ENSMUSG00000039191


Mus musculus

Features
Gene ID: ENSMUSG00000039191
  
Biological name :Rbpj
  
Synonyms : P31266 / Rbpj / Recombining binding protein suppressor of hairless
  
Possible biological names infered from orthology : Q06330 / recombination signal binding protein for immunoglobulin kappa J region
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C1
Gene start: 53466152
Gene end: 53657362
  
Corresponding Affymetrix probe sets: 10521911 (MoGene1.0st)   10521913 (MoGene1.0st)   1418114_at (Mouse Genome 430 2.0 Array)   1448957_at (Mouse Genome 430 2.0 Array)   1454896_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143846
Ensembl peptide - ENSMUSP00000109496
Ensembl peptide - ENSMUSP00000143866
Ensembl peptide - ENSMUSP00000144617
Ensembl peptide - ENSMUSP00000040694
Ensembl peptide - ENSMUSP00000084618
NCBI entrez gene - 19664     See in Manteia.
MGI - MGI:96522
RefSeq - XM_017320743
RefSeq - NM_001080927
RefSeq - NM_001080928
RefSeq - NM_001277116
RefSeq - NM_009035
RefSeq - XM_006503796
RefSeq - XM_006503797
RefSeq - XM_006503799
RefSeq - XM_017320742
RefSeq Peptide - NP_001264045
RefSeq Peptide - NP_033061
RefSeq Peptide - NP_001074396
RefSeq Peptide - NP_001074397
swissprot - P31266
swissprot - Q3U6F1
swissprot - Q3UM17
swissprot - A0A0J9YTV5
swissprot - E9Q7W0
swissprot - A0A0J9YVE0
Ensembl - ENSMUSG00000039191
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbpjaENSDARG00000003398Danio rerio
 rbpjbENSDARG00000052091Danio rerio
 RBPJENSGALG00000014365Gallus gallus
 RBPJENSG00000168214Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbpjl / O08674 / recombination signal binding protein for immunoglobulin kappa J region-like / Q9UBG7*ENSMUSG0000001700746


Protein motifs (from Interpro)
Interpro ID Name
 IPR008967  p53-like transcription factor, DNA-binding
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015350  Beta-trefoil DNA-binding domain
 IPR015351  RBP-J/Cbf11/Cbf12, DNA binding
 IPR036358  Beta-trefoil domain superfamily
 IPR037095  RBP-J/Cbf11/Cbf12, DNA binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001756 somitogenesis TAS
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0001947 heart looping TAS
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002437 inflammatory response to antigenic stimulus IMP
 biological_processGO:0003139 secondary heart field specification IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003157 endocardium development IMP
 biological_processGO:0003160 endocardium morphogenesis IMP
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:0003214 cardiac left ventricle morphogenesis IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0007219 Notch signaling pathway ISO
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target ISO
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009912 auditory receptor cell fate commitment IMP
 biological_processGO:0009957 epidermal cell fate specification IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0030279 negative regulation of ossification IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0035481 positive regulation of Notch signaling pathway involved in heart induction TAS
 biological_processGO:0035912 dorsal aorta morphogenesis IMP
 biological_processGO:0036302 atrioventricular canal development IMP
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048505 regulation of timing of cell differentiation IMP
 biological_processGO:0048733 sebaceous gland development IMP
 biological_processGO:0048820 hair follicle maturation IMP
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060486 Clara cell differentiation IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0060844 arterial endothelial cell fate commitment IMP
 biological_processGO:0060853 Notch signaling pathway involved in arterial endothelial cell fate commitment IC
 biological_processGO:0061344 regulation of cell adhesion involved in heart morphogenesis IC
 biological_processGO:0061371 determination of heart left/right asymmetry TAS
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISS
 biological_processGO:0072554 blood vessel lumenization IMP
 biological_processGO:0072602 interleukin-4 secretion IMP
 biological_processGO:0097101 blood vessel endothelial cell fate specification IGI
 biological_processGO:1901186 positive regulation of ERBB signaling pathway IMP
 biological_processGO:1901189 positive regulation of ephrin receptor signaling pathway IMP
 biological_processGO:1901297 positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IMP
 biological_processGO:2000138 positive regulation of cell proliferation involved in heart morphogenesis IMP
 cellular_componentGO:0002193 MAML1-RBP-Jkappa- ICN1 complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0070491 repressing transcription factor binding ISO


Pathways (from Reactome)
Pathway description
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Efnb2tm1And/Efnb2+,Rbpjtm1Kyo/Rbpjtm1Kyo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Rbpjtm1Hon/Rbpjtm1Hon,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CBA

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rbpjtm1Kyo/Rbpjtm1Hon,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Rbpjtm1Hon/Rbpjtm1Hon,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB * SJL

 MP:0001280 loss of vibrissae "inability to retain the whiskers" [J:45400]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Tg(Gfap-GFAP*R239H)60TMIke/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Efnb2tm1And/Efnb2+,Rbpjtm1Kyo/Rbpjtm1Kyo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Tg(Gfap-GFAP*R239H)60TMIke/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Tg(Gfap-GFAP*R239H)60TMIke/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros,Unc13btm1Rmnd/Unc13btm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Tg(Pax7-cre/ERT2)1Cbm/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1.1Wtp/Srftm1.1Wtp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0002280 abnormal intercostal muscle morphology "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tacc3tm1Tno/Tacc3tm1.2Tno
Genetic Background: involves: C57BL/6

 MP:0003246 loss of GABA neurons "loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Tg(Pax7-cre/ERT2)1Cbm/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

 MP:0003247 abnormal glutaminergic neuron "malformation or absence of the neurons that utilize glutamate as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Tg(Pax7-cre/ERT2)1Cbm/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

 MP:0003359 hypaxial muscle hypoplasia "reduced cell number in the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0003414 epidermal cyst "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB * SJL

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Tg(Gfap-GFAP*R239H)60TMIke/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbpjtm1Kyo/Rbpjtm1Hon,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0004248 abnormal epaxial muscle morphology "any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles" [PMID:1591996]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Con/Notch1tm1Grid,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004784 abnormal anterior cardinal vein morphology "any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rbpjtm1Kyo/Rbpjtm1Hon,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004786 abnormal common cardinal vein morphology "any structural anomaly of the anastomosis of the anterior and posterior cardinal veins that returns blood to the developing heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rbpjtm1Kyo/Rbpjtm1Hon,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Rbpjtm1Kyo/Rbpjtm1Hon,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Lck-cre)19Hhan/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Tg(Pax7-cre/ERT2)1Cbm/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fbxw7tm1Kei/Fbxw7tm1Kei,Rbpjtm1Hon/Rbpjtm1Hon,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm1And/Efnb2+,Rbpjtm1Kyo/Rbpjtm1Kyo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Lck-cre)19Hhan/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0006093 arteriovenous malformation "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125]
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Allelic Composition: Rbpjtm1Kyo/Rbpjtm1Hon,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB * SJL

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Lck-cre)19Hhan/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grik2tm1Sfh/Grik2tm1Sfh
Genetic Background: involves: 129S1/Sv

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008137 absent podocytes "absence of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Notch1tm1Con/Notch1tm1Grid,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008200 decreased follicular dendritic cell number "reduced number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009149 decreased pancreatic acinar cell number "reduced number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0009159 increased pancreatic acinar cell number "increased number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0009179 abnormal pancreatic alpha cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors" [MESH:A03.734.414.065]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Lck-cre)19Hhan/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0009408 decreased skeletal muscle fiber density "decrease in the number of skeletal muscle fibers in a given cross-sectional area of a skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Tg(Pax7-cre/ERT2)1Cbm/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

 MP:0010171 abnormal centroacinar cell of Langerhans morphology "any structural anomaly of cells that line the pancreatic ducts that secrete mucins and an aqueous bicarbonate solution under stimulation by the hormone secretin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010183 abnormal CD4-positive helper T cell morphology "any structural anomaly of a CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions" [CL:0000492, ISBN:0781735149]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(Lck-cre)19Hhan/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0010198 decreased lymphatic vessel endothelial cell number "reduced number of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0010942 abnormal respiratory epithelium morphology "any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pofut1tm2Pst/Pofut1tm1Pst,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0011071 absent Clara cells "absence of the rounded, club-shaped, nonciliated cells found between ciliated cells in the bronchiolar epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Rbpjtm1Hon/Rbpjtm1Hon,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Notch1tm1Con/Notch1tm1Grid,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Rbpjtm1Hon/Rbpjtm1Hon,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / complex
 ENSMUSG00000050567 Maml1 / Q6T264 / Mastermind-like protein 1 / Q92585* / mastermind like transcriptional coactivator 1*  / complex / reaction
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / complex
 ENSMUSG00000027878 Notch2 / Q04721*  / complex / reaction
 ENSMUSG00000061143 Maml3 / mastermind like transcriptional coactivator 3 / Q96JK9*  / reaction / complex
 ENSMUSG00000031925 Maml2 / mastermind-like protein 2 isoform 1 / Q8IZL2* / mastermind like transcriptional coactivator 2*  / complex / reaction
 ENSMUSG00000021039 Snw1 / SNW domain containing 1 / Q13573*  / complex
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction






 

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