ENSG00000110492


Homo sapiens

Features
Gene ID: ENSG00000110492
  
Biological name :MDK
  
Synonyms : MDK / midkine / P21741
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 46380756
Gene end: 46383837
  
Corresponding Affymetrix probe sets: 209035_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384034
Ensembl peptide - ENSP00000385451
Ensembl peptide - ENSP00000480875
Ensembl peptide - ENSP00000433240
Ensembl peptide - ENSP00000432649
Ensembl peptide - ENSP00000416241
Ensembl peptide - ENSP00000352852
Ensembl peptide - ENSP00000378932
Ensembl peptide - ENSP00000378933
Ensembl peptide - ENSP00000378936
NCBI entrez gene - 4192     See in Manteia.
OMIM - 162096
RefSeq - XM_017017764
RefSeq - NM_001012333
RefSeq - NM_001012334
RefSeq - NM_001270550
RefSeq - NM_001270551
RefSeq - NM_001270552
RefSeq - NM_002391
RefSeq - XM_011520116
RefSeq Peptide - NP_001012333
RefSeq Peptide - NP_001257479
RefSeq Peptide - NP_001257480
RefSeq Peptide - NP_001257481
RefSeq Peptide - NP_002382
RefSeq Peptide - NP_001012334
swissprot - C9JHA4
swissprot - E9PPJ5
swissprot - E9PLM6
swissprot - P21741
swissprot - A0A087WXB6
Ensembl - ENSG00000110492
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mdkaENSDARG00000036036Danio rerio
 mdkbENSDARG00000020708Danio rerio
 MDKENSGALG00000008367Gallus gallus
 MdkENSMUSG00000027239Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTN / P21246 / pleiotrophinENSG0000010589448


Protein motifs (from Interpro)
Interpro ID Name
 IPR000762  Midkine heparin-binding growth factor
 IPR020089  Pleiotrophin/Midkine, N-terminal domain
 IPR020090  Pleiotrophin/Midkine, C-terminal domain
 IPR020091  Pleiotrophin/Midkine disulphide-rich domain superfamily
 IPR020092  Pleiotrophin/Midkine heparin-binding growth factor, conserved site
 IPR037122  Pleiotrophin/Midkine, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0007614 short-term memory IEA
 biological_processGO:0009611 response to wounding ISS
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021542 dentate gyrus development IEA
 biological_processGO:0021681 cerebellar granular layer development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030154 cell differentiation NAS
 biological_processGO:0030325 adrenal gland development ISS
 biological_processGO:0030421 defecation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0050795 regulation of behavior IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0008083 growth factor activity NAS
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
NOTCH2 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134250 NOTCH2 / Q04721  / complex / reaction
 ENSG00000110492 MDK / P21741 / midkine  / complex






 

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