ENSDARG00000103554


Danio rerio

Features
Gene ID: ENSDARG00000103554
  
Biological name :notch1a
  
Synonyms : notch1a
  
Possible biological names infered from orthology : Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / NOTCH1 / P46531 / Q01705
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 4766244
Gene end: 4849056
  
Corresponding Affymetrix probe sets: Dr.11847.1.S1_s_at (Zebrafish Array)   Dr.11847.1.S1_x_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000125740
Ensembl peptide - ENSDARP00000140612
Ensembl peptide - ENSDARP00000137942
NCBI entrez gene - 30718     See in Manteia.
RefSeq - NM_131441
RefSeq Peptide - NP_571516
swissprot - A0A0R4IW83
swissprot - A0A0R4IT11
swissprot - I3IS74
ZFIN ID - ZDB-GENE-990415-173
Ensembl - ENSDARG00000103554
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOTCH1ENSGALG00000002375Gallus gallus
 NOTCH1ENSG00000148400Homo sapiens
 Notch1ENSMUSG00000026923Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
notch1b / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000005209471
notch3 / Q9UM47*ENSDARG0000005213952
notch2 / Q04721*ENSDARG0000004313050
jag2b / jagged 2b / JAG2* / Q9QYE5* / Q9Y219* / jagged 2* / Protein jagged-2 *ENSDARG0000002138914
sned1 / sushi, nidogen and EGF-like domains 1 / Q8TER0*ENSDARG0000004443314
jag1b / jagged 1b / JAG1* / P78504* / Q9QXX0* / jagged 1* / Protein jagged-1 *ENSDARG0000001316814
jag1a / jagged 1a / JAG1* / P78504* / jagged 1*ENSDARG0000003028914
jag2a / jagged 2a / JAG2* / Q9Y219* / jagged 2*ENSDARG0000001424613
dld / deltaD / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG000000202199
dlc / deltaCENSDARG000000023368
dla / deltaA / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG000000107918
dll4 / delta-like 4 (Drosophila) / Q9JI71* / Q9NR61* / Delta-like protein 4 * / delta like canonical Notch ligand 4*ENSDARG000000704257
dlb / deltaB / O57409ENSDARG000000042327
si:ch73-281k2.5 / NOTCH2* / Q04721*ENSDARG000001043296


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR008297  Notch
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022362  Neurogenic locus Notch 1
 IPR024600  Domain of unknown function DUF3454, notch


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0050793 regulation of developmental process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
Activated NOTCH1 Transmits Signal to the Nucleus
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system cellular quality , abnormal
Show

 ZFA:0000029 hindbrain hindbrain epithelium disorganized , abnormal
hindbrain neuron increased amount , abnormal
hindbrain neuroepithelial cell aggregated , abnormal
hindbrain has extra parts of type Mauthner neuron , abnormal
hindbrain has number of Mauthner neuron , ameliorated
Show

 ZFA:0000107 eye eye cell amount , ameliorated
Show

 ZFA:0000132 neural plate neural plate morphology , abnormal
Show

 ZFA:0000152 retina retina cell proliferation process quality , ameliorated
Show

 ZFA:0000155 somite somite morphology , abnormal
somite fused with somite , abnormal
somite quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature quality , abnormal
Show

 ZFA:0000728 somite 2 somite 2 increased length , abnormal
Show

 ZFA:0001094 whole organism whole organism amount , ameliorated
Show

 ZFA:0001115 trunk trunk has fewer parts of type somite , abnormal
Show

 ZFA:0001135 neural tube neural tube morphology , abnormal
Show

 ZFA:0001314 posterior lateral line ganglion posterior lateral line ganglion neuron increased amount , abnormal
Show

 ZFA:0001446 choroid plexus fourth ventricle choroid plexus fourth ventricle shape , abnormal
Show

 ZFA:0001462 somite border somite border morphology , abnormal
Show

 ZFA:0005177 VeLD VeLD decreased amount , abnormal
Show

 ZFA:0005233 CiD CiD increased amount , abnormal
Show

 ZFA:0009063 peripheral neuron peripheral neuron quality , abnormal
Show

 ZFA:0009149 Mauthner neuron Mauthner neuron increased amount , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell amount , ameliorated
Show

 ZFA:0009262 retinal cone cell retinal cone cell amount , ameliorated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr