ENSDARG00000052094


Danio rerio

Features
Gene ID: ENSDARG00000052094
  
Biological name :notch1b
  
Synonyms : notch1b
  
Possible biological names infered from orthology : Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / NOTCH1 / P46531 / Q01705
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 65679595
Gene end: 65782785
  
Corresponding Affymetrix probe sets: Dr.11846.1.S1_at (Zebrafish Array)   NM_131302_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000050854
Ensembl peptide - ENSDARP00000105460
Ensembl peptide - ENSDARP00000151240
NCBI entrez gene - 794892     See in Manteia.
RefSeq - NM_131302
RefSeq Peptide - NP_571377
swissprot - F1QCA7
swissprot - A5WUN6
swissprot - O93616
ZFIN ID - ZDB-GENE-990415-183
Ensembl - ENSDARG00000052094
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOTCH1ENSGALG00000002375Gallus gallus
 NOTCH1ENSG00000148400Homo sapiens
 Notch1ENSMUSG00000026923Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
notch1a / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000010355470
notch3 / Q9UM47*ENSDARG0000005213951
notch2 / Q04721*ENSDARG0000004313049
jag2b / jagged 2b / JAG2* / Q9QYE5* / Q9Y219* / jagged 2* / Protein jagged-2 *ENSDARG0000002138914
sned1 / sushi, nidogen and EGF-like domains 1 / Q8TER0*ENSDARG0000004443314
jag1b / jagged 1b / JAG1* / P78504* / Q9QXX0* / jagged 1* / Protein jagged-1 *ENSDARG0000001316814
jag1a / jagged 1a / JAG1* / P78504* / jagged 1*ENSDARG0000003028914
jag2a / jagged 2a / JAG2* / Q9Y219* / jagged 2*ENSDARG0000001424613
dld / deltaD / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG000000202199
dla / deltaA / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG000000107918
dlc / deltaCENSDARG000000023368
dlb / deltaB / O57409ENSDARG000000042327
dll4 / delta-like 4 (Drosophila) / Q9JI71* / Q9NR61* / Delta-like protein 4 * / delta like canonical Notch ligand 4*ENSDARG000000704257
si:ch73-281k2.5 / NOTCH2* / Q04721*ENSDARG000001043296


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR008297  Notch
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022362  Neurogenic locus Notch 1
 IPR024600  Domain of unknown function DUF3454, notch


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021514 ventral spinal cord interneuron differentiation IGI
 biological_processGO:0021654 rhombomere boundary formation IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0035907 dorsal aorta development IGI
 biological_processGO:0048936 peripheral nervous system neuron axonogenesis IGI
 biological_processGO:0050793 regulation of developmental process IEA
 biological_processGO:0060840 artery development IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IMP
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
Activated NOTCH1 Transmits Signal to the Nucleus
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta anatomical region absent , abnormal
dorsal aorta vascular associated smooth muscle cell absent , abnormal
dorsal aorta vascular associated smooth muscle cell decreased amount , abnormal
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 ZFA:0000114 heart heart absent , abnormal
heart decreased amount , abnormal
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 ZFA:0000505 dorsal telencephalon dorsal telencephalon ventricular zone has extra parts of type neuron , abnormal
dorsal telencephalon radial glial cell cellular potency , abnormal
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 ZFA:0001061 intersegmental artery intersegmental artery decreased amount , abnormal
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 ZFA:0001270 blastema blastema cell proliferation decreased process quality , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
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 ZFA:0001446 choroid plexus fourth ventricle choroid plexus fourth ventricle increased size , abnormal
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 ZFA:0005059 trabecular layer trabecular layer absent , abnormal
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 ZFA:0005073 atrioventricular ring atrioventricular ring amount , ameliorated
atrioventricular ring position , ameliorated
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 ZFA:0005110 thoracic duct thoracic duct absent , abnormal
thoracic duct wholeness , abnormal
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 ZFA:0005177 VeLD VeLD decreased amount , abnormal
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 ZFA:0005233 CiD CiD increased amount , abnormal
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 ZFA:0009063 peripheral neuron peripheral neuron decreased length , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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