ENSDARG00000021389


Danio rerio

Features
Gene ID: ENSDARG00000021389
  
Biological name :jag2b
  
Synonyms : jag2b / jagged 2b
  
Possible biological names infered from orthology : JAG2 / jagged 2 / Protein jagged-2 / Q9QYE5 / Q9Y219
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 21391181
Gene end: 21475620
  
Corresponding Affymetrix probe sets: Dr.8287.1.S1_a_at (Zebrafish Array)   NM_131862_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000010799
Ensembl peptide - ENSDARP00000049585
Ensembl peptide - ENSDARP00000150132
NCBI entrez gene - 140422     See in Manteia.
RefSeq - XM_005160485
RefSeq - NM_131862
RefSeq Peptide - NP_571937
swissprot - Q5TZK7
swissprot - Q5TZK8
swissprot - Q0P4F9
ZFIN ID - ZDB-GENE-011128-3
Ensembl - ENSDARG00000021389
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JAG2ENSGALG00000011696Gallus gallus
 JAG2ENSG00000184916Homo sapiens
 Jag2ENSMUSG00000002799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
jag2a / jagged 2a / JAG2* / Q9Y219* / jagged 2*ENSDARG0000001424658
jag1b / jagged 1b / JAG1* / P78504* / Q9QXX0* / jagged 1* / Protein jagged-1 *ENSDARG0000001316852
jag1a / jagged 1a / JAG1* / P78504* / jagged 1*ENSDARG0000003028950
notch2 / Q04721*ENSDARG0000004313027
notch3 / Q9UM47*ENSDARG0000005213927
notch1b / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000005209427
notch1a / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000010355427
sned1 / sushi, nidogen and EGF-like domains 1 / Q8TER0*ENSDARG0000004443319
dla / deltaA / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG0000001079118
dld / deltaD / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG0000002021917
dll4 / delta-like 4 (Drosophila) / Q9JI71* / Q9NR61* / Delta-like protein 4 * / delta like canonical Notch ligand 4*ENSDARG0000007042517
dlb / deltaB / O57409ENSDARG0000000423217
dlc / deltaCENSDARG0000000233617
si:ch73-281k2.5 / NOTCH2* / Q04721*ENSDARG000001043294


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001007  VWFC domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026219  Jagged/Serrate protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021514 ventral spinal cord interneuron differentiation IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0031016 pancreas development IGI
 biological_processGO:0048793 pronephros development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord motor neuron increased amount , abnormal
spinal cord motor neuron mislocalised , abnormal
spinal cord GABAergic neuron increased amount , abnormal
spinal cord GABAergic neuron mislocalised , abnormal
Show

 ZFA:0000123 liver liver canonical Wnt signaling pathway decreased occurrence , abnormal
liver endodermal cell decreased amount , abnormal
Show

 ZFA:0000151 pronephros pronephros multi-ciliated epithelial cell differentiation increased occurrence , abnormal
pronephros cilium increased amount , abnormal
pronephros multi-ciliated epithelial cell increased amount , abnormal
Show

 ZFA:0000563 pectoral fin musculature pectoral fin musculature contractile fiber malformed , abnormal
Show

 ZFA:0001094 whole organism whole organism increased amount , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin actin filament mislocalised , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas canonical Wnt signaling pathway decreased occurrence , abnormal
exocrine pancreas endodermal cell decreased amount , abnormal
Show

 ZFA:0001456 pectoral fin endoskeletal disc pectoral fin endoskeletal disc disorganized , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule has extra parts of type pronephric tubule multi-ciliated epithelial cell, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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