ENSDARG00000052091


Danio rerio

Features
Gene ID: ENSDARG00000052091
  
Biological name :rbpjb
  
Synonyms : rbpjb / recombination signal binding protein for immunoglobulin kappa J region b
  
Possible biological names infered from orthology : P31266 / Q06330 / RBPJ / recombination signal binding protein for immunoglobulin kappa J region / Recombining binding protein suppressor of hairless
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 62080456
Gene end: 62206933
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000087012
NCBI entrez gene - 563306     See in Manteia.
RefSeq - NM_001083551
RefSeq Peptide - NP_001077020
swissprot - A4FTT4
ZFIN ID - ZDB-GENE-070319-1
Ensembl - ENSDARG00000052091
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RBPJENSGALG00000014365Gallus gallus
 RBPJENSG00000168214Homo sapiens
 RbpjENSMUSG00000039191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rbpja / recombination signal binding protein for immunoglobulin kappa J region a / RBPJ* / Q06330* / recombination signal binding protein for immunoglobulin kappa J region*ENSDARG0000000339889
rbpjl / recombination signal binding protein for immunoglobulin kappa J region-like / O08674* / Q9UBG7*ENSDARG0000007414850


Protein motifs (from Interpro)
Interpro ID Name
 IPR008967  p53-like transcription factor, DNA-binding
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015350  Beta-trefoil DNA-binding domain
 IPR015351  RBP-J/Cbf11/Cbf12, DNA binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0002040 sprouting angiogenesis IGI
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007368 determination of left/right symmetry IGI
 biological_processGO:0007507 heart development IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030325 adrenal gland development IGI
 biological_processGO:0039021 pronephric glomerulus development IGI
 biological_processGO:0039022 pronephric duct development IGI
 biological_processGO:0060840 artery development IGI
 biological_processGO:0072149 glomerular visceral epithelial cell fate commitment IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
NOTCH2 intracellular domain regulates transcription
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system cellular quality , abnormal
Show

 ZFA:0000029 hindbrain hindbrain epithelium disorganized , abnormal
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 ZFA:0000114 heart heart position , abnormal
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 ZFA:0000155 somite somite spatial pattern , abnormal
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 ZFA:0000295 trigeminal ganglion trigeminal ganglion increased size , abnormal
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 ZFA:0000360 heart tube heart tube decreased length , abnormal
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 ZFA:0000563 pectoral fin musculature pectoral fin musculature contractile fiber malformed , abnormal
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 ZFA:0001061 intersegmental artery intersegmental artery blood vessel endothelial cell increased amount , abnormal
intersegmental artery structure , abnormal
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 ZFA:0001094 whole organism whole organism increased distribution , abnormal
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 ZFA:0001117 post-vent region post-vent region structure , abnormal
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 ZFA:0001161 pectoral fin pectoral fin actin filament mislocalised , abnormal
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 ZFA:0001261 ventricular system ventricular system distended , abnormal
ventricular system increased accumulation nucleate erythrocyte , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature broken , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel structure , abnormal
intersegmental vessel mislocalised , abnormal
intersegmental vessel disorganized , abnormal
intersegmental vessel increased mass density , abnormal
intersegmental vessel has extra parts of type blood vessel , abnormal
intersegmental vessel has extra parts of type vascular sprouts , abnormal
intersegmental vessel cell increased amount , abnormal
intersegmental vessel cell amount , ameliorated
intersegmental vessel increased branchiness , abnormal
intersegmental vessel angiogenesis increased process quality , abnormal
intersegmental vessel angiogenesis process quality , ameliorated
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 ZFA:0001314 posterior lateral line ganglion posterior lateral line ganglion neuron increased amount , abnormal
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 ZFA:0001346 interrenal primordium interrenal primordium increased size , abnormal
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 ZFA:0001456 pectoral fin endoskeletal disc pectoral fin endoskeletal disc disorganized , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule morphology , abnormal
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 ZFA:0001673 pronephric podocyte pronephric podocyte decreased amount , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel blood vessel development occurrence , ameliorated
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic cell absent , abnormal
ventral wall of dorsal aorta endothelial cell absent , abnormal
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 ZFA:0005314 blood vessel blood vessel increased distribution , abnormal
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 ZFA:0005604 angiogenic sprout angiogenic sprout increased amount , abnormal
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 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell increased amount , abnormal
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 ZFA:0009052 motor neuron motor neuron increased amount , abnormal
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 ZFA:0009063 peripheral neuron peripheral neuron decreased length , abnormal
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 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron increased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte mislocalised , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076466 maml1 / mastermind-like transcriptional coactivator 1 / Q6T264* / Q92585* / Mastermind-like protein 1 *  / complex / reaction
 ENSDARG00000043130 notch2 / Q04721*  / reaction / complex
 ENSDARG00000104329 si:ch73-281k2.5 / NOTCH2* / Q04721*  / complex / reaction
 ENSDARG00000079552 maml3 / mastermind-like transcriptional coactivator 3 / Q96JK9*  / reaction / complex
 ENSDARG00000091563 snw1 / SNW domain containing 1 / Q13573*  / complex






 

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