ENSDARG00000013168


Danio rerio

Features
Gene ID: ENSDARG00000013168
  
Biological name :jag1b
  
Synonyms : jag1b / jagged 1b
  
Possible biological names infered from orthology : JAG1 / jagged 1 / P78504 / Protein jagged-1 / Q9QXX0
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 35339182
Gene end: 35390095
  
Corresponding Affymetrix probe sets: Dr.12589.1.S1_at (Zebrafish Array)   NM_131863_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000008197
NCBI entrez gene - 140423     See in Manteia.
RefSeq - NM_131863
RefSeq Peptide - NP_571938
swissprot - F1R986
ZFIN ID - ZDB-GENE-011128-4
Ensembl - ENSDARG00000013168
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JAG1ENSGALG00000009020Gallus gallus
 JAG1ENSG00000101384Homo sapiens
 Jag1ENSMUSG00000027276Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
jag1a / jagged 1a / JAG1* / P78504* / jagged 1*ENSDARG0000003028971
jag2b / jagged 2b / JAG2* / Q9QYE5* / Q9Y219* / jagged 2* / Protein jagged-2 *ENSDARG0000002138953
jag2a / jagged 2a / JAG2* / Q9Y219* / jagged 2*ENSDARG0000001424649
notch3 / Q9UM47*ENSDARG0000005213928
notch1a / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000010355428
notch2 / Q04721*ENSDARG0000004313028
notch1b / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000005209428
sned1 / sushi, nidogen and EGF-like domains 1 / Q8TER0*ENSDARG0000004443319
dla / deltaA / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG0000001079118
dld / deltaD / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG0000002021918
dlc / deltaCENSDARG0000000233617
dll4 / delta-like 4 (Drosophila) / Q9JI71* / Q9NR61* / Delta-like protein 4 * / delta like canonical Notch ligand 4*ENSDARG0000007042517
dlb / deltaB / O57409ENSDARG0000000423216
si:ch73-281k2.5 / NOTCH2* / Q04721*ENSDARG000001043295


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001007  VWFC domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026219  Jagged/Serrate protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle anterior-posterior axis decreased length , abnormal
otic vesicle posterior crista apoptotic , abnormal
otic vesicle posterior crista absent , abnormal
otic vesicle anterior crista absent , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000123 liver liver canonical Wnt signaling pathway decreased occurrence , abnormal
liver endodermal cell absent , abnormal
liver absent , abnormal
liver lacks all parts of type intrahepatic bile duct , abnormal
Show

 ZFA:0000135 notochord notochord morphology , abnormal
Show

 ZFA:0000151 pronephros pronephros edematous , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased length , abnormal
Show

 ZFA:0000220 lateral semicircular canal lateral semicircular canal decreased size , abnormal
Show

 ZFA:0000250 opercle opercle curved , abnormal
opercle decreased width , abnormal
Show

 ZFA:0000566 posterior crista posterior crista hair cell absent , abnormal
Show

 ZFA:0000619 anterior crista anterior crista hair cell absent , abnormal
Show

 ZFA:0000672 hyomandibula hyomandibula morphology , abnormal
hyomandibula decreased size , abnormal
Show

 ZFA:0000692 symplectic symplectic decreased size , abnormal
Show

 ZFA:0001058 caudal fin caudal fin truncated , abnormal
caudal fin kinked , abnormal
Show

 ZFA:0001072 thyroid follicle thyroid follicle decreased amount , abnormal
Show

 ZFA:0001081 thyroid primordium thyroid primordium malformed , abnormal
thyroid primordium aplastic/hypoplastic , abnormal
thyroid primordium decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism anterior-posterior axis decreased length , abnormal
Show

 ZFA:0001104 pharyngeal endoderm pharyngeal endoderm decreased amount , abnormal
Show

 ZFA:0001158 endocrine system endocrine system has fewer parts of type thyroid follicle , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Meckels cartilage morphology , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas canonical Wnt signaling pathway decreased occurrence , abnormal
exocrine pancreas endodermal cell absent , abnormal
exocrine pancreas lacks all parts of type intrapancreatic duct , abnormal
exocrine pancreas decreased distribution , abnormal
exocrine pancreas decreased amount , abnormal
exocrine pancreas absent , abnormal
Show

 ZFA:0001260 endocrine pancreas endocrine pancreas has fewer parts of type endocrine cell , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch mislocalised , abnormal
pharyngeal arch increased distribution , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased size , abnormal
palatoquadrate cartilage truncated , abnormal
palatoquadrate cartilage morphology , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage malformed , abnormal
hyosymplectic cartilage deformed , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage ventral region morphology , abnormal
pharyngeal arch cartilage ventral region amount , ameliorated
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 ventral region morphology , abnormal
pharyngeal arch 2 ventral region size , ameliorated
pharyngeal arch 2 increased distribution , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 ventral region morphology , abnormal
pharyngeal arch 1 increased distribution , abnormal
Show

 ZFA:0001715 otic vesicle protrusion otic vesicle protrusion shape , abnormal
otic vesicle protrusion malformed , abnormal
Show

 ZFA:0007054 pillar of the anterior semicircular canal pillar of the anterior semicircular canal increased thickness , abnormal
Show

 ZFA:0007055 pillar of the lateral semicircular canal pillar of the lateral semicircular canal increased thickness , abnormal
Show

 ZFA:0009218 thyroid stimulating hormone secreting cell thyroid stimulating hormone secreting cell increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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