ENSMUSG00000061143


Mus musculus

Features
Gene ID: ENSMUSG00000061143
  
Biological name :Maml3
  
Synonyms : Maml3 / mastermind like transcriptional coactivator 3
  
Possible biological names infered from orthology : Q96JK9
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: C
Gene start: 51685907
Gene end: 52105076
  
Corresponding Affymetrix probe sets: 10498076 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000112637
Ensembl peptide - ENSMUSP00000113677
NCBI entrez gene - 433586     See in Manteia.
MGI - MGI:2389461
RefSeq - NM_001004176
RefSeq - XM_006501645
RefSeq Peptide - NP_001004176
swissprot - E9Q6E8
swissprot - D4QGC2
Ensembl - ENSMUSG00000061143
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maml3ENSDARG00000079552Danio rerio
 MAML3ENSGALG00000009809Gallus gallus
 MAML3ENSG00000196782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Maml1 / Q6T264 / Mastermind-like protein 1 / Q92585* / mastermind like transcriptional coactivator 1*ENSMUSG0000005056728
Maml2 / mastermind-like protein 2 isoform 1 / Q8IZL2* / mastermind like transcriptional coactivator 2*ENSMUSG000000319258


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR019082  Neurogenic mastermind-like, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway ISO
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

Allelic Composition: Maml1tm1Mkit/Maml1tm1Mkit,Maml3tm1Mkit/Maml3tm1Mkit
Genetic Background: B6.129P2-Maml3tm1Mkit Maml1tm1Mkit

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039191 Rbpj / P31266 / Recombining binding protein suppressor of hairless / Q06330* / recombination signal binding protein for immunoglobulin kappa J region*  / reaction / complex
 ENSMUSG00000027878 Notch2 / Q04721*  / complex / reaction
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / complex






 

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