ENSDARG00000010791


Danio rerio

Features
Gene ID: ENSDARG00000010791
  
Biological name :dla
  
Synonyms : deltaA / dla
  
Possible biological names infered from orthology : delta like canonical Notch ligand 1 / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / DLL1 / O00548 / Q61483
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 54013457
Gene end: 54026352
  
Corresponding Affymetrix probe sets: Dr.10492.1.S1_at (Zebrafish Array)   NM_130954_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000110944
Ensembl peptide - ENSDARP00000013374
NCBI entrez gene - 30131     See in Manteia.
RefSeq - NM_130954
RefSeq Peptide - NP_571029
swissprot - F1R7K3
swissprot - F1QWN4
ZFIN ID - ZDB-GENE-980526-29
Ensembl - ENSDARG00000010791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DLL1ENSGALG00000011182Gallus gallus
 DLL1ENSG00000198719Homo sapiens
 Dll1ENSMUSG00000014773Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dld / deltaD / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG0000002021968
dll4 / delta-like 4 (Drosophila) / Q9JI71* / Q9NR61* / Delta-like protein 4 * / delta like canonical Notch ligand 4*ENSDARG0000007042542
dlc / deltaCENSDARG0000000233641
dlb / deltaB / O57409ENSDARG0000000423240
jag1a / jagged 1a / JAG1* / P78504* / jagged 1*ENSDARG0000003028929
jag2b / jagged 2b / JAG2* / Q9QYE5* / Q9Y219* / jagged 2* / Protein jagged-2 *ENSDARG0000002138929
jag1b / jagged 1b / JAG1* / P78504* / Q9QXX0* / jagged 1* / Protein jagged-1 *ENSDARG0000001316828
jag2a / jagged 2a / JAG2* / Q9Y219* / jagged 2*ENSDARG0000001424628
notch1b / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000005209426
notch1a / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000010355426
notch3 / Q9UM47*ENSDARG0000005213925
notch2 / Q04721*ENSDARG0000004313024
sned1 / sushi, nidogen and EGF-like domains 1 / Q8TER0*ENSDARG0000004443318
si:ch73-281k2.5 / NOTCH2* / Q04721*ENSDARG000001043295


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000022 floor plate floor plate quality , abnormal
Show

 ZFA:0000029 hindbrain hindbrain disorganized , abnormal
Show

 ZFA:0000030 macula utricle macula utricle has extra parts of type hair cell , abnormal
macula utricle has extra parts of type tether cell , abnormal
macula utricle has extra parts of type immature hair cell anterior macula , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle has extra parts of type hair cell , abnormal
otic vesicle has extra parts of type tether cell , abnormal
otic vesicle lacks parts or has fewer parts of type auditory epithelial support cell , abnormal
Show

 ZFA:0000075 spinal cord spinal cord glial cell decreased amount , abnormal
Show

 ZFA:0000101 diencephalon diencephalon morphology , abnormal
Show

 ZFA:0000135 notochord notochord quality , abnormal
Show

 ZFA:0000386 macula macula has extra parts of type hair cell , abnormal
Show

 ZFA:0000566 posterior crista posterior crista has extra parts of type hair cell , abnormal
Show

 ZFA:0000633 caudal tuberculum caudal tuberculum morphology , abnormal
Show

 ZFA:0001064 rhombomere rhombomere morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism bent , abnormal
Show

 ZFA:0001115 trunk trunk curved dorsal , abnormal
Show

 ZFA:0001314 posterior lateral line ganglion posterior lateral line ganglion neuron increased amount , abnormal
posterior lateral line ganglion neuron decreased amount , abnormal
Show

 ZFA:0001617 otolith otolith malformed , abnormal
Show

 ZFA:0005177 VeLD VeLD increased amount , abnormal
Show

 ZFA:0005233 CiD CiD increased amount , abnormal
Show

 ZFA:0009149 Mauthner neuron Mauthner neuron increased amount , abnormal
Mauthner neuron axon fasciculation , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron increased amount , abnormal
Show

 ZFA:0009247 secondary motor neuron secondary motor neuron irregular spatial pattern , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr