ENSMUSG00000002799


Mus musculus

Features
Gene ID: ENSMUSG00000002799
  
Biological name :Jag2
  
Synonyms : Jag2 / Protein jagged-2 / Q9QYE5
  
Possible biological names infered from orthology : jagged 2 / Q9Y219
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 112907819
Gene end: 112929776
  
Corresponding Affymetrix probe sets: 10402808 (MoGene1.0st)   1426430_at (Mouse Genome 430 2.0 Array)   1426431_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075224
Ensembl peptide - ENSMUSP00000152342
NCBI entrez gene - 16450     See in Manteia.
MGI - MGI:1098270
RefSeq - XM_011243999
RefSeq - NM_010588
RefSeq - XM_006515486
RefSeq - XM_011243998
RefSeq Peptide - NP_034718
swissprot - A0A1Y7VLS8
swissprot - Q9QYE5
Ensembl - ENSMUSG00000002799
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jag2aENSDARG00000014246Danio rerio
 jag2bENSDARG00000021389Danio rerio
 JAG2ENSGALG00000011696Gallus gallus
 JAG2ENSG00000184916Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jag1 / Q9QXX0 / Protein jagged-1 / P78504* / jagged 1*ENSMUSG0000002727652
Notch2 / Q04721*ENSMUSG0000002787830
Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*ENSMUSG0000002692329
Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*ENSMUSG0000003814629
Notch4 / Q99466*ENSMUSG0000001546825
Sned1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSMUSG0000004779323
Dll1 / Q61483 / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / O00548* / delta like canonical Notch ligand 1*ENSMUSG0000001477319
Dll4 / Q9JI71 / Delta-like protein 4 / Q9NR61* / delta like canonical Notch ligand 4*ENSMUSG0000002731417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001007  VWFC domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026219  Jagged/Serrate protein
 IPR033108  Protein jagged-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001709 cell fate determination NAS
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007605 sensory perception of sound NAS
 biological_processGO:0009912 auditory receptor cell fate commitment IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0042492 gamma-delta T cell differentiation IMP
 biological_processGO:0045061 thymic T cell selection ISS
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 biological_processGO:1990134 epithelial cell apoptotic process involved in palatal shelf morphogenesis IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005112 Notch binding ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Irs1Sml/Irs1Sml
Genetic Background: C3.Cg-Irs1Sml H2b/GrsrJ

 MP:0000430 absent maxillary shelf "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0000431 absent palatine shelf "missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

Allelic Composition: Jag2tm2.2Grid/Jag2tm2.2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pnmttm1(cre)Xbao/Pnmttm1(cre)Xbao
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0001678 thick apical ectodermal ridge "increase in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pnmttm1(cre)Xbao/Pnmttm1(cre)Xbao
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Dll1tm2Gos/Dll1+,Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1+,Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1+,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004396 decreased cochlear inner hair cell number "decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fignfi/Fignfi
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Jag2tm1Grid/Jag2tm1Grid,Lfngtm1Grid/Lfng+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Jag2tm1Grid/Jag2tm1Grid,Lfngtm1Grid/Lfngtm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Jag2tm1Grid/Jag2tm1Grid,Lfngtm1Grid/Lfngtm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Dll1tm2Gos/Dll1+,Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1+,Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0004497 decreased supporting cell number "decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004576 abnormal foot plate morphology "any structural anomaly of the distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. hand, foot, paw)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0008356 abnormal gamma-delta T cell differentiation "atypical production of or inability to produce gamma-delta T cells, and/or accumulation of gamma-delta T cell precursors" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0008919 fused tarsal bones "anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0009884 palatal shelf fusion with tongue or mandible "palatal shelves do not elevate during development and instead fuse with tongue tissues or with the mandible tissues" [PMID:16680722]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Jag2tm2.2Grid/Jag2tm2.2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Jag2tm2.2Grid/Jag2tm2.2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / reaction / complex
 ENSMUSG00000054693 Adam10 / O35598 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672* / ADAM metallopeptidase domain 10*  / reaction
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / complex / reaction






 

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