ENSMUSG00000029838


Mus musculus

Features
Gene ID: ENSMUSG00000029838
  
Biological name :Ptn
  
Synonyms : P63089 / pleiotrophin / Ptn
  
Possible biological names infered from orthology : P21246
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B1
Gene start: 36714929
Gene end: 36810220
  
Corresponding Affymetrix probe sets: 10543959 (MoGene1.0st)   1416211_a_at (Mouse Genome 430 2.0 Array)   1443173_at (Mouse Genome 430 2.0 Array)   1448254_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099073
Ensembl peptide - ENSMUSP00000144184
NCBI entrez gene - 19242     See in Manteia.
MGI - MGI:97804
RefSeq - XM_006505757
RefSeq - NM_008973
RefSeq Peptide - NP_032999
swissprot - P63089
swissprot - Q3UZI5
Ensembl - ENSMUSG00000029838
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptnENSDARG00000102340Danio rerio
 PTNENSGALG00000040493Gallus gallus
 PTNENSG00000105894Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mdk / P12025 / Midkine / P21741*ENSMUSG0000002723942


Protein motifs (from Interpro)
Interpro ID Name
 IPR000762  Midkine heparin-binding growth factor
 IPR020089  Pleiotrophin/Midkine, N-terminal domain
 IPR020090  Pleiotrophin/Midkine, C-terminal domain
 IPR020091  Pleiotrophin/Midkine disulphide-rich domain superfamily
 IPR020092  Pleiotrophin/Midkine heparin-binding growth factor, conserved site
 IPR037122  Pleiotrophin/Midkine, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IDA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021794 thalamus development IEA
 biological_processGO:0030282 bone mineralization IDA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045446 endothelial cell differentiation IEA
 biological_processGO:0045837 negative regulation of membrane potential IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060221 retinal rod cell differentiation IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072201 negative regulation of mesenchymal cell proliferation IEA
 biological_processGO:1904373 response to kainic acid IEA
 biological_processGO:1904389 rod bipolar cell differentiation IEA
 biological_processGO:1904391 response to ciliary neurotrophic factor IEA
 biological_processGO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering IEA
 biological_processGO:1904397 negative regulation of neuromuscular junction development IEA
 biological_processGO:1990089 response to nerve growth factor IEA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0035373 chondroitin sulfate proteoglycan binding IEA
 molecular_functionGO:0035374 chondroitin sulfate binding IEA
 molecular_functionGO:0038085 vascular endothelial growth factor binding IEA
 molecular_functionGO:0043394 proteoglycan binding IEA
 molecular_functionGO:1904399 heparan sulfate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Mdktm1Tmu/Mdktm1Tmu,Ptntm1Tmu/Ptntm1Tmu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

Allelic Composition: Mdktm1Tmu/Mdktm1Tmu,Ptntm1Tmu/Ptntm1Tmu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

Allelic Composition: Ptntm1Rau/Ptn+
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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