notch2tm1.1(cre/ERT2)Sat

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm1.1With/Irs2tm1.1With
Genetic Background: B6.129S6-Irs2tm1.1With

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lcp2tm4Gak/Lcp2tm4Gak,Tg(TcrAND)53Hed/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

Allelic Composition: Notch2tm2Grid/Notch2tm3Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

Allelic Composition: Jag1tm1Grid/Jag1+,Notch2tm3.1Grid/Notch2+
Genetic Background: B6.129S1-Jag1tm1Grid Notch2tm3.1Grid

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Jag1tm1Grid/Jag1+,Notch2tm1Grid/Notch2+
Genetic Background: involves: 129S1/Sv

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

Allelic Composition: Notch2tm2Grid/Notch2tm3Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

Allelic Composition: Notch2tm2Grid/Notch2tm3Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S1/Sv

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Notch1tm6.1Rko/Notch1+,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm3.1Grid/Notch2tm3.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0004194 abnormal kidney pelvis morphology "any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm1rcw-3J/Grm1rcw-3J
Genetic Background: C57BL/6J-Grm1rcw-3J/GrsrJ

 MP:0004258 abnormal placenta size "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0004381 abnormal hair follicle melanocyte morphology "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1+,Notch2tm1Frad/Notch2tm1Frad,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0004560 abnormal chorionic plate morphology "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0004834 ovary hemorrhage "presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S1/Sv

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0005083 abnormal biliary tract morphology "anomalous structure or development of the gall bladder or its ducts " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jag1tm1Grid/Jag1+,Poglut1Gt(IST10323G11)Tigm/Poglut1+
Genetic Background: B6.Cg-Jag1tm1Grid Poglut1Gt(IST10323G11)Tigm

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

Allelic Composition: Notch2tm2Grid/Notch2tm3Grid,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: FVB.129-Lfngtm1.2Egan

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0008137 absent podocytes "absence of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

Allelic Composition: Notch2Gt(betageo)1Byg/Notch2+
Genetic Background: B6.129P2-Notch2Gt(betageo)1Byg

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Notch2tm1Hhi/Notch2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Notch2tm1Frad/Notch2tm1Frad,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1.1(cre/ERT2)Sat/Notch1+
Genetic Background: C57BL/6-Notch1tm1.1(cre/ERT2)Sat

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Tg(Msx2-cre)5Rem/0
Genetic Background: Not Specified

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009165 abnormal endocrine pancreas morphology "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0009444 ovarian follicular cyst "a sac filled with fluid that may develop when the structure containing the egg fails to break open at the time of ovulation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S1/Sv

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S1/Sv

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0010451 kidney microaneurysm "focal dilation of arteriocapillary junctions in the kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010457 pulmonary artery stenosis "constriction or narrowing of the pulmonary artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010459 supravalvar pulmonary trunk stenosis "diffuse constriction or narrowing of the pulmonary trunk distal to the pulmonary valve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010711 persistent hyperplastic primary vitreous "persistence of the embryonic fibrovascular mesodermal tissue located between the optic cup and lens vesicle that normally regresses during the development of the vitreous body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0010965 decreased compact bone volume 
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Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0010968 decreased compact bone area "reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: FVB.129-Lfngtm1.2Egan

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch2tm2Hhi/Notch2tm2Hhi
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm3.1Grid/Notch2tm3.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011181 increased hematopoietic cell number "greater than expected number of cells of the hematopoietic lineage" [MGI:csmith]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Notch1tm2Rko/Notch1tm2Rko,Notch2tm1Rko/Notch2tm1Rko,Notch3Gt(PST033)Byg/Notch3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011429 absent mesangial cell "absence of the phagocytic cells in the capillary tuft of the renal glomerulus, normally interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011934 abnormal branching involved in pancreas development "any anomaly in the process in which the branches of the developing pancreas are generated and organized" [GO:0061114]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0011935 abnormal pancreatic bud formation "any anomaly in the process in which the foregut region specified to become the pancreas forms a bud" [GO:0061130]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0012537 abnormal hyaloid artery morphology "any structural anomaly of the artery which arises from the dorsal ophthalmic artery and enters the eye cup through the optic (choroid) fissure; the hyaloid artery is contained within the optic stalk of the eye, extends from the optic disc through the vitreous humor to the lens, and serves to supply nutrients to the developing lens in the growing fetus; it usually regresses (around 2 weeks after birth in mice and before birth in humans), with its proximal portion remaining as the central artery of the retina; regression of the hyaloid artery leaves a clear central zone through the vitreous humor, called the hyaloid canal or Cloquet s canal" [MGI:anna]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Notch1tm1Rko/Notch1tm1Rko
Genetic Background: involves: 129X1/SvJ

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Notch2tm2.2Ecan/Notch2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Notch2tm1.1Ecan/Notch2+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Notch2tm2.1Ecan/Notch2tm2.1Ecan,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: C57BL/6J * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039191 Rbpj / P31266 / Recombining binding protein suppressor of hairless / Q06330* / recombination signal binding protein for immunoglobulin kappa J region*  / reaction / complex
 ENSMUSG00000031925 Maml2 / mastermind-like protein 2 isoform 1 / Q8IZL2* / mastermind like transcriptional coactivator 2*  / complex / reaction
 ENSMUSG00000050567 Maml1 / Q6T264 / Mastermind-like protein 1 / Q92585* / mastermind like transcriptional coactivator 1*  / complex / reaction
 ENSMUSG00000027878 Notch2 / Q04721*  / complex
 ENSMUSG00000027239 Mdk / P12025 / Midkine / P21741*  / complex / reaction
 ENSMUSG00000027314 Dll4 / Q9JI71 / Delta-like protein 4 / Q9NR61* / delta like canonical Notch ligand 4*  / complex / reaction
 ENSMUSG00000061143 Maml3 / mastermind like transcriptional coactivator 3 / Q96JK9*  / complex / reaction






 

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