ENSMUSG00000027276


Mus musculus

Features
Gene ID: ENSMUSG00000027276
  
Biological name :Jag1
  
Synonyms : Jag1 / Protein jagged-1 / Q9QXX0
  
Possible biological names infered from orthology : jagged 1 / P78504
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F3
Gene start: 137081456
Gene end: 137116644
  
Corresponding Affymetrix probe sets: 10488060 (MoGene1.0st)   1421105_at (Mouse Genome 430 2.0 Array)   1421106_at (Mouse Genome 430 2.0 Array)   1434070_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028735
NCBI entrez gene - 16449     See in Manteia.
MGI - MGI:1095416
RefSeq - XM_011239312
RefSeq - NM_013822
RefSeq Peptide - NP_038850
swissprot - Q3UVN4
swissprot - Q9QXX0
Ensembl - ENSMUSG00000027276
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jag1aENSDARG00000030289Danio rerio
 jag1bENSDARG00000013168Danio rerio
 JAG1ENSGALG00000009020Gallus gallus
 JAG1ENSG00000101384Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jag2 / Q9QYE5 / Protein jagged-2 / Q9Y219* / jagged 2*ENSMUSG0000000279953
Notch2 / Q04721*ENSMUSG0000002787829
Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*ENSMUSG0000002692328
Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*ENSMUSG0000003814628
Notch4 / Q99466*ENSMUSG0000001546824
Sned1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSMUSG0000004779322
Dll1 / Q61483 / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / O00548* / delta like canonical Notch ligand 1*ENSMUSG0000001477318
Dll4 / Q9JI71 / Delta-like protein 4 / Q9NR61* / delta like canonical Notch ligand 4*ENSMUSG0000002731417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001007  VWFC domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026219  Jagged/Serrate protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IEA
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002011 morphogenesis of an epithelial sheet IMP
 biological_processGO:0002456 T cell mediated immunity IEA
 biological_processGO:0003184 pulmonary valve morphogenesis IEA
 biological_processGO:0003215 cardiac right ventricle morphogenesis IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032495 response to muramyl dipeptide IDA
 biological_processGO:0035909 aorta morphogenesis IMP
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042491 inner ear auditory receptor cell differentiation IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 biological_processGO:0045602 negative regulation of endothelial cell differentiation IDA
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IDA
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0060411 cardiac septum morphogenesis IMP
 biological_processGO:0061073 ciliary body morphogenesis IMP
 biological_processGO:0061156 pulmonary artery morphogenesis ISS
 biological_processGO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis IMP
 biological_processGO:0061314 Notch signaling involved in heart development IEA
 biological_processGO:0061444 endocardial cushion cell development IMP
 biological_processGO:0072006 nephron development IMP
 biological_processGO:0072015 glomerular visceral epithelial cell development IMP
 biological_processGO:0072017 distal tubule development IEP
 biological_processGO:0072070 loop of Henle development IEP
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0005112 Notch binding ISO
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA


Pathways (from Reactome)
Pathway description
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Jag1tm2.1Grid/Jag1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000036 absent semicircular canals "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Jag1tm2.1Grid/Jag1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000037 abnormal lateral semicircular canal "anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm2.1Grid/Jag1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pitx3tm1.1Jdr/Pitx3tm1.1Jdr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Grid,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Jag1Mhdahtu/Jag1Mhdahtu
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Baxtm1Sjk/Bax+,KitlSl/KitlSl,Tg(Pou5f1-GFP)1Scho/?
Genetic Background: involves: 129X1/SvJ * C3H * CD-1 * FVB

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Kat6atm1Avo/Kat6atm1Avo,Tg(RP23-35B9)33Avo/0
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0000486 abnormal pulmonary trunk morphology "structural anomaly of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0000610 cholestasis "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Kat6atm1Avo/Kat6atm1Avo,Tg(RP23-35B9)33Avo/0
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gfi1Gen/Gfi1+
Genetic Background: C57BL/6J-Gfi1Gen

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0001319 irregularly shaped pupil "shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Six1Cwe/Six1Cwe
Genetic Background: C3HeB/FeJ-Six1Cwe

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Slc12a2tm1Bhk/Slc12a2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Jag1Ozz/Jag1Ozz
Genetic Background: involves: BALB/cOla * C3H

Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Gfi1Gen/Gfi1+
Genetic Background: C57BL/6J-Gfi1Gen

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Jag1Ndr/Jag1Ndr
Genetic Background: involves: C3H

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Ifngtm1Ts/Ifng+,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

Allelic Composition: Jag1tm1Jlew/Jag1tm1Grid,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kat6atm1Avo/Kat6atm1Avo,Tg(RP23-35B9)33Avo/0
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm1Jlew/Jag1tm1Grid,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1Mhdahtu/Jag1Mhdahtu
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

Allelic Composition: Jag1Mhdahtu/Jag1Slalom
Genetic Background: involves: BALB/c * C3H * C3HeB/FeJ

Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Jag1tm2.1Grid/Jag1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg,Akt3tm1Nhy/Akt3tm1Nhy
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/1LacJ

Allelic Composition: Jag1tm1.1Loo/Jag1+,Notch2tm1Grid/Notch2+,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag1Slalom/Jag1Slalom
Genetic Background: involves: BALB/c * C3H

Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0002729 abnormal canal morphology "any anomaly or malformation of the tubular ducts of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Jag1Slalom/Jag1Slalom
Genetic Background: involves: BALB/c * C3H

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Grid,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002858 abnormal posterior semicircular canal "anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

Allelic Composition: Jag1Yo/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Yo

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lcp2tm4Gak/Lcp2tm4Gak,Tg(TcrAND)53Hed/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Jag1tm1Grid/Jag1+,Poglut1Gt(IST10323G11)Tigm/Poglut1+
Genetic Background: B6.Cg-Jag1tm1Grid Poglut1Gt(IST10323G11)Tigm

Allelic Composition: Jag1tm1Grid/Jag1+,Notch2tm3.1Grid/Notch2+
Genetic Background: B6.129S1-Jag1tm1Grid Notch2tm3.1Grid

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm1Grid/Jag1+,Notch2tm1Grid/Notch2+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0003069 abnormal superior semicircular canal "anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

Allelic Composition: Jag1Yo/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Yo

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifng+,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0003151 absent tunnel of Corti "complete absence of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:32991]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Jag1Mhdahtu/Jag1Mhdahtu
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

Allelic Composition: Jag1Mhdahtu/Jag1Slalom
Genetic Background: involves: BALB/c * C3H * C3HeB/FeJ

 MP:0003253 bile duct dilation "abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Jag1tm1.1Loo/Jag1+,Notch2tm1Grid/Notch2+,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003255 bile duct proliferation "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Jag1tm1.1Loo/Jag1+,Notch2tm1Grid/Notch2+,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Jag1Slalom/Jag1Slalom
Genetic Background: involves: BALB/c * C3H

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1Mhdahtu/Jag1Mhdahtu
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003760 short palate "abnormally decreased length to the roof of the oral cavity" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1Mhdahtu/Jag1Mhdahtu
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm2.1Grid/Jag1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifng+,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

Allelic Composition: Jag1Mhdahtu/Jag1+,Six1Cwe/Six1+
Genetic Background: C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004325 absent vestibular hair cells "absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

 MP:0004333 abnormal utricular macula morphology "any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004336 small utricle "reduced size of the larger of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1Slalom/Jag1Slalom
Genetic Background: involves: BALB/c * C3H

Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1Slalom/Jag1Slalom
Genetic Background: involves: BALB/c * C3H

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

Allelic Composition: Jag1Yo/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Yo

 MP:0004403 absent cochlear outer hair cells "absence of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Jlew,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: C57BL/6J

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004406 abnormal cochlear hair cell number "abnormal number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1.1Loo/Jag1+,Notch2tm1Grid/Notch2+,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

 MP:0005083 abnormal biliary tract morphology "anomalous structure or development of the gall bladder or its ducts " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

Allelic Composition: Jag1tm1Grid/Jag1+,Notch2tm3.1Grid/Notch2+
Genetic Background: B6.129S1-Jag1tm1Grid Notch2tm3.1Grid

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0005356 positive geotaxis "mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
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Allelic Composition: Jag1Slalom/Jag1Slalom
Genetic Background: involves: BALB/c * C3H

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifng+,Socs1tm1Wehi/Socs1tm1Wehi
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Spta1sph-3J/Spta1sph-3J
Genetic Background: NOD.Cg-H2b Spta1sph-3J

Allelic Composition: Jag1tm1Jlew/Jag1tm1Grid,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0006048 pulmonary valve insufficiency "the pulmonary valve does not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0006116 aortic valve calcification "pathologic deposition of calcium salts in the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1Mhdahtu/Jag1Slalom
Genetic Background: involves: BALB/c * C3H * C3HeB/FeJ

 MP:0006241 abnormal placement of pupils "abnormal location of the pupil so that it is not in the center of the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0008137 absent podocytes "absence of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Jag1tm1Frad/Jag1tm1Frad,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0008488 abnormal semicircular canal ampulla morphology "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Jag1Slalom/Jag1Slalom
Genetic Background: involves: BALB/c * C3H

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0008727 enlarged right atrium "increased size of the right upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

 MP:0009654 abnormal primary palate development "any anomaly in the formation of the part of the shelf separating the oral and nasal cavities that is formed during early embryonic development from the medial nasal processes which derive from the frontonasal process; these merge with each other and with the bilateral maxillary processes to form the upper lip and the primary palate" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0010451 kidney microaneurysm "focal dilation of arteriocapillary junctions in the kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0010457 pulmonary artery stenosis "constriction or narrowing of the pulmonary artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0010563 increased heart right ventricle size "greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0010714 coloboma of the iris "congenital defect of the iris in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Tagln-cre)1Her/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

Allelic Composition: Jag1Slalom/Jag1Slalom
Genetic Background: involves: BALB/c * C3H

Allelic Composition: Jag1tm2.1Grid/Jag1tm2.1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Jag1Mhdahtu/Jag1Mhdahtu
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

Allelic Composition: Jag1Ndr/Jag1Ndr
Genetic Background: involves: C3H

Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Jag1Yo/Jag1Yo
Genetic Background: C3HeB/FeJ-Jag1Yo

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
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Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Jag1tm1Frad/Jag1tm1Frad,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Wrntm1Led/Wrntm1Led
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * NIH Black Swiss)

 MP:0011648 thick heart valve cusps "an increase in the heart cusp wall thickness" [MGI:csmith]
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia

 MP:0012024 abnormal nephron morphogenesis "any anomaly in the process in which the nephron is generated and organized; the nephron is the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of Henle" [MGI:csmith]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Jag1tm1Frad/Jag1+,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0012085 midface hypoplasia "underdevelopment of the midfacial region comprising the nasal, maxillary, and zygomatic bones, leading to a concave-looking face" [MGI:anna]
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Allelic Composition: Jag1tm2Grid/Jag1tm2Grid,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Jag1Mhdahtu/Jag1Slalom
Genetic Background: involves: BALB/c * C3H * C3HeB/FeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / complex / reaction
 ENSMUSG00000054693 Adam10 / O35598 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672* / ADAM metallopeptidase domain 10*  / reaction
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / reaction / complex






 

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