ENSMUSG00000027239


Mus musculus

Features
Gene ID: ENSMUSG00000027239
  
Biological name :Mdk
  
Synonyms : Mdk / Midkine / P12025
  
Possible biological names infered from orthology : P21741
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E1
Gene start: 91929805
Gene end: 91932297
  
Corresponding Affymetrix probe sets: 10485070 (MoGene1.0st)   1416006_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068413
Ensembl peptide - ENSMUSP00000088090
Ensembl peptide - ENSMUSP00000106941
Ensembl peptide - ENSMUSP00000028672
NCBI entrez gene - 17242     See in Manteia.
MGI - MGI:96949
RefSeq - NM_010784
RefSeq - XM_011239335
RefSeq - NM_001012335
RefSeq - NM_001012336
RefSeq - NM_001291481
RefSeq - NM_001291482
RefSeq - NM_001291483
RefSeq Peptide - NP_001278412
RefSeq Peptide - NP_001278410
RefSeq Peptide - NP_001278411
RefSeq Peptide - NP_001012336
RefSeq Peptide - NP_034914
RefSeq Peptide - NP_001012335
swissprot - P12025
Ensembl - ENSMUSG00000027239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mdkaENSDARG00000036036Danio rerio
 mdkbENSDARG00000020708Danio rerio
 MDKENSGALG00000008367Gallus gallus
 MDKENSG00000110492Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptn / P63089 / pleiotrophin / P21246*ENSMUSG0000002983850


Protein motifs (from Interpro)
Interpro ID Name
 IPR000762  Midkine heparin-binding growth factor
 IPR020089  Pleiotrophin/Midkine, N-terminal domain
 IPR020090  Pleiotrophin/Midkine, C-terminal domain
 IPR020091  Pleiotrophin/Midkine disulphide-rich domain superfamily
 IPR020092  Pleiotrophin/Midkine heparin-binding growth factor, conserved site
 IPR037122  Pleiotrophin/Midkine, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007614 short-term memory IMP
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021542 dentate gyrus development IEP
 biological_processGO:0021681 cerebellar granular layer development IMP
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021987 cerebral cortex development IEP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030325 adrenal gland development ISS
 biological_processGO:0030421 defecation IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0050795 regulation of behavior IMP
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:1901215 negative regulation of neuron death IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding ISS


Pathways (from Reactome)
Pathway description
NOTCH2 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Mdktm1Tmu/Mdktm1Tmu,Ptntm1Tmu/Ptntm1Tmu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Mdktm1Tmu/Mdktm1Tmu,Ptntm1Tmu/Ptntm1Tmu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0002704 tubular nephritis "inflammation of the renal tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0003795 abnormal bone structure 
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
Show

Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027239 Mdk / P12025 / Midkine / P21741*  / complex
 ENSMUSG00000027878 Notch2 / Q04721*  / complex / reaction






 

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