ENSG00000105894


Homo sapiens

Features
Gene ID: ENSG00000105894
  
Biological name :PTN
  
Synonyms : P21246 / pleiotrophin / PTN
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q33
Gene start: 137227341
Gene end: 137343865
  
Corresponding Affymetrix probe sets: 208408_at (Human Genome U133 Plus 2.0 Array)   209465_x_at (Human Genome U133 Plus 2.0 Array)   209466_x_at (Human Genome U133 Plus 2.0 Array)   211737_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341170
Ensembl peptide - ENSP00000376798
NCBI entrez gene - 5764     See in Manteia.
OMIM - 162095
RefSeq - XM_017012473
RefSeq - NM_001321386
RefSeq - NM_001321387
RefSeq - NM_002825
RefSeq Peptide - NP_001308315
RefSeq Peptide - NP_001308316
RefSeq Peptide - NP_002816
swissprot - A0A024R778
swissprot - C9JR52
swissprot - P21246
Ensembl - ENSG00000105894
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptnENSDARG00000102340Danio rerio
 PTNENSGALG00000040493Gallus gallus
 PtnENSMUSG00000029838Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MDK / P21741 / midkineENSG0000011049240


Protein motifs (from Interpro)
Interpro ID Name
 IPR000762  Midkine heparin-binding growth factor
 IPR020089  Pleiotrophin/Midkine, N-terminal domain
 IPR020090  Pleiotrophin/Midkine, C-terminal domain
 IPR020091  Pleiotrophin/Midkine disulphide-rich domain superfamily
 IPR020092  Pleiotrophin/Midkine heparin-binding growth factor, conserved site
 IPR037122  Pleiotrophin/Midkine, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway TAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021794 thalamus development IEA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045446 endothelial cell differentiation IEA
 biological_processGO:0045837 negative regulation of membrane potential IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060221 retinal rod cell differentiation IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072201 negative regulation of mesenchymal cell proliferation IEA
 biological_processGO:1904373 response to kainic acid IEA
 biological_processGO:1904389 rod bipolar cell differentiation IEA
 biological_processGO:1904391 response to ciliary neurotrophic factor IEA
 biological_processGO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering IEA
 biological_processGO:1904397 negative regulation of neuromuscular junction development IEA
 biological_processGO:1990089 response to nerve growth factor IEA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004864 protein phosphatase inhibitor activity TAS
 molecular_functionGO:0005539 glycosaminoglycan binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0035373 chondroitin sulfate proteoglycan binding IEA
 molecular_functionGO:0035374 chondroitin sulfate binding IDA
 molecular_functionGO:0038085 vascular endothelial growth factor binding IEA
 molecular_functionGO:0043394 proteoglycan binding IEA
 molecular_functionGO:1904399 heparan sulfate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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