ENSDARG00000020219


Danio rerio

Features
Gene ID: ENSDARG00000020219
  
Biological name :dld
  
Synonyms : deltaD / dld
  
Possible biological names infered from orthology : delta like canonical Notch ligand 1 / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / DLL1 / O00548 / Q61483
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 6075572
Gene end: 6081803
  
Corresponding Affymetrix probe sets: Dr.20958.1.S1_at (Zebrafish Array)   NM_130955_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000089996
NCBI entrez gene - 30138     See in Manteia.
RefSeq - NM_130955
RefSeq Peptide - NP_571030
swissprot - F1QFH0
ZFIN ID - ZDB-GENE-990415-47
Ensembl - ENSDARG00000020219
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DLL1ENSGALG00000011182Gallus gallus
 DLL1ENSG00000198719Homo sapiens
 Dll1ENSMUSG00000014773Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dla / deltaA / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG0000001079173
dll4 / delta-like 4 (Drosophila) / Q9JI71* / Q9NR61* / Delta-like protein 4 * / delta like canonical Notch ligand 4*ENSDARG0000007042547
dlc / deltaCENSDARG0000000233644
dlb / deltaB / O57409ENSDARG0000000423243
jag1b / jagged 1b / JAG1* / P78504* / Q9QXX0* / jagged 1* / Protein jagged-1 *ENSDARG0000001316831
jag1a / jagged 1a / JAG1* / P78504* / jagged 1*ENSDARG0000003028931
notch1b / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000005209430
jag2b / jagged 2b / JAG2* / Q9QYE5* / Q9Y219* / jagged 2* / Protein jagged-2 *ENSDARG0000002138930
notch1a / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000010355429
jag2a / jagged 2a / JAG2* / Q9Y219* / jagged 2*ENSDARG0000001424629
notch3 / Q9UM47*ENSDARG0000005213929
notch2 / Q04721*ENSDARG0000004313027
sned1 / sushi, nidogen and EGF-like domains 1 / Q8TER0*ENSDARG0000004443319
si:ch73-281k2.5 / NOTCH2* / Q04721*ENSDARG000001043296


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle motile cilium decreased length , abnormal
Show

 ZFA:0000073 somite 5 somite 5 increased length , abnormal
Show

 ZFA:0000101 diencephalon diencephalon morphology , abnormal
Show

 ZFA:0000112 gut gut mislocalised , abnormal
gut quality , abnormal
gut morphology , abnormal
Show

 ZFA:0000123 liver liver mislocalised , abnormal
Show

 ZFA:0000128 midbrain midbrain morphology , abnormal
Show

 ZFA:0000135 notochord notochord undulate , abnormal
Show

 ZFA:0000155 somite somite morphology , abnormal
somite quality , abnormal
Show

 ZFA:0000633 caudal tuberculum caudal tuberculum morphology , abnormal
Show

 ZFA:0000728 somite 2 somite 2 increased length , abnormal
Show

 ZFA:0000732 somite 3 somite 3 increased length , abnormal
Show

 ZFA:0000857 somite 4 somite 4 increased length , abnormal
Show

 ZFA:0001056 myotome myotome actin filament increased length , abnormal
myotome myosin filament disorganized , abnormal
Show

 ZFA:0001078 thymus thymus T cell absent , abnormal
Show

 ZFA:0001314 posterior lateral line ganglion posterior lateral line ganglion neuron increased amount , abnormal
posterior lateral line ganglion neuron decreased amount , abnormal
Show

 ZFA:0001443 choroid plexus choroid plexus increased distribution , abnormal
Show

 ZFA:0001446 choroid plexus fourth ventricle choroid plexus fourth ventricle increased size , abnormal
Show

 ZFA:0001462 somite border somite border deformed , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta decreased amount , abnormal
ventral wall of dorsal aorta hematopoietic stem cell decreased amount , abnormal
ventral wall of dorsal aorta hematopoietic stem cell decreased amount , exacerbated
Show

 ZFA:0005177 VeLD VeLD increased amount , abnormal
Show

 ZFA:0005233 CiD CiD increased amount , abnormal
Show

 ZFA:0005341 medial longitudinal catecholaminergic tract medial longitudinal catecholaminergic tract increased size , abnormal
Show

 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
hematopoietic stem cell absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr