ENSDARG00000052139


Danio rerio

Features
Gene ID: ENSDARG00000052139
  
Biological name :notch3
  
Synonyms : notch3
  
Possible biological names infered from orthology : Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q61982 / Q9UM47
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 53526025
Gene end: 53559581
  
Corresponding Affymetrix probe sets: Dr.1327.1.S1_at (Zebrafish Array)   Dr.25314.1.A1_at (Zebrafish Array)   NM_131549_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000068420
Ensembl peptide - ENSDARP00000149426
Ensembl peptide - ENSDARP00000153292
NCBI entrez gene - 58066     See in Manteia.
RefSeq - NM_131549
RefSeq Peptide - NP_571624
swissprot - F1QZF2
ZFIN ID - ZDB-GENE-000329-5
Ensembl - ENSDARG00000052139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOTCH3ENSG00000074181Homo sapiens
 Notch3ENSMUSG00000038146Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
notch1a / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000010355451
notch1b / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000005209451
notch2 / Q04721*ENSDARG0000004313050
jag2b / jagged 2b / JAG2* / Q9QYE5* / Q9Y219* / jagged 2* / Protein jagged-2 *ENSDARG0000002138914
sned1 / sushi, nidogen and EGF-like domains 1 / Q8TER0*ENSDARG0000004443314
jag1b / jagged 1b / JAG1* / P78504* / Q9QXX0* / jagged 1* / Protein jagged-1 *ENSDARG0000001316814
jag2a / jagged 2a / JAG2* / Q9Y219* / jagged 2*ENSDARG0000001424614
jag1a / jagged 1a / JAG1* / P78504* / jagged 1*ENSDARG0000003028914
dla / deltaA / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG000000107918
dlc / deltaCENSDARG000000023368
dld / deltaD / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG000000202198
dll4 / delta-like 4 (Drosophila) / Q9JI71* / Q9NR61* / Delta-like protein 4 * / delta like canonical Notch ligand 4*ENSDARG000000704257
dlb / deltaB / O57409ENSDARG000000042327
si:ch73-281k2.5 / NOTCH2* / Q04721*ENSDARG000001043296


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR008297  Notch
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022331  Neurogenic locus Notch 3
 IPR024600  Domain of unknown function DUF3454, notch


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001840 neural plate development IGI
 biological_processGO:0001889 liver development IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0021514 ventral spinal cord interneuron differentiation IGI
 biological_processGO:0021654 rhombomere boundary formation IGI
 biological_processGO:0021865 obsolete symmetric radial glial cell division in forebrain IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEP
 biological_processGO:0035633 maintenance of permeability of blood-brain barrier IMP
 biological_processGO:0035907 dorsal aorta development IMP
 biological_processGO:0043114 regulation of vascular permeability IMP
 biological_processGO:0048259 regulation of receptor-mediated endocytosis IGI
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0048936 peripheral nervous system neuron axonogenesis IGI
 biological_processGO:0050768 negative regulation of neurogenesis IGI
 biological_processGO:0050793 regulation of developmental process IEA
 biological_processGO:0050880 regulation of blood vessel size IMP
 biological_processGO:0060842 arterial endothelial cell differentiation IMP
 biological_processGO:0061056 sclerotome development IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IMP
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
NOTCH3 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation caudal fin , abnormal
blood accumulation head , abnormal
blood accumulation pectoral fin , abnormal
blood accumulation pelvic fin , abnormal
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 ZFA:0000029 hindbrain hindbrain cell death increased rate , abnormal
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 ZFA:0000079 telencephalon telencephalon blood vessel prominent , abnormal
telencephalon blood vessel dilated , abnormal
telencephalon blood vessel increased diameter , abnormal
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 ZFA:0000151 pronephros pronephros cellular quality , abnormal
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 ZFA:0000445 optic tectum optic tectum capillary decreased variability of size , abnormal
optic tectum blood vessel decreased variability of size , abnormal
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 ZFA:0000505 dorsal telencephalon dorsal telencephalon radial glial cell proliferative , abnormal
dorsal telencephalon ventricular zone has extra parts of type radial glial cell , abnormal
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 ZFA:0000737 cranium cranium deformed , abnormal
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 ZFA:0001094 whole organism whole organism curved , abnormal
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 ZFA:0001261 ventricular system ventricular system blood mislocalised , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature hemorrhagic , abnormal
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 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 increased distribution , abnormal
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 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 increased distribution , abnormal
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 ZFA:0005297 cranial blood vessel cranial blood vessel pericyte decreased amount , abnormal
cranial blood vessel decreased branchiness , abnormal
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 ZFA:0005304 caudal fin blood vessel caudal fin blood vessel broken , abnormal
caudal fin blood vessel increased diameter , abnormal
caudal fin blood vessel hemorrhagic , abnormal
caudal fin blood vessel displaced , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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