ENSMUSG00000015468


Mus musculus

Features
Gene ID: ENSMUSG00000015468
  
Biological name :Notch4
  
Synonyms : Notch4
  
Possible biological names infered from orthology : Q99466
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34564268
Gene end: 34588503
  
Corresponding Affymetrix probe sets: 10444352 (MoGene1.0st)   1436901_at (Mouse Genome 430 2.0 Array)   1449146_at (Mouse Genome 430 2.0 Array)   1456263_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015612
Ensembl peptide - ENSMUSP00000133574
Ensembl peptide - ENSMUSP00000133646
Ensembl peptide - ENSMUSP00000134497
NCBI entrez gene - 18132     See in Manteia.
MGI - MGI:107471
RefSeq - XM_006523798
RefSeq - NM_010929
RefSeq Peptide - NP_035059
swissprot - G3UX69
swissprot - A2CG28
swissprot - G3UZH3
Ensembl - ENSMUSG00000015468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOTCH4ENSG00000204301Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*ENSMUSG0000002692342
Notch2 / Q04721*ENSMUSG0000002787841
Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*ENSMUSG0000003814641
Jag2 / Q9QYE5 / Protein jagged-2 / Q9Y219* / jagged 2*ENSMUSG0000000279916
Sned1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSMUSG0000004779316
Jag1 / Q9QXX0 / Protein jagged-1 / P78504* / jagged 1*ENSMUSG0000002727615
Dll1 / Q61483 / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / O00548* / delta like canonical Notch ligand 1*ENSMUSG000000147739
Dll4 / Q9JI71 / Delta-like protein 4 / Q9NR61* / delta like canonical Notch ligand 4*ENSMUSG000000273149


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR008297  Notch
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022355  Neurogenic locus Notch 4
 IPR035993  Notch-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001886 endothelial cell morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045446 endothelial cell differentiation IEA
 biological_processGO:0050793 regulation of developmental process IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
Notch-HLH transcription pathway
NOTCH4 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grm1rcw-3J/Grm1rcw-3J
Genetic Background: C57BL/6J-Grm1rcw-3J/GrsrJ

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Notch1tm1Grid/Notch1+,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Notch3tm1.1(cre/ERT2)Sat/Notch3+
Genetic Background: C57BL/6-Notch3tm1.1(cre/ERT2)Sat

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd

Allelic Composition: Notch4tm1Grid/Notch4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch4tm1(KOMP)Vlcg/Notch4tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Notch4tm1(KOMP)Vlcg/Notch4+
Genetic Background: involves: C57BL/6NTac

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0004784 abnormal anterior cardinal vein morphology "any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd

Allelic Composition: Notch4tm1Grid/Notch4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Notch4tm1(KOMP)Vlcg/Notch4+
Genetic Background: involves: C57BL/6NTac

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
Show

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000015468 Notch4 / Q99466*  / complex






 

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