ENSDARG00000003398


Danio rerio

Features
Gene ID: ENSDARG00000003398
  
Biological name :rbpja
  
Synonyms : rbpja / recombination signal binding protein for immunoglobulin kappa J region a
  
Possible biological names infered from orthology : P31266 / Q06330 / RBPJ / recombination signal binding protein for immunoglobulin kappa J region / Recombining binding protein suppressor of hairless
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 14454663
Gene end: 14464020
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000026585
NCBI entrez gene - 386772     See in Manteia.
RefSeq - NM_198878
RefSeq Peptide - NP_942579
swissprot - A4FTT3
ZFIN ID - ZDB-GENE-031117-1
Ensembl - ENSDARG00000003398
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RBPJENSGALG00000014365Gallus gallus
 RBPJENSG00000168214Homo sapiens
 RbpjENSMUSG00000039191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rbpjb / recombination signal binding protein for immunoglobulin kappa J region b / RBPJ* / Q06330* / P31266* / Recombining binding protein suppressor of hairless * / recombination signal bi...ENSDARG0000005209189
rbpjl / recombination signal binding protein for immunoglobulin kappa J region-like / O08674* / Q9UBG7*ENSDARG0000007414850


Protein motifs (from Interpro)
Interpro ID Name
 IPR008967  p53-like transcription factor, DNA-binding
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015350  Beta-trefoil DNA-binding domain
 IPR015351  RBP-J/Cbf11/Cbf12, DNA binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001757 somite specification IMP
 biological_processGO:0002040 sprouting angiogenesis IGI
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007219 Notch signaling pathway IMP
 biological_processGO:0007367 segment polarity determination IMP
 biological_processGO:0007368 determination of left/right symmetry IGI
 biological_processGO:0007507 heart development IMP
 biological_processGO:0014002 astrocyte development IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030325 adrenal gland development IGI
 biological_processGO:0039021 pronephric glomerulus development IGI
 biological_processGO:0039022 pronephric duct development IGI
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060840 artery development IGI
 biological_processGO:0072149 glomerular visceral epithelial cell fate commitment IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
NOTCH2 intracellular domain regulates transcription
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer broken , abnormal
retinal ganglion cell layer separated from retinal neural layer , abnormal
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 ZFA:0000114 heart heart position , abnormal
Show

 ZFA:0000155 somite somite spatial pattern , abnormal
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 ZFA:0000360 heart tube heart tube decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region structure , abnormal
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 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron increased amount , abnormal
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 ZFA:0009280 Muller cell Muller cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000104329 si:ch73-281k2.5 / NOTCH2* / Q04721*  / complex / reaction
 ENSDARG00000079552 maml3 / mastermind-like transcriptional coactivator 3 / Q96JK9*  / reaction / complex
 ENSDARG00000043130 notch2 / Q04721*  / complex / reaction
 ENSDARG00000091563 snw1 / SNW domain containing 1 / Q13573*  / complex
 ENSDARG00000076466 maml1 / mastermind-like transcriptional coactivator 1 / Q6T264* / Q92585* / Mastermind-like protein 1 *  / complex / reaction






 

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